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Myosin Binding Protein C, Cardiac Proteins (MYBPC3)

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Additionally we are shipping MYBPC3 Antibodies (58) and MYBPC3 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYBPC3 17868  
Rat MYBPC3 MYBPC3 295929 P56741
MYBPC3 4607 Q14896
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Top MYBPC3 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

MYBPC3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Myosin Binding Protein C, Cardiac (MYBPC3) Interaction Partners

Cow (Bovine) Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. N terminus of cMyBP-C interacts with F-actin through multiple distinct binding sites and that binding at one or more sites is reduced by phosphorylation

Mouse (Murine) Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. MYBPC3 mutations is elevated oxidative stress that corresponded to severe cardiac dysfunction, myocyte damage, and myocardial remodeling.

  2. MBPC and troponin-I phosphorylation modulate myofilament length-dependent activation

  3. MYBPC has unexpected inhibitory functions during postnatal myocyte cytokinesis and cell cycle progression.

  4. Haploinsufficiency occurs in heterozygote MYBPC3 mutant carriers.

  5. cMyBP-C is a principal mediator of increased contractility observed with beta-adrenergic stimulation or increased pacing because of protein kinase A and CaMKIIdelta phosphorylations of cMyB (show MYB Proteins)-C.

  6. Data suggest that cardiac myosin binding protein C (cMyBP-C) is an allosteric activator of myosin to increase cross-bridge force, and its phosphorylation status modulates the force.

  7. Mybpc3 S282A mice displayed normal basal in vivo cardiac function but impaired rates of pressure development in response to beta-adrenergic stimulation.

  8. Amptomatic heterozygous MYBPC3 carriers do suffer impairments that may presage the onset of hypertrophic cardiomyopathy.

  9. Mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein (show TNNT2 Proteins) expression.

  10. Data indicate that slow and fast skeletal muscles in myosin binding (show PPP1R12A Proteins) protein-C (show PROC Proteins) cMyBP-C((t/t)) mice showed no histological or ultrastructural changes in comparison to the wild-type control.

Human Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. 5 out of 102 (4.9%) athletes carried mutations: a heterozygous MYH7 (show MYH7 Proteins) Glu935Lys mutation, a heterozygous MYBPC3 Arg160Trp mutation and another heterozygous MYBPC3 Thr1046Met mutation, all of which had been reported as HCM-associated mutations

  2. a significant role of MYBPC3 gene mutations in Hypertrophic cardiomyopathy(HCM) disease and can be used for pre-symptomatic diagnosis of at risk family members of affected individuals.

  3. Atrial fibrillation occurred in 74 patients with hypertrophic cardiomyopathy (31%), but with no difference among genotype groups (31% in MYBPC3, 37% in MYH7 (show MYH7 Proteins) and 18% in other genotypes, p = 0.15).

  4. The detection of MYBPC3 mutation, especially the PTC (show F9 Proteins) mutation and double-mutation, may serve as a molecular marker for clinical risk stratification of HCM.

  5. Demonstrate that MYBPC3 gene mutations, revealed by next-generation sequencing, were associated with familial and sporadic restrictive cardiomyopathy phenotype in patients.

  6. Data indicate that homozygous or compound heterozygous truncating pathogenic myosin binding (show PPP1R12A Proteins) protein C (MYBPC3) mutations cause severe neonatal cardiomyopathy with features of left ventricular noncompaction and septal defects.

  7. Mutations in the MYBPC3 and CASQ2 (show CASQ2 Proteins) genes and six combinations between loci in the MYBPC3, MYH7 (show MYH7 Proteins) and CASQ2 (show CASQ2 Proteins) genes were responsible for cardiomyopathy risk in a studied cohort.

  8. Although females with MYBPC3 mutations showed later onset of hypertrophic cardiomyopathy, female patients were more symptomatic at diagnosis and had more frequent heart failure events once they had developed hypertrophy.

  9. A founder MYBPC3 mutation results in HCM with a high risk of sudden death after the fourth decade of life

  10. Mutations in MYBPC3 are associated with cardiomyopathy. [Review]

Rabbit Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. small es, CyrillicMyBP-C modulates interaction of myosin with actin

MYBPC3 Protein Profile

Protein Summary

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.

Gene names and symbols associated with MYBPC3

  • myosin binding protein C, cardiac (mybpc3)
  • myosin binding protein C, cardiac (MYBPC3)
  • myosin binding protein C, cardiac (LOC100220915)
  • myosin binding protein C, cardiac (Mybpc3)
  • myosin binding protein C, cardiac (LOC100346773)
  • CMH4 protein
  • FHC protein
  • hm:zehn0716 protein
  • im:6900815 protein
  • MGC114614 protein
  • MYBP-C protein
  • zgc:152717 protein
  • zgc:158442 protein

Protein level used designations for MYBPC3

myosin binding protein C, cardiac , cardiac myosin-binding protein C , protein C, cardiac , myosin-binding protein C, cardiac-type , cardiac myosin binding protein C , myosin-binding protein C, cardiac-type-like , C-protein, cardiac muscle isoform , cardiac C-protein , cardiac MyBP-C

398261 Xenopus laevis
451168 Pan troglodytes
483624 Canis lupus familiaris
556489 Danio rerio
767614 Bos taurus
100105196 Felis catus
100127177 Xenopus (Silurana) tropicalis
100220915 Taeniopygia guttata
100452875 Pongo abelii
17868 Mus musculus
295929 Rattus norvegicus
4607 Homo sapiens
396013 Gallus gallus
100512088 Sus scrofa
100346773 Oryctolagus cuniculus
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