MDS1 and EVI1 Complex Locus (MECOM) ELISA Kits

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. Additionally we are shipping MDS1 and EVI1 Complex Locus Antibodies (118) and MDS1 and EVI1 Complex Locus Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Anti-Rat MECOM MECOM 294924  
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Top MDS1 and EVI1 Complex Locus ELISA Kits at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 15 to 18 Days
$875.60
Details
Mouse
96 Tests Log in to see 15 to 18 Days
$875.60
Details

More ELISA Kits for MDS1 and EVI1 Complex Locus Interaction Partners

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 ELISA Kits) signaling

  2. Prdm3 and prdm16 (show PRDM16 ELISA Kits) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Heterozygous germ line mutations in the RUNX1 (show RUNX1 ELISA Kits) gene are responsible genetic events for FPD/AML (show RUNX1 ELISA Kits).

  2. Data suggest that RUNX1 (show RUNX1 ELISA Kits) pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1 (show RUNX1 ELISA Kits), either mutations in RUNX1 (show RUNX1 ELISA Kits) gene or variations in expression of RUNX1 (show RUNX1 ELISA Kits), appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  3. The E3 ubiquitin ligase STUB1 (show STUB1 ELISA Kits) is a negative regulator of both RUNX1 (show RUNX1 ELISA Kits) and RUNX1 (show RUNX1 ELISA Kits)-RUNX1T1 (show RUNX1T1 ELISA Kits). Activation of STUB1 (show STUB1 ELISA Kits) could be a promising therapeutic strategy for RUNX1 (show RUNX1 ELISA Kits)-RUNX1T1 (show RUNX1T1 ELISA Kits) leukemia.

  4. The clinical significance of ETV6 (show ETV6 ELISA Kits)-RUNX1 (show RUNX1 ELISA Kits).

  5. Deliver the necessary promotional drive for the progression of ETV6 (show ETV6 ELISA Kits)-RUNX1 (show RUNX1 ELISA Kits)+ pre-leukaemic cells.

  6. High RUNX1 (show RUNX1 ELISA Kits) expression is associated with pancreatic cancer.

  7. these findings have identified a novel function for Runx1 (show RUNX1 ELISA Kits) in sustaining normal mammary epithelial morphology and preventing epithelial-mesenchymal transition

  8. Leukaemogenesis by AML1 (show RUNX1 ELISA Kits)-ETO (show RUNX1T1 ELISA Kits) requires enhanced C/D box snoRNA/RNP (show RNPC3 ELISA Kits) formation.

  9. The expression of EVI1 and SOX9 (show SOX9 ELISA Kits) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (show FRAP1 ELISA Kits) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (show FRAP1 ELISA Kits) targeting failure

  10. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (show F2 ELISA Kits)-activatable receptor PAR-1 (protease-activated receptor-1 (show F2R ELISA Kits)), in Runx1 (show RUNX1 ELISA Kits)/Cbfb (show CBFB ELISA Kits)-deleted MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits) cells. Similar to the effect of Runx1 (show RUNX1 ELISA Kits)/Cbfb (show CBFB ELISA Kits) deletion, PAR-1 (show MARK2 ELISA Kits) overexpression induced CDKN1A/p21 (show CDKN1A ELISA Kits) expression and attenuated proliferation in MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits) cells

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Gata2 (show GATA2 ELISA Kits) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  2. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  3. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (show CEBPA ELISA Kits) from EVI1-induced suppression.

  4. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 ELISA Kits), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 ELISA Kits) levels.

  5. Survivin (show BIRC5 ELISA Kits) partially regulates HSC (show FUT1 ELISA Kits) function by modulating the Evi-1 transcription factor and its downstream targets

  6. Thrombopoietin (show THPO ELISA Kits)/MPL (show MPL ELISA Kits) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  7. Prdm16 (show PRDM16 ELISA Kits) and Prdm3 control postnatal BAT (show BAAT ELISA Kits) identity and function.

  8. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  9. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL ELISA Kits)) fusion protein (MFP) leukemia

  10. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (show CEBPB ELISA Kits), liver inhibitory protein (LIP), induced acute myeloid leukemia (show BCL11A ELISA Kits) with short latencies in a mouse bone marow transplantation model.

MDS1 and EVI1 Complex Locus (MECOM) Antigen Profile

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom) antibody
  • MDS1 and EVI1 complex locus (MECOM) antibody
  • MDS1 and EVI1 complex locus (LOC100343228) antibody
  • MDS1 and EVI1 complex locus (Mecom) antibody
  • runt-related transcription factor 1 (RUNX1) antibody
  • AML1 antibody
  • AML1-EVI-1 antibody
  • AMLCR1 antibody
  • CBFA2 antibody
  • D630039M04Rik antibody
  • EVI-1 antibody
  • Evi1 antibody
  • im:7140716 antibody
  • Jbo antibody
  • Mds antibody
  • Mds1 antibody
  • Mds1-Evi1 antibody
  • PEBP2aB antibody
  • Prdm3 antibody
  • Znfpr1b1 antibody

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPECIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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