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MDS1 and EVI1 Complex Locus (MECOM) ELISA Kits

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. Additionally we are shipping MDS1 and EVI1 Complex Locus Antibodies (118) and MDS1 and EVI1 Complex Locus Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Anti-Rat MECOM MECOM 294924  
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More ELISA Kits for MDS1 and EVI1 Complex Locus Interaction Partners

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 ELISA Kits) signaling

  2. Prdm3 and prdm16 (show PRDM16 ELISA Kits) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (show NR4A2 ELISA Kits))early growth response (EGR)2 (show EGR2 ELISA Kits) and NR4A2EGR3. Therefore, RUNX1 (show RUNX1 ELISA Kits), NR4A2 (show NR4A2 ELISA Kits), EGR2 (show EGR2 ELISA Kits), EGR3 (show EGR3 ELISA Kits) and ID4 (show ID4 ELISA Kits) may be key genes associated with the pathogenesis of DS.

  2. Study shows that AML1 gene overexpression characterizes a broader range of leukemic subtypes than previously thought, including various maturation stages of B-cell acute lymphoblastic leukemia and cytogenetic types additional to those involving the AML1 gene.

  3. MECOM gene harbors both somatic frameshift mutations.

  4. the effects of various aberrations in ETV6 (show ETV6 ELISA Kits) and RUNX1 (show RUNX1 ELISA Kits) gene copy number on disease prognosis were evaluated in 21 pediatric patients diagnosed with B-cell ALL with/without t(12;21).

  5. The RUNX1 (show RUNX1 ELISA Kits) fusion transcript encodes a truncated protein containing the Runt (show RUNX1 ELISA Kits) homology domain responsible for both heterodimerization with CBFB (show CBFB ELISA Kits) and DNA binding, but lacking the proline-, serine-, and threonine-rich (PST (show SULT1A1 ELISA Kits)) region which is the transcription activation domain at the C terminal end

  6. novel RUNX1 (show RUNX1 ELISA Kits) isoforms contribute in controlling CD56 (show NCAM1 ELISA Kits) expression in acute myeloid leukemia (show BCL11A ELISA Kits) cells.

  7. this paper shows that RUNX1 (show RUNX1 ELISA Kits) is associated with the pathogenesis of immune thrombocytopenia possibly through regulation of Th17 cell differentiation

  8. We show that RUNX1 (show RUNX1 ELISA Kits) P1 expression is associated with colon cancer free survival suggesting a role for RUNX1 (show RUNX1 ELISA Kits) in aspirin's protective effect in colon cancer. Our studies reveal an effect of aspirin on RUNX1 (show RUNX1 ELISA Kits) and gene expression that may additionally explain aspirin's effects in cardiovascular disease and cancer.

  9. we identified rs2249650 and rs2268276 as new AML (show RUNX1 ELISA Kits) susceptibility-associated SNPs. Genome editing at rs2249650 and rs2268276 may be performed in future to uncover the effect of this potential RUNX1 (show RUNX1 ELISA Kits) enhancer region.

  10. RUNX1 (show RUNX1 ELISA Kits) and FKBP7 (show FKBP7 ELISA Kits), involved in erythropoesis and muscle protein synthesis, respectively, are related to change in cardiorespiratory fitness in response to exercise.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (show CEBPA ELISA Kits) from EVI1-induced suppression.

  2. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 ELISA Kits), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 ELISA Kits) levels.

  3. Survivin (show BIRC5 ELISA Kits) partially regulates HSC (show FUT1 ELISA Kits) function by modulating the Evi-1 transcription factor and its downstream targets

  4. Thrombopoietin (show THPO ELISA Kits)/MPL (show MPL ELISA Kits) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  5. Prdm16 (show PRDM16 ELISA Kits) and Prdm3 control postnatal BAT (show BAAT ELISA Kits) identity and function.

  6. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  7. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL ELISA Kits)) fusion protein (MFP) leukemia

  8. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (show CEBPB ELISA Kits), liver inhibitory protein (LIP), induced acute myeloid leukemia (show BCL11A ELISA Kits) with short latencies in a mouse bone marow transplantation model.

  9. Transient Evi1 transfection inhibited TGF-beta (show TGFB1 ELISA Kits)-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta (show TGFB1 ELISA Kits) in MC-26 (show Glycam1 ELISA Kits) mouse colon cancer cells.

  10. Evi1 is a key regulator of adipogenic competency

MDS1 and EVI1 Complex Locus (MECOM) Antigen Profile

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom) antibody
  • MDS1 and EVI1 complex locus (MECOM) antibody
  • MDS1 and EVI1 complex locus (LOC100343228) antibody
  • MDS1 and EVI1 complex locus (Mecom) antibody
  • runt-related transcription factor 1 (RUNX1) antibody
  • AML1 antibody
  • AML1-EVI-1 antibody
  • AMLCR1 antibody
  • CBFA2 antibody
  • D630039M04Rik antibody
  • EVI-1 antibody
  • Evi1 antibody
  • im:7140716 antibody
  • Jbo antibody
  • Mds antibody
  • Mds1 antibody
  • Mds1-Evi1 antibody
  • PEBP2aB antibody
  • Prdm3 antibody
  • Znfpr1b1 antibody

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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