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NPY encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. Additionally we are shipping NPY Antibodies (166) and NPY Kits (69) and many more products for this protein.
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Neuropeptide Y mRNA content decreased 6 h after a meal, but increased to prefeeding levels by 24 h.
Our results provided clinical evidences for NPY participating in the bone healing process in a nonhypothalamic manner, most probably by directly promoting osteogenesis of mesenchymal stem cells.
In conclusion, the obtained results demonstrate the probable role of NPY SNPs in susceptibility to multiple sclerosis within the Iranian population.
Neuropeptide Y is the best dipeptidyl peptidase 4 (DPP4 (show DPP4 Proteins))-substrate in blood, being truncated by soluble and membrane DPP4 (show DPP4 Proteins), respectively. The decline of soluble DPP4 (show DPP4 Proteins) in acute depression could be reversed upon anti-depressive treatment.
study implicates NPY as a potential target in antihypertensive therapies for preeclampsia patients
NPY is efficiently cleaved by FAP indicating a potential function for FAP in neuropeptide regulation within liver and cancer biology.
NPY plays important roles in the pathogenesis and pathophysiology of pituitary adenomas, as shown in this clinical study.
NPY levels were higher in both obese and non-obese PCOS patients compared to healthy controls.
Authors observed that NPY levels were decreased in two (show ATXN3 Proteins)Machado-Joseph disease patients' cerebella.
Suggest IL-4 (show IL4 Proteins) as marker of allergic airway inflammation in asthma, and roles for adiponectin (show ADIPOQ Proteins) and neuropeptide Y in neurohormonal signaling.
This study suggests that NPY rs16147 T and rs16139 C minor alleles are associated with increased risk, whereas the minor allele T of the rs5574 is associated with a reduced risk of obesity.
Stress may be associated with elevated peripheral neuropeptide Y level, which was observed to be associated with exacerbated airway inflammation in asthmatic mice.
that preconditioning of mice with intermittent mild hypobaric hypoxia induces anxiolytic- and antidepressant-like effects which are accompanied by up-regulation of NPY which may suggest its mechanistic role
confirms the critical role of Y2 signalling to control neuropeptide Y and associated pro-opiomelanocortin (show POMC Proteins) expression in the arcuate nuclei
Neuropeptide Y (NPY) has been shown to be important in the modulation of anxiety.
Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP (show AGRP Proteins)/NPY neurons in mice.
NPY might be involved in the pathogenesis of METH (show MTRR Proteins)-induced atherogenic effects through NPY Y1 receptor pathway in ApoE (show APOE Proteins) knockout mice
NPY deficiency leads to reduced orexigenic stimulation and water diffusion parameters
NPY suppresses cAMP activation of brown-like adipocytes via down-regulation o brown fat-relevant gene expression and mitochondrial function.
Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp (show AGRP Proteins)) and neuropeptide Y (Npy) gene expression similarly in Ghrelin (show GHRL Proteins)+/+, Ghrelin (show GHRL Proteins)-/-, ghrelin receptor Ghsr (show GHSR Proteins)+/+, and Ghsr (show GHSR Proteins)-/- mice.
These data demonstrate a clear role for neuropeptide Y as a negative regulator of monocyte recruitment into the central nervous system and provide a new mechanism for suppression of retrovirus-induced neurological disease.
Results show that the PP-fold is not important for recognition of peptide YY or neuropeptide Y at Y receptors.
NPY has a positive inotropic effect in isolated rat cardiac myocytes, which involves increase in Ca2 (show CA2 Proteins)+ release after activation of Y1 NPY receptor
High dietary copper appears to increase feed intake and promote weight gain by enhancing NPY concentration and NPY mRNA expression level in the hypothalamus of pigs.
Neuropeptide Y was released from the lung tissue of brain-dead pigs, and its concentration was related to the extent of neurogenic pulmonary edema
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (show LEP Proteins)-NPY and insulin (show INS Proteins) signaling pathways.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin (show LEP Proteins) and hypothalamic neuropeptide Y (NPY) release.
There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin (show LEP Proteins), and IGF-1 (show IGF1 Proteins) genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.
The NPY SNP (NPY1) was associated with the prevalence of the animal being in calf 100 d after calving and 305-d milk yield in the first lactation.
NPY tended to increase serum growth hormone (show GH1 Proteins), which appeared to be a consequence of increased pulse amplitude. Infusion of NPY also increased CSF (show CSF2 Proteins) growth hormone-releasing hormone (show GHRH Proteins).
Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin (show GAL Proteins), somatostatin (show SST Proteins), NPY, and VIP (show Vip Proteins).
The present investigation provides results of increased vasocontractile effect of NOR and decreased enhancing effect of NPY on NOR vasoconstriction in the rabbit facial artery after carotid occlusion that is related to altered endothelium function
NPY acts as an orexigenic factor in the zebrafish.
Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties.(
Developmental expression of zYb and zYc receptors suggests a role for neuropeptide Y (NPY) in organogenesis.
In this study described the the lateral line presence of NPY-like immunoreactivity (IR) in of the Antarctic nototheniod fish. Differences in size and cellular composition between the two neuromasts were presen NPY immunoreactivity.
A 2-day fast increased NPY gene expression in the supraoptic nucleus and paraventricular nucleus.
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
, neuropeptide Ya
, prepro-neuropeptide Y
, pro-neuropeptide Y
, pro-neuropeptide Y preproprotein
, neuropeptide Yb
, pre-pro hormone
, preproneuropeptide Y, preproNPY