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The membrane-associated protein encoded by Mod2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping Malic Enzyme Complex, Mitochondrial Proteins (8) and many more products for this protein.
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ABCB1 polymorphisms may contribute to the blood pressure variation in Han Chinese population and the effect may be specific in females
SMS (show SMS Antibodies) regulates the expression and function of drug transporters P-gp (show ABCB4 Antibodies) and MRP2 (show ABCC2 Antibodies).
BZML is a novel colchicine binding site inhibitor and overcomes multi-drug resistance in A549/Taxol cells by inhibiting P-gp (show ABCB4 Antibodies) function and inducing mitotic catastrophe.
We have noted that the implication of C3435T variant on the risk of breast cancer was ethnicity-dependent. However, there is no evidence that ABCB1 (show ABCB1 Antibodies) C3435T polymorphism could play a role in susceptibility to breast cancer in Morocco.
no significant clinical relevance between Pgp expression and osteosarcoma survival
Meta-analysis found no evidence for ABCB1 (show ABCB1 Antibodies) C3435T and C1236T polymorphisms as risk factors for pediatric Acute Lymphoblastic Leukemia.
ABCB1 (show ABCB1 Antibodies) gene polymorphisms in association with others risk factors contribute to anti-TB drug resistance, mainly ethambutol.
For the first time, we demonstrated that MDR1 (show TBC1D9 Antibodies) rs1128503 polymorphisms were associated with systemic lupus erythematosus susceptibility in Chinese Guangxi population.
multiple pathways, including MMP9 (show MMP9 Antibodies) cleavage and ubiquitinylation, mediated P-gp (show ABCB4 Antibodies) downmodulation.
We also determined the effect of Pygo2 on the sensitivity of breast tumors resistant to doxorubicin in a mouse model. Finally, RNA samples from 64 paired patient tumors (before and after chemotherapy) highly and significantly overexpressed Pygo2 and/or MDR1 after treatment, thus underlining a pivotal role for the Pygo2-mediated Wnt/b-catenin pathway in the clinical chemoresistance of breast cancer.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
malic enzyme complex, mitochondrial
, malic enzyme, mitochondrial regulatory
, malic enzyme, mitochondrial structural
, P-glycoprotein 1
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1