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The protein encoded by MFN1 is a mediator of mitochondrial fusion. Additionally we are shipping Mitofusin 1 Antibodies (135) and Mitofusin 1 Proteins (11) and many more products for this protein.
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The results showed that high level of Mfn1 expression significantly improved the embryo development rates by increasing ATP level and Deltapsim, while reducing H(2)O(2) generation.
crystal structures of engineered human MFN1 containing the GTPase (show RACGAP1 ELISA Kits) domain and a helical domain during different stages of GTP (show AK3 ELISA Kits) hydrolysis; mechanistic model for MFN1-mediated mitochondrial tethering is proposed; results shed light on the molecular basis of mitochondrial fusion and mitofusin (show MFN2 ELISA Kits)-related human neuromuscular disorders
These results suggest that MFN (show TLL1 ELISA Kits) tethers apposing membranes, likely through nucleotide-dependent dimerization.
Improper transcriptional (in)activation of mitofusin-1 and dynamin-related protein 1 (show DNM1L ELISA Kits) during early in vitro embryo development is associated with a decrease in mitochondrial membrane potential and with embryo fragmentation.
A fine balance of Mfn1 levels is maintained by MARCH5 (show MARCH5 ELISA Kits)-mediated quality control on acetylated Mfn1.
miR (show MLXIP ELISA Kits)-19b targets 3'UTR (show UTS2R ELISA Kits) sequences of Mfn1 genes inhibit the expression of Mfn1
In a amyotrophic lateral sclerosis transgenic mouse model, Mfn1 is significantly increased in spinal cord.
A novel role for the endoplasmic reticulum-associated Gp78 (show AMFR ELISA Kits) ubiquitin ligase and the Mfn1 mitochondrial fusion factor in mitophagy.
Knock-out of mitofusin (show MFN2 ELISA Kits) protein Mfn1 increased the frequency of mitochondrial fission with increased lifetime of unpaired events whereas deletion of both Mfn1 and Mfn2 (show MFN2 ELISA Kits) resulted in an instable dynamics.
These results collectively suggest a role for Mfn1 in regulating the activation of Bax (show BAX ELISA Kits) on the outer mitochondrial membrane in a GTPase (show RACGAP1 ELISA Kits)-dependent manner.
Patterned Purkinje cell degeneration (show AGTPBP1 ELISA Kits) is dependent on caspase (show CASP3 ELISA Kits) activation, leading to the marked decrease of mitofusion 1 in the transgeni (show AIFM1 ELISA Kits)c Harlequin cerebellum.
We found that mouse embryonic fibroblasts lacking Mfn2 (show MFN2 ELISA Kits) have altered lipid droplet morphology. However, triacylglycerol biosynthesis was not dependent on ER-mitochondrial tethering mediated by mitofusins. Lastly, Mfn2 (show MFN2 ELISA Kits) does not have a role in adipocyte differentiation.
MFN1 deficiency leads to defects in mitochondrial activity and male infertility.
Report exposes a novel role for Shh (show SHH ELISA Kits) in regulating mitochondrial dynamics and rescue the metabolic profile of tumor cells through regulation of mitofusin 1 and 2.
Ablating Mfn1 eliminates the cardiac-related lethality of Mff (show MFF ELISA Kits) knockout mice.
Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: Mfn1, Mfn2 (show MFN2 ELISA Kits), OPA1 (optic atrophy 1 (show OPA1 ELISA Kits) protein), and Drp1 (dynamin 1-like protein (show DNM1L ELISA Kits)). [REVIEW]
Authors present evidence that metabolically challenged mitochondria undergo active fusion to suppress oxidative stress. In response to glucose starvation, mitofusin 1 (MFN1) becomes associated with the protein deacetylase HDAC6 (show HDAC6 ELISA Kits).
These findings suggest that mitochondrial impairment is a very early event in Alzheimer disease pathogenesis and abnormal expression of Mfn1 and Mfn2 (show MFN2 ELISA Kits) caused by excessive intracellular Abeta (show APP ELISA Kits) is the possible molecular mechanism.
Data identify MFN1 as an ERK (show EPHB2 ELISA Kits) target to modulate mitochondrial shape and apoptosis.
Mitochondrial shape governs BAX (show BAX ELISA Kits)-induced membrane permeabilization and apoptosis via Mfn1.
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.
, mitofusin 2
, fzo homolog
, mitochondrial transmembrane GTPase FZO-2
, mitochondrial transmembrane GTPase Fzo-1
, putative transmembrane GTPase
, transmembrane GTPase MFN1
, mitochondrial transmembrane GTPase FZO1B