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Neurexin 1 Proteins (NRXN1)

Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Additionally we are shipping Neurexin 1 Antibodies (63) and Neurexin 1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat NRXN1 NRXN1 60391 Q63372
NRXN1 9378 Q9ULB1 , P58400
NRXN1 18189 Q9CS84
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Top Neurexin 1 Proteins at

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

NRXN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,

More Proteins for Neurexin 1 (NRXN1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Neurexin 1 (NRXN1) interaction partners

  1. DNRX was expressed preferentially in central and motor neurons in embryos, larvae and adults, but not in glial cells. DNRX was expressed in pre- and post-synaptic areas in third instar larvae neuromuscular junctions.

  2. presynaptic spinophilin (show PPP1R9B Proteins) fine-tunes neurexin/neuroligin signalling to control active zone number and functionality

  3. The intracellular region of NRX interacts with N-ethylmaleimide-sensitive factor (show NSF Proteins). This interaction regulates short term synaptic depression.

  4. cooperation between Syd-1 and Nrx-1 seems to orchestrate early assembly processes between pre- and postsynaptic membranes

  5. Neurexin-1 null mutants exhibit associative learning defect in larvad.

  6. DNRX is essential for synaptic vesicle cycling, which plays critical roles in neurotransmission at neuromuscular junctions (NMJ).

Human Neurexin 1 (NRXN1) interaction partners

  1. Results demonstrate that NRXN1 alternative isoform expression is temporally regulated during critical periods of human neocortical development and identify potential differential molecular contributions of NRXN1-alpha and -beta to schizophrenia and bipolar disorder

  2. the top-ranked discordances were subsequently selected for validation by quantitative polymerase chain reaction (qPCR), from which one single ~120kb deletion in NRXN1 on chromosome 2 (bp 51017111-51136802) was validated

  3. Atypical hand-foot-genital syndrome and developmental delay due to de novo mutations in HOXA13 (show HOXA13 Proteins) and NRXN1

  4. The rare variants in NRXN1 were significantly associated with smoking status.

  5. NRXN1 has an affinity for binding to LRRTM2 (show LRRTM2 Proteins) in hippocampal synapses.

  6. heterozygous inactivation of NRXN1 directly impairs synaptic function in human neurons.

  7. Increasing expression of TGF-beta1 (show TGFB1 Proteins) protein, decreasing expressions of Ghrelin (show GHRL Proteins), Neurexin, and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal

  8. Results indicate that the neurexin and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 (show DISC1 Proteins) function, thus contributing to a better understanding of the pathology of schizophrenia.

  9. Study suggests a role of rare missense variants at NRXN1 and AKAP9 in schizophrenia susceptibility, probably related to alteration of the excitatory/inhibitory synaptic balance, deserving further investigation

  10. The phenotype found in the microdeletions of alpha exons of the NRXN1 gene is clearly distinguishable from the one found in the microdeletions of beta exons, with macrocephaly, epilepsy and mental retardation.

Cow (Bovine) Neurexin 1 (NRXN1) interaction partners

  1. The structure of neurexin 1alpha reveals features promoting a role as synaptic organizer

  2. The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function

  3. crystallographic analysis of the second LNS/LG domain from neurexin 1alpha

Mouse (Murine) Neurexin 1 (NRXN1) interaction partners

  1. Findings demonstrate that the heterozygous loss of alpha-neurexin I and alpha-neurexin II (show NRXN2 Proteins) in mice leads to phenotypes relevant to autism and schizophrenia

  2. Study shows that astrocyte-secreted hevin is a trans-synaptic linker that bridges presynaptic NRX1alpha with postsynaptic NL1B. This way, hevin organizes both pre- and postsynaptic specializations and aligns them across the synapse.

  3. Nlgn3 (show NLGN3 Proteins) and Nrxn1 are differentially expressed in cerebral cortex and hippocampus which might be responsible for alterations in synaptic plasticity during agine.

  4. Thus our data suggest that perinatal exposure to BPA (show DST Proteins) impairs spatial memory through upregulation of expression of synaptic proteins Nrxn1 and Nlgn3 (show NLGN3 Proteins) and increased dendritic spine density in cerebral cortex and hippocampus of postnatal male mice.

  5. Mutant neurexin-1beta expression in mouse adult brain leads to core autism symptoms.

  6. neurexin 1 interaction with multi-PDZ domain protein MUPP1

  7. Deletions within NRXN1 found in patients may be responsible for the impairments seen in social behaviours and Nrxn1alpha knockout mice are a useful model of human neurodevelopmental disorders.

  8. Nrxn1 and Nlgn (show NLGN4X Proteins) genes that may represent an important aspect of their function at synapses in health and disease

  9. Cross-species co-expression and protein interaction network analyses identify glycogen synthase kinase 3 beta (GSK3B) as one of the most consistent and conserved covariates of NRXN1.

  10. Parallel fiber protrusion triggered by neurexin signaling promotes bidirectional maturation of parallel fiber-Purkinje cell synapses by positive feedback.

Neurexin 1 (NRXN1) Protein Profile

Protein Summary

Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms\; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible.

Gene names and symbols associated with Neurexin 1 Proteins (NRXN1)

  • neurexin 1 (NRXN1)
  • Neurexin 1 (Nrx-1)
  • neurexin 1 (Nrx-1)
  • neurexin 1 (nrxn1)
  • neurexin 1 (Nrxn1)
  • neurexin I (Nrxn1)
  • 1700062G21Rik protein
  • 9330127H16Rik protein
  • A230068P09Rik protein
  • CG7050 protein
  • CT21808 protein
  • Dmel\\CG7050 protein
  • dnrx protein
  • dnrx-1 protein
  • GB13455 protein
  • GB18754 protein
  • Hs.22998 protein
  • mKIAA0578 protein
  • nrx protein
  • Nrx-1 protein
  • Nrx1 protein
  • NRXN1 protein
  • Nrxn1b protein
  • PTHSL2 protein
  • SCZD17 protein

Protein level used designations for Neurexin 1 Proteins (NRXN1)

CG7050-PA , CG7050-PB , CG7050-PC , CG7050-PD , CG7050-PE , CG7050-PF , CG7050-PG , CG7050-PH , Neurexin-1 , Neurexin-like , Nrx-1-PA , Nrx-1-PB , Nrx-1-PC , Nrx-1-PD , Nrx-1-PE , Nrx-1-PF , Nrx-1-PG , Nrx-1-PH , drosophila neurexin , neurexin , neurexin 1 , neurexin 1 alpha , neurexin 1 beta , neurexin-1-beta isoform alpha1 , neurexin-1-beta isoform alpha2 , neurexin I-like , neurexin-1-alpha-like , neurexin I-alpha , neurexin I-beta , neurexin-1-alpha , neurexin-1-beta , non-processed neurexin I-alpha , neurexin I , neurexin-1 , neurexin I alpha , alpha-latrotoxin receptor (calcium-dependent)

781054 Sus scrofa
42646 Drosophila melanogaster
459224 Pan troglodytes
619185 Macaca mulatta
724217 Apis mellifera
100052908 Equus caballus
100127647 Xenopus (Silurana) tropicalis
100349063 Oryctolagus cuniculus
100466581 Ailuropoda melanoleuca
100567183 Anolis carolinensis
60391 Rattus norvegicus
9378 Homo sapiens
474589 Canis lupus familiaris
281950 Bos taurus
395398 Gallus gallus
100622083 Sus scrofa
18189 Mus musculus
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