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Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein p78 (Mouse) Proteins (MX1)

In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. Additionally we are shipping MX1 Antibodies (105) and MX1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MX1 24575  
MX1 17857 P09922
MX1 4599 P20591
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Top MX1 Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

MX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

Human , ,

More Proteins for Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein p78 (Mouse) (MX1) Interaction Partners

Mouse (Murine) Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein p78 (Mouse) (MX1) interaction partners

  1. Mouse Mx1 was shown to be essential for interferon (show IFNA Proteins) type I-dependent protective immunity against primary influenza. (Review)

  2. In Mx1-intact mice with weakened resistance due to deficiencies in Mavs (show MAVS Proteins) and Tlr7 (show TLR7 Proteins), an elevated respiratory bacterial burden was found.

  3. Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses.

  4. we show that, very unexpectedly, congenic D2-Mx1(r/r) mice carrying the wild-type Mx1 gene from the A2G strain are not fully protected against lethal influenza virus infections

  5. dysregulated gene transcriptional activity corresponded to persistent induction of cytokine/chemokines and recruitment of cytokine-producing cells that promote inflammation in B6-Mx1(-/-) mouse lungs.

  6. Mice with a functional Mx1 generate a strong antiviral state by downregulating key modulator molecules associated with influenza virus lethality.

  7. functional Mx1 did not alter olfactory bulb invasion by virus but attenuated illness compared to knockout Mx1 mice

  8. nuclear MxA suppresses the influenza virus transcription by interacting not only with RNA polymerase subunit PB2 but also with influenza NP

  9. Thogoto virus mutant lacking protein ML was strongly attenuated in mice carrying the interferon (show IFNA Proteins)-responsive Mx1 gene

  10. A variant of influenza A virus strain A/PR/8/34 (H1N1) exhibits normal sensitivity to growth restriction by Mx1; the virus is well controlled in Mx1-expressing but not Mx1-null mice.

Human Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein p78 (Mouse) (MX1) interaction partners

  1. A significant association was observed between MX1 -88G/T SNP and susceptibility to systemic lupus erythematosus

  2. Study shows different levels of expression of MxA in each breast cancer subtype and its close relationship with tumor-infiltrating lymphocytes. MxA protein expression was higher in triple-negative breast cancer and correlated with a higher histologic grade.

  3. This study demonstrated that MxA mRNA expression of interferon beta (show IFNB1 Proteins) response in multiple sclerosis patients.

  4. Transient dimerization of human MxA promotes GTP (show AK3 Proteins) hydrolysis.The GTPase (show RACGAP1 Proteins) domains of Mx proteins dimerize transiently to facilitate catalysis.

  5. polymorphism at position -88 in the MxA promoter region might be a potential biomarker to predict HCV progression toward end-stage fibrosis and response to IFN-based therapy in chronic hepatitis C patients.

  6. data suggest that, during infection, a fraction of MxA disassembles into dimers that bind to NP synthesized following primary transcription in the cytoplasm, thereby preventing viral replication

  7. heterozygosity for both -88G/T and -123C/A polymorphisms of the MxA gene is important host factor that influence the response to IFN therapy in patients with chronic HCV infection.

  8. E2F1 (show E2F1 Proteins) transcripts and miR-17-5p were significantly downregulated while c-Myc (show MYC Proteins) and MxA transcripts were significantly upregulated in SLE.

  9. Baseline MxA mRNA levels may be useful for predicting whether multiple sclerosis patients will respond or not to interferon-beta (show IFNB1 Proteins) treatment.

  10. Blood MxA protein levels are increased in young children with symptomatic respiratory virus infections, including rhinovirus infections. MxA is an informative general marker for the most common acute virus infections.

Pig (Porcine) Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein p78 (Mouse) (MX1) interaction partners

  1. The deletion/insertion polymorphism in exon 14 of the Mx1 gene, which causes a frame shift, showed no significant association with growth or viremia after PRRSV infection.

  2. the SINE insertion polymorphism at site -547 of the MX1 gene promoter region is a potential DNA marker for porcine reproductive and respiratory syndrome resistance

  3. Overexpression of porcine Mx1 induce a robust immune response against foot-and-mouth disease virus.

  4. Studied the effects of porcine Mx1 protein on FMDV and BVDV replication by measuring viral reverse transcriptase activity at various time intervals.

  5. Polymorphisms in Mx1 are significantly associated with immunological traits in Landrace piglets and have potential application value for marker-assisted selection of pig breeding with disease resistance.

  6. Porcine Mx1 protein inhibits replication of influenza A virus, and impairs the traffic of the endocytic vesicles to the late endosomes.

  7. The 11-bp deletion Mx1 mutant is lacking antiviral activity able to contribute to the interference of influenza virus replication.

  8. Data showed that there were abundant MX1 gene polymorphisms in all pig breeds.

  9. Sequencing of the 332-bp MX1 promoter region identified 15 substitutions and insertions at three positions in 21 pigs from 15 breeds, in which nine genotypes were classified.

Cow (Bovine) Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein p78 (Mouse) (MX1) interaction partners

  1. MX1-a, MX1B and MX2 (show MX2 Proteins) are affected by the type I IFN pathway during pregnancy and are involved in an immune response to protect the mother and fetus

  2. The replication levels of foot-and-mouth disease virus RNA were promoted by silencing bovine Mx1.

  3. Overexpression of bovine Mx1 protein inhibits the replication of foot-and-mouth disease virus.

  4. Data indicate that the expression profiles of ISG15 (show ISG15 Proteins), MX1, MX2 (show MX2 Proteins), and OAS1 (show OAS1 Proteins) could be a useful diagnostic biomarker of gestation.

  5. The proximal GC boxes were found to be essential for IFN response in the bovine Mx1 promoter with the deletion mutants.

  6. Mx1 is cytoplasmic. Mx1B is mainly nuclear. An Arg-rich nuclear localization signal was found in 27 AAs (show FGD1 Proteins) specific for Mx1B. N-terminus-deleted Mx1B is only cytoplasmic. The deleted-Mx1B-expressing cells had positive antiviral activity against VSVDeltaG*-G.

  7. A new bovine Mx gene (designated Mx1B) was isolated from the endometrial cDNA library of the early pregnant cow.

MX1 Protein Profile

Protein Summary

In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with MX1

  • myxovirus (influenza virus) resistance 1 (Mx1)
  • myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1)
  • AI893580 protein
  • IFI-78K protein
  • IFI78 protein
  • MX protein
  • Mx-1 protein
  • Mx1-b protein
  • Mx1B protein
  • MxA protein
  • OGTPBP protein
  • ONBP protein

Protein level used designations for MX1

Myxovirus (influenza) resistance homolog of murine Mx (also interferon-inducible protein IFI78) , Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78) , interferon-induced GTP-binding protein Mx1 , myxoma resistance protein 1 , myxovirus resistance protein 1 , myxovirus (influenza) resistance 1 polypeptide , interferon-regulated resistance GTP-binding protein MxA , GTP-binding protein , interferon-inducible myxovirus resistance-1 protein , interferon-inducible protein p78 , myxovirus (influenza) resistance 1, (murine homolog) , GTP-binding protein Mx1 , oligodendrocyte GTP-binding protein , oligodendrocyte nucleotide-binding protein

24575 Rattus norvegicus
17857 Mus musculus
4599 Homo sapiens
397128 Sus scrofa
280872 Bos taurus
403745 Canis lupus familiaris
715186 Macaca mulatta
443146 Ovis aries
100034192 Equus caballus
100174697 Pongo abelii
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