Membrane Frizzled-Related Protein Proteins (MFRP)

MFRP encodes a member of the frizzled-related proteins. Additionally we are shipping MFRP Antibodies (22) and MFRP Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MFRP 83552 Q9BY79
Rat MFRP MFRP 315597  
MFRP 259172 Q8K480
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Top MFRP Proteins at

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

MFRP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

More Proteins for Membrane Frizzled-Related Protein (MFRP) Interaction Partners

Human Membrane Frizzled-Related Protein (MFRP) interaction partners

  1. The current study expands our knowledge of the mutation spectrum of MFRP and its associated phenotypes. To our knowledge, this is the first report of MFRP mutations in a Chinese cohort.

  2. Among five single nucleotide polymorphism(SNP)s tested, only MFRP rs3814762 and heat shock protein (HSP)70 (show HSP70 Proteins) rs1043618 show nominal association with primary angle closure.

  3. nanophthalmos and high hyperopia but without electrophysiological evidence of retinal dystrophy (show MERTK Proteins) has also been associated with MFRP mutations.

  4. Corneal diameter decreases with decreasing axial length, suggesting posterior microphthalmos and nanophthalmos represent a spectrum of high hyperopia rather than distinct phenotypes. In the Saudi population PRSS56 mutations are the major cause.

  5. Homozygous autosomal recessive retinitis pigmentosa-causing mutations have been found in three Indian families. These included a single base deletion in MFRP.

  6. MFRP gene shows tendency to be associated with primary angle closure glaucoma in both the Australian and Nepalese cohorts.

  7. Posterior microphthalmos can be caused by nonsense compound heterozygous mutations in the MFRP gene.

  8. In both previous reports of PMPRS, mutations in membrane type frizzled-related protein (MFRP) gene (located at 11q23) was demonstrated to be present

  9. Three novel MFRP mutations that expand the phenotypic data available on patients with MFRP mutations, are reported.

  10. Extreme hyperopia (Nanophthalmos) is the result of null mutations in MFRP.

Mouse (Murine) Membrane Frizzled-Related Protein (MFRP) interaction partners

  1. Transcripts of Prss56, a gene associated with angle-closure glaucoma, posterior microphthalmia and myopia, were increased in Mfrprd6 eyes by 17-fold.

  2. the severity of the Mfrp(rd6) retinal degenerative phenotype in mice depends on the strain genetic background and that a significant modifier locus on CAST/EiJ Chromosome 1 protects against Mfrp(rd6)-associated photoreceptor loss.

  3. The authors have identified a novel null mutation in mouse Mfrp. This mutation causes photoreceptor degeneration and eventual RPE (show RPE Proteins) atrophy, which may be related to alterations in the number of RPE (show RPE Proteins) microvilli.

  4. involvement of the Mfrp gene expressed by retinal pigment epithelium in the degeneration of photoreceptors

MFRP Protein Profile

Protein Summary

This gene encodes a member of the frizzled-related proteins. The encoded protein may play a role in eye development, as mutations in this gene have been associated with nanophthalmos, posterior microphthalmia, retinitis pigmentosa, foveoschisis, and optic disc drusen. The protein is encoded by a bicistronic mRNA, which also encodes C1q and tumor necrosis factor related protein 5.

Gene names and symbols associated with MFRP

  • membrane frizzled-related protein (MFRP)
  • membrane frizzled-related protein (LOC100338785)
  • membrane frizzled-related protein (Mfrp)
  • membrane-type frizzled-related protein (Mfrp)
  • MCOP5 protein
  • MFRP protein
  • NNO2 protein
  • rd6 protein

Protein level used designations for MFRP

membrane frizzled-related protein , membrane frizzled-related protein-like , membrane-type frizzled-related protein

451609 Pan troglodytes
704965 Macaca mulatta
100071432 Equus caballus
100338785 Oryctolagus cuniculus
100398152 Callithrix jacchus
100454727 Pongo abelii
100465638 Ailuropoda melanoleuca
100597354 Nomascus leucogenys
83552 Homo sapiens
489366 Canis lupus familiaris
522979 Bos taurus
315597 Rattus norvegicus
259172 Mus musculus
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