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HLA-A belongs to the HLA class I heavy chain paralogues. Additionally we are shipping HLA-A Antibodies (130) and HLA-A Kits (3) and many more products for this protein.
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Vitiligo risk associated with the MHC class I region thus derives from combined quantitative and qualitative phenomena: a SNP haplotype in a transcriptional regulator that induces gain-of-function, elevating expression of HLA-A RNA
Promiscuous Recognition of a Trypanosoma cruzi CD8 (show CD8A Proteins)+ T Cell Epitope among HLA-A2, HLA-A24 (show CD164 Proteins) and HLA-A1 Supertypes in Chagasic Patients.
HLA-A*31:01 was confirmed to be significantly associated with definite/probable cases of Stevens-Johnson syndrome/toxic epidermal necrolysis
The HLA-DRB1*15 allele, the A*01/B*08/DRB1*03 haplotypes, and the homozygosity of HLA-A*01 and HLA-A*02 may play a presumptive predisposing factor in Acute Myeloblastic Leukemia.
expression on melanoma variants with B-Raf (show SNRPE Proteins) kinase inhibitors plays a major role in their susceptibility to NK-cell cytotoxicity
HLA-A* 02:07 is likely an important genetic risk factor for postmenopausal osteoporosis in the Han Chinese population.
HLA-A alleles are associated with dermatitis herpetiformis in Chinese population.
Results demonstrate that HLA-A*02 mediates a modest, but none the less stronger, EBV-specific CD8(+) T cell response than non-HLA-A*02 alleles.
HLA-A*02:06 with Toll Like Receptor 3 polymorphisms and HLA-A*02:06 with prostaglandin e receptor-3 polymorphisms exerted additive effects in Stevens-Johnson Syndrome with Surface Ocular Complications
These data demonstrate HLA-A allelic lineage-specific variation in expression levels, and DNA methylation (show HELLS Proteins) as a likely factor in contributing to this variation.
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
HLA class I histocompatibility antigen, A-1 alpha chain
, MHC class I antigen HLA-A heavy chain
, antigen presenting molecule
, leukocyte antigen class I-A