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Neuroligin 3 Proteins (NLGN3)

NLGN3 encodes a member of a family of neuronal cell surface proteins. Additionally we are shipping Neuroligin 3 Antibodies (97) and Neuroligin 3 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NLGN3 54413 Q9NZ94
NLGN3 245537 Q8BYM5
Rat NLGN3 NLGN3 171297 Q62889
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Top Neuroligin 3 Proteins at

Showing 8 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag Human Neuroligin 3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Macaca mulatta His tag   1 mg Log in to see 56 to 66 Days
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

NLGN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Mouse (Murine)

Top referenced Neuroligin 3 Proteins

  1. Human NLGN3 Protein expressed in Human Cells - ABIN2004032 : Irie, Hata, Takeuchi, Ichtchenko, Toyoda, Hirao, Takai, Rosahl, Südhof: Binding of neuroligins to PSD-95. in Science (New York, N.Y.) 1997 (PubMed)
    Show all 2 references for ABIN2004032

  2. Human NLGN3 Protein expressed in HEK-293 Cells - ABIN2181537 : Graf, Zhang, Jin, Linhoff, Craig: Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. in Cell 2004 (PubMed)
    Show all 2 references for ABIN2181537

  3. Human NLGN3 Protein expressed in Human - ABIN2727167 : Venkatesh, Johung, Caretti, Noll, Tang, Nagaraja, Gibson, Mount, Polepalli, Mitra, Woo, Malenka, Vogel, Bredel, Mallick, Monje: Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion. in Cell 2015 (PubMed)

More Proteins for Neuroligin 3 (NLGN3) Interaction Partners

Human Neuroligin 3 (NLGN3) interaction partners

  1. No statistically significant haplotypes have been found associated to autism in the NLGN3 after logistic regression and permutation analysis.

  2. The synaptic protein neuroligin-3 (NLGN3) was identified as the leading candidate mitogen, and soluble NLGN3 was sufficient and necessary to promote robust high-grade glioma cell proliferation.

  3. Our data provided a further evidence for the involvement of NLGN3 and NLGN4X (show NLGN4X Proteins) gene in the pathogenesis of autism in Chinese population.

  4. The present study explores, for the first time, the contribution of NLGN3 and NLGN4X (show NLGN4X Proteins) genetic variants in Greek patients with autistic disorder.

  5. Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.

  6. Neuroligins are adhesion proteins that bind to beta-neurexin (show NRXN1 Proteins) to form functional synapses.

  7. Data from studies using cross-linking reagents suggest that neuroligins form dimers, including homodimers and, most notably, neuroligin 1 (show NLGN1 Proteins)/3 heteromers; autism-associated neuroligin mutant (neuroligin 3 R471C) forms heterodimers with neuroligin 1 (show NLGN1 Proteins).

  8. study provides initial evidence that a common variant in NLGN3 gene may play a role in the etiology of ASDs among affected males in Chinese Han population.

  9. further characterization of the R451C mutation in NLGN3;role in protein folding

  10. report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 (show NLGN4X Proteins) in siblings with autism-spectrum disorders

Mouse (Murine) Neuroligin 3 (NLGN3) interaction partners

  1. Nlgn3 and Nrxn1 (show NRXN1 Proteins) are differentially expressed in cerebral cortex and hippocampus which might be responsible for alternations in synaptic plasticity during aging.

  2. These findings suggest that structural changes in the brain of NL-3 mice are induced by the mutation in the NL-3 gene

  3. Thus our data suggest that perinatal exposure to BPA (show DST Proteins) impairs spatial memory through upregulation of expression of synaptic proteins Nrxn1 (show NRXN1 Proteins) and Nlgn3 and increased dendritic spine density in cerebral cortex and hippocampus of postnatal male mice.

  4. Therefore, we sought to replicate our findings in the neuroligin-3 R451C point mutant knock-in mouse model (NL3R451C) in a different genetic background.

  5. We used MRI (show C7ORF49 Proteins) to image three genetic mouse models with single mutations implicated in autism: Neuroligin-3 R451C knock-in, Methyl-CpG binding protein-2 (MECP2 (show MECP2 Proteins)) 308-truncation and integrin beta3 homozygous knockout.

  6. Results indicate that autism spectrum disorders (ASD (show GUSB Proteins))-associated NL3 mutations commonly disrupt striatal circuits in a subregion-, cell-type-, and synapse-specific fashion and suggest that this disruption may shape repetitive and stereotypic behaviors associated with ASD (show GUSB Proteins).

  7. Neuroligin-3 R704C-mutant induced neurons exhibit a large and selective decrease in AMPA (show GRIA3 Proteins)-type glutamate (show GRIN1 Proteins) receptor-mediated synaptic transmission without changes in NMDA-type glutamate (show GRIN1 Proteins) receptor- or in GABAA (show GABRg1 Proteins) receptor-mediated synaptic transmission.

  8. Our data thus suggest that neuroligin-3 is specifically required for tonic endocannabinoid signaling

  9. in NL3(R451C) mutant mice, a single point mutation in a synaptic cell adhesion molecule (show CADM1 Proteins) causes context-dependent changes in synaptic transmission

  10. The NL-3 acts redundantly to maintain excitatory synapses and that synapse elimination caused by the absence of NL-3 is promoted by synaptic activity and mediated by a postsynaptic Ca(2 (show CA2 Proteins)+)/CaM (show Calm2 Proteins)-dependent signaling pathway.

Neuroligin 3 (NLGN3) Protein Profile

Protein Summary

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with Neuroligin 3 Proteins (NLGN3)

  • neuroligin 3 (Nlgn3)
  • neuroligin 3 (nlgn3)
  • neuroligin 3 (NLGN3)
  • neuroligin 3 (NLG-3)
  • A230085M13Rik protein
  • CCE-L1 protein
  • GB18290 protein
  • HNL3 protein
  • NL3 protein
  • NLGN3 protein
  • NV16744 protein
  • Nv1604741 protein

Protein level used designations for Neuroligin 3 Proteins (NLGN3)

neuroligin 3 , neuroligin-3 , neuroligin 3 isoform A1A2 , carboxylesterase clade L, member 3 , gliotactin homolog , neuroligin 3 protein , Neuroligin-3

409003 Apis mellifera
447240 Xenopus laevis
473660 Pan troglodytes
511251 Bos taurus
659852 Tribolium castaneum
770104 Gallus gallus
100121155 Nasonia vitripennis
100329188 Xenopus (Silurana) tropicalis
54413 Homo sapiens
491947 Canis lupus familiaris
245537 Mus musculus
171297 Rattus norvegicus
574216 Macaca mulatta
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