Methyltransferase Like 3 (METTL3) ELISA Kits

METTL3 encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. Additionally we are shipping METTL3 Antibodies (24) and METTL3 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
METTL3 56339 Q86U44
METTL3 56335 Q8C3P7
Anti-Rat METTL3 METTL3 361035  
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More ELISA Kits for METTL3 Interaction Partners

Human Methyltransferase Like 3 (METTL3) interaction partners

  1. methylation at m6A (show GPM6A ELISA Kits) by METTL3/METTL14 (show METTL14 ELISA Kits) facilitates the methylation of m5C by NSUN2 (show NSUN2 ELISA Kits), and vice versa. NSUN2 (show NSUN2 ELISA Kits)-mediated m5C and METTL3/METTL14 (show METTL14 ELISA Kits)-mediated m6A (show GPM6A ELISA Kits) methylation synergistically enhance p21 (show CDKN1A ELISA Kits) expression at the translational level

  2. loss of METTL3 leads to increased levels of phosphorylated AKT (show AKT1 ELISA Kits), which contributes to the differentiation-promoting effects of METTL3 depletion. Overall, these results provide a rationale for the therapeutic targeting of METTL3 in myeloid leukemia (show BCL11A ELISA Kits)

  3. The structure reveals the heterodimeric architecture of the complex and donor substrate binding by METTL3. Structure-guided mutagenesis indicates that METTL3 is the catalytic subunit of the complex, whereas METTL14 (show METTL14 ELISA Kits) has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and substrate RNA binding.

  4. For the methylation of adenosine in RNA, Mettl3 is the catalytically active subunit, while Mettl14 (show METTL14 ELISA Kits) plays a structural role critical for substrate recognition.

  5. METTL3 enhances mRNA translation through an interaction with the translation initiation machinery in lung adenocarcinoma cells.

  6. miR (show MLXIP ELISA Kits)-33a can attenuatenon-small-cell lung carcinoma cells proliferation via targeting to the 3'-untranslated region of METTL3 mRNA.

  7. Structure of the METTL3-METTL14 (show METTL14 ELISA Kits) complex

  8. Study identifies m(6)A methylation sites on many clock gene transcripts and shows that specific inhibition of m(6)A methylation by silencing of the m(6)A methylase Mettl3 is sufficient to elicit circadian period elongation and RNA processing delay.

Mouse (Murine) Methyltransferase Like 3 (METTL3) interaction partners

  1. this study identifies Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naive pluripotency.

METTL3 Antigen Profile

Antigen Summary

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.

Gene names and symbols associated with METTL3

  • methyltransferase like 3 (mettl3) antibody
  • methyltransferase like 3 L homeolog (mettl3.L) antibody
  • methyltransferase like 3 (METTL3) antibody
  • methyltransferase like 3 (Mettl3) antibody
  • methyltransferase-like 3 (Mettl3) antibody
  • 2310024F18Rik antibody
  • fj82g07 antibody
  • IME4 antibody
  • M6A antibody
  • MT-A70 antibody
  • Spo8 antibody
  • wu:fj82g07 antibody
  • zgc:77093 antibody

Protein level used designations for METTL3

N6-adenosine-methyltransferase 70 kDa subunit , adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase , mRNA m(6)A methyltransferase , methyltransferase-like protein 3 , MT-A70 , m6a methyltransferase , methyltransferase-like 3

100004398 Danio rerio
414662 Xenopus laevis
56339 Homo sapiens
475404 Canis lupus familiaris
540339 Bos taurus
56335 Mus musculus
361035 Rattus norvegicus
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