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Nuclear Factor (erythroid-Derived 2)-Like 2 Proteins (NFE2L2)

NFE2L2 encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. Additionally we are shipping NRF2 Antibodies (166) and NRF2 Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NFE2L2 4780 Q16236
NFE2L2 18024 Q60795
NFE2L2 83619 O54968
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Top NRF2 Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

NFE2L2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) Interaction Partners

Zebrafish Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Bach1 (show BACH1 Proteins) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Proteins) inhibition based on its level in each tissue.

  2. The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.

  3. The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.

  4. oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.

  5. results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles

  6. compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds

  7. Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.

  8. mutation of either residual cysteine residue in Keap1a (show KEAP1 Proteins) and Keap1b disrupted the ability of Keap1 (show KEAP1 Proteins) to repress Nrf2, indicating that the presence of either Cys (show DNAJC5 Proteins)-273 or Cys (show DNAJC5 Proteins)-288 is sufficient for fish Keap1 (show KEAP1 Proteins) molecules to fully function

  9. study reports that the Keap1 (show KEAP1 Proteins)-Nrf2 system comprises discrete sensor sites, including the Keap1 (show KEAP1 Proteins) cysteines Cys (show DNAJC5 Proteins)-151 and Cys (show DNAJC5 Proteins)-273, for a variety of Nrf2-activating compounds

  10. findings demonstrate that antioxidant responses are a component of polycyclic aromatic hydrocarbon (PAH)synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development

Cow (Bovine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Proteins) within these cells.

  2. the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.

  3. investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Proteins) gene expression in aortic endothelial cells by advanced glycation end products

Pig (Porcine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.

Human Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. expression of Nrf2 (show GABPA Proteins)-Keap1 (show KEAP1 Proteins) is abnormal in osteosarcoma tissue and shows significant clinical relevance for determining the prognosis of osteosarcoma

  2. that targeted repression of Keap1 and activation of Nrf2 pathway, in part, underlies the protective effects of miR-7 against 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in SH-SY5Y

  3. This review focuses on the Nrf2 (show GABPA Proteins)/HO-1 (show HMOX1 Proteins) stress response mechanism as a promising target for anticancer treatment which is able to overcome resistance to therapies.

  4. NFE2L2-mediated gene expression reflects lung cancer severity and progression. [meta-analysis]

  5. review the recent findings on the roles of NRF2 (show GABPA Proteins) in maintenance of the redox state and multidrug resistance in CSCs, focusing on how NRF2 (show GABPA Proteins)-mediated ROS (show ROS1 Proteins) modulation influences the growth and resistance of CSCs.

  6. findings suggest that Nrf2 (show GABPA Proteins) pathway and autophagy have a negative interaction with each other upon ROS (show ROS1 Proteins) stimulation.

  7. The pathogenic H5N1 and H7N9 influenza virus variants cause more severe deregulation of NRF2 (show GABPA Proteins) and fibronectin (show FN1 Proteins) in host epithelial cells than the less pathogenic H1N1 variant.

  8. CYP2C8 (show CYP2C8 Proteins)-derived epoxyeicosatrienoic acids prevented TNF-alpha (show TNF Proteins)-induced HUVECs apoptosis via inhibition of oxidative stress associated with the Nrf2 (show GABPA Proteins) signaling.

  9. The results suggested that Nrf2 (show GABPA Proteins)/ARE pathway is involved in mild to moderate PQ-induced oxidative stress which is evident from dampened Nrf2 (show GABPA Proteins) activity and low expression of antioxidant genes in PQ induced oxidative damage.

  10. Nrf2 (show GABPA Proteins) binds directly to upstream regions of these pluripotency genes to promote their expression and repress neuroectoderm derivation.Nrf2 suppression was sufficient to rescue poorly neurogenic induced pluripotent stem cell lines.

Mouse (Murine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Nrf2 expression increases in the lung and BALF of ALI mice, suggesting that Nrf2 is involved in the inflammation during acute lung injury

  2. The Interplay Between Peroxiredoxin-2 (show PRDX2 Proteins) and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in beta-Thalassemic Erythropoiesis

  3. load of mice to +9 Gz hypergravity causes AMPKalpha (show GRK4 Proteins) repression with liver injury, which may be overcome by multiple loads to hypergravity as mediated by Nrf2

  4. Irradiation inhibits osteoblast differentiation and mineralization of MC3T3-E1 cells through the oxidative stress-mediated activation of Nrf2/HO-1 (show HMOX1 Proteins) pathway.

  5. low 4-Hydroxy-2-nonenal (HNE (show ELANE Proteins)) doses activate Nrf2 in cardiomyocytes and provide the first evidence of Nrf2 binding to the Ucp3 promoter in response to HNE (show ELANE Proteins), leading to increased protein expression

  6. Mechanistic interpretation for this GSTP (show GSTP1 Proteins)-dependent effect may include a direct and redox-sensitive interaction of GSTP (show GSTP1 Proteins) with Nrf2 protein

  7. Results demonstrate Nrf2 regulates the generation, survival, and suppressive potency of myeloid-derived suppressor cells (MDSC), and that a feedback homeostatic mechanism maintains a steady-state level of circulating MDSC in tumor-bearing individuals.

  8. H2 suppresses ROS (show ROS1 Proteins) accumulation by upregulating Nrf2 signaling, which may contribute to its inhibitory effect on macrophage apoptosis

  9. Cacul1 regulates the antioxidant response by stabilizing Nrf2.

  10. results show that the anti-oxidative and anti-inflammatory effects of digitoflavone are mediated by Nrf2 activation and that digitoflavone can be used therapeutically to improve metabolic disorders and relieve renal damage induced by diabetes.

NRF2 (NFE2L2) Protein Profile

Protein Summary

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NFE2L2

  • nuclear factor (erythroid-derived 2)-like 2a (nfe2l2a)
  • nuclear factor (erythroid-derived 2)-like 2 (nfe2l2)
  • nuclear factor (erythroid-derived 2)-like 2 (NFE2L2)
  • nuclear factor, erythroid 2-like 2 (NFE2L2)
  • nuclear factor, erythroid derived 2, like 2 (Nfe2l2)
  • AI194320 protein
  • NF-E2R2 protein
  • nfe2l2 protein
  • NRF2 protein
  • wu:fc15g09 protein
  • wu:fj67e03 protein

Protein level used designations for NFE2L2

Nrf2a , nuclear factor (erythroid-derived 2)-like 2 , nuclear factor erythroid 2-related factor 2 , ECH , NF-E2-related factor 2 , NFE2-related factor 2 , nuclear factor, erythroid derived 2, like 2 , HEBP1 , nuclear factor erythroid-derived 2-like 2 , nrf2 , nuclear factor erythroid 2-like 2

360149 Danio rerio
444736 Xenopus laevis
396014 Gallus gallus
478813 Canis lupus familiaris
497024 Bos taurus
100516343 Sus scrofa
4780 Homo sapiens
18024 Mus musculus
83619 Rattus norvegicus
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