Myosin Binding Protein C, Cardiac Proteins (MYBPC3)

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Additionally we are shipping MYBPC3 Antibodies (65) and MYBPC3 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYBPC3 17868  
Rat MYBPC3 MYBPC3 295929 P56741
MYBPC3 4607 Q14896
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Top MYBPC3 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
HOST_Escherichia coli (E. coli) Human GST tag,His tag   100 μg Log in to see 15 to 18 Days

MYBPC3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Myosin Binding Protein C, Cardiac (MYBPC3) Interaction Partners

Cow (Bovine) Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. N terminus of cMyBP-C interacts with F-actin through multiple distinct binding sites and that binding at one or more sites is reduced by phosphorylation

Mouse (Murine) Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. autophagy is impaired in Mybpc3-targeted knockin mice

  2. these data indicate a robust proinflammatory response in DCM hearts, likely in response to cellular damage triggered by MYBPC3 mutation and resultant contractile dysfunction.

  3. We provide evidence that haploinsufficiency and poison polypeptide hypotheses are disease mechanisms and that EHTs can be used as a platform to evaluate the direct impact of (newly identified) MYBPC3 gene variants.

  4. These results support the proposal that cMyBP-C stabilises the thick filament and that the loss of cMyBP-C results in an untethering of myosin heads.

  5. Crypts are a normal part of cardiac development but, along with the mitral valve and trabeculae, their developmental trajectory is altered by the presence of HCM truncating Mybpc3 gene mutation

  6. that in the homozygous hypertrophic cardiomyopathy mouse model, beta-AR stimulation leads to preferential PKA phosphorylation of phospholamban over cardiac troponin I, resulting in an impaired inotropic and lusitropic response

  7. Phosphorylation of MYBPC3 contributes to the genesis of ventricular wall geometry, linking myofilament biology with multiscale cardiac mechanics and myoarchitecture.

  8. The cMyBP-C hypertrophic cardiomyopathy variant L348P enhances thin filament activation through an increased shift in tropomyosin (show TPM2 Proteins) position.

  9. The contributions of cardiac myosin binding protein C and troponin I phosphorylation to beta-adrenergic enhancement of in vivo cardiac function

  10. MYBPC3 mutations is elevated oxidative stress that corresponded to severe cardiac dysfunction, myocyte damage, and myocardial remodeling.

Human Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. Study showed that CACNB2 (show CACNB2 Proteins) is a possible candidate hypertrophy-modifying gene contributing to disease variability of MYBPC3-associated familial hypertrophic cardiomyopathy

  2. The authors demonstrate myosin tail (S2)-dependent functional regulation of actin-activated human beta-cardiac myosin ATPase. In addition, they show that both S2 and MyBP-C bind to S1 and that phosphorylation of either S1 or MyBP-C weakens these interactions.

  3. Our study supports that mutations in MYH7 (show MYH7 Proteins) and MYBPC3 should be the first focus of moleculargenetic analysis in HCM, and that mutations in TNNT2 (show TNNT2 Proteins) have a low prevalence in Brazilian population. All mutations detected were missense mutations, whereas two mutations in MYH7 (show MYH7 Proteins) had not been described before.

  4. These findings point to the critical role of MYBPC3 during sarcomere assembly in cardiac myocyte differentiation and suggest developmental influences of MYBPC3 truncating mutations on the mature hypertrophic phenotype.

  5. Study shows lack of phenotypic differences between MYH7 (show MYH7 Proteins)- and MYBPC3-associated hypertrophic cardiomyopathy when assessed by cardiac magnetic resonance imaging.

  6. MYBPC3 and MYH7 (show MYH7 Proteins) were the most common mutated genes, accounting for 27% of the total Hypertrophic Cardiomyopathy patients and 83% of the putative mutations in the main sarcomeric genes.

  7. MYBPC3 gene mutation is associated with Early-Onset Hypertrophic Cardiomyopathy.

  8. The results showed that MYBPC3 25-bp deletion polymorphism was significantly associated with elevated risk of left ventricular dysfunction (LVD), while TTN 18 bp I/D, TNNT2 5 bp I/D and myospryn K2906N polymorphisms did not show any significant association with LVD.

  9. we report a patient presenting with a complex phenotype consisting of severe, adult-onset, dilated cardiomyopathy, hearing loss and developmental delay, in which exome sequencing revealed two genetic variants that are inherited from a healthy mother: a variant, in MYBPC3, that is associated with hereditary cardiomyopathy.

  10. 5 out of 102 (4.9%) athletes carried mutations: a heterozygous MYH7 (show MYH7 Proteins) Glu935Lys mutation, a heterozygous MYBPC3 Arg160Trp mutation and another heterozygous MYBPC3 Thr1046Met mutation, all of which had been reported as HCM-associated mutations

Rabbit Myosin Binding Protein C, Cardiac (MYBPC3) interaction partners

  1. small es, CyrillicMyBP-C modulates interaction of myosin with actin

MYBPC3 Protein Profile

Protein Summary

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.

Gene names and symbols associated with MYBPC3

  • myosin binding protein C, cardiac (mybpc3)
  • myosin binding protein C, cardiac (MYBPC3)
  • myosin binding protein C, cardiac (LOC100220915)
  • myosin binding protein C, cardiac (Mybpc3)
  • myosin binding protein C, cardiac (LOC100346773)
  • CMH4 protein
  • FHC protein
  • hm:zehn0716 protein
  • im:6900815 protein
  • MGC114614 protein
  • MYBP-C protein
  • zgc:152717 protein
  • zgc:158442 protein

Protein level used designations for MYBPC3

myosin binding protein C, cardiac , cardiac myosin-binding protein C , protein C, cardiac , myosin-binding protein C, cardiac-type , cardiac myosin binding protein C , myosin-binding protein C, cardiac-type-like , C-protein, cardiac muscle isoform , cardiac C-protein , cardiac MyBP-C

398261 Xenopus laevis
451168 Pan troglodytes
483624 Canis lupus familiaris
556489 Danio rerio
767614 Bos taurus
100105196 Felis catus
100127177 Xenopus (Silurana) tropicalis
100220915 Taeniopygia guttata
100452875 Pongo abelii
17868 Mus musculus
295929 Rattus norvegicus
4607 Homo sapiens
396013 Gallus gallus
100512088 Sus scrofa
100346773 Oryctolagus cuniculus
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