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MDS1 and EVI1 Complex Locus (MECOM) ELISA Kits

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. Additionally we are shipping MDS1 and EVI1 Complex Locus Antibodies (114) and MDS1 and EVI1 Complex Locus Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Anti-Rat MECOM MECOM 294924  
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More ELISA Kits for MDS1 and EVI1 Complex Locus Interaction Partners

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 ELISA Kits) signaling

  2. Prdm3 and prdm16 (show PRDM16 ELISA Kits) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. MECOM deletion is associated with congenital thrombocytopenia.

  2. ETV6 (show ETV6 ELISA Kits)/RUNX1 (show RUNX1 ELISA Kits) transcript is a target of RNA-binding protein (show PTBP1 ELISA Kits) IGF2BP1 (show IGF2BP1 ELISA Kits) in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia.

  3. Runx1 (show RUNX1 ELISA Kits) haploinsufficiency appears to predispose FPD patients to MM by expanding the pool of stem/progenitor cells and blocking myeloid differentiation in response to G-CSF (show CSF3 ELISA Kits).

  4. RUNX1 (show RUNX1 ELISA Kits) haploinsufficiency collaborates with genetic alterations conferring clonal advantage such as TET2 (show TET2 ELISA Kits) mutation or trisomy 21 to establish pre-leukemic state.

  5. involvement of MECOM in patients with acute myeloid leukemia (show BCL11A ELISA Kits) and myelodysplastic syndrome with various 3q abnormalities

  6. The study shows a low representation of ETV6 (show ETV6 ELISA Kits)-RUNX1 (show RUNX1 ELISA Kits) fusion oncogenes among pediatric acute lymphoblastic leukemia patients from King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.

  7. Germline RUNX1 (show RUNX1 ELISA Kits) mutations are associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia (show BCL11A ELISA Kits).

  8. Two novel translocations leading to the inactivation of RUNX1 (show RUNX1 ELISA Kits) and its partners SIN3A and TCF12 (show TCF12 ELISA Kits) in myeloid leukemia (show BCL11A ELISA Kits).

  9. RUNX1-Evi-1 (show RUNX1 ELISA Kits) may promote proliferation and apoptosis resistance of primitive hematopoietic cell, and inhibit the differentiation of myeloid cells with the synergy of different pathways and factors.

  10. Thus, an NGF (show NGFB ELISA Kits)/TrkA (show NTRK1 ELISA Kits)-MAPK (show MAPK1 ELISA Kits)-CBFbeta (show CBFB ELISA Kits) pathway converges with Islet1 (show ISL1 ELISA Kits)-Runx1 (show RUNX1 ELISA Kits) signaling to promote Runx1 (show RUNX1 ELISA Kits)/CBFbeta (show CBFB ELISA Kits) holocomplex formation and nonpeptidergic nociceptor maturation.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 ELISA Kits), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 ELISA Kits) levels.

  2. Survivin (show BIRC5 ELISA Kits) partially regulates HSC (show FUT1 ELISA Kits) function by modulating the Evi-1 transcription factor and its downstream targets

  3. Thrombopoietin (show THPO ELISA Kits)/MPL (show MPL ELISA Kits) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  4. Prdm16 (show PRDM16 ELISA Kits) and Prdm3 control postnatal BAT (show BAAT ELISA Kits) identity and function.

  5. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  6. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL ELISA Kits)) fusion protein (MFP) leukemia

  7. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (show CEBPB ELISA Kits), liver inhibitory protein (LIP), induced acute myeloid leukemia (show BCL11A ELISA Kits) with short latencies in a mouse bone marow transplantation model.

  8. Transient Evi1 transfection inhibited TGF-beta (show TGFB1 ELISA Kits)-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta (show TGFB1 ELISA Kits) in MC-26 (show Glycam1 ELISA Kits) mouse colon cancer cells.

  9. Evi1 is a key regulator of adipogenic competency

  10. Data identify Prdm3 and Prdm16 (show PRDM16 ELISA Kits) as H3K9me1 methyltransferases and expose a functional framework in which anchoring to the nuclear periphery helps maintain the integrity of mammalian heterochromatin.

MDS1 and EVI1 Complex Locus (MECOM) Antigen Profile

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom) antibody
  • MDS1 and EVI1 complex locus (MECOM) antibody
  • MDS1 and EVI1 complex locus (LOC100343228) antibody
  • MDS1 and EVI1 complex locus (Mecom) antibody
  • runt-related transcription factor 1 (RUNX1) antibody
  • AML1 antibody
  • AML1-EVI-1 antibody
  • AMLCR1 antibody
  • CBFA2 antibody
  • D630039M04Rik antibody
  • EVI-1 antibody
  • Evi1 antibody
  • im:7140716 antibody
  • Jbo antibody
  • Mds antibody
  • Mds1 antibody
  • Mds1-Evi1 antibody
  • PEBP2aB antibody
  • Prdm3 antibody
  • Znfpr1b1 antibody

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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