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Nuclear Factor (erythroid-Derived 2)-Like 2 Proteins (NFE2L2)

NFE2L2 encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. Additionally we are shipping NRF2 Antibodies (167) and NRF2 Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NFE2L2 4780 Q16236
NFE2L2 18024 Q60795
NFE2L2 83619 O54968
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Top NRF2 Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

NFE2L2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) Interaction Partners

Zebrafish Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Bach1 (show BACH1 Proteins) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Proteins) inhibition based on its level in each tissue.

  2. The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.

  3. The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.

  4. oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.

  5. results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles

  6. compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds

  7. Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.

  8. mutation of either residual cysteine residue in Keap1a (show KEAP1 Proteins) and Keap1b disrupted the ability of Keap1 (show KEAP1 Proteins) to repress Nrf2, indicating that the presence of either Cys (show DNAJC5 Proteins)-273 or Cys (show DNAJC5 Proteins)-288 is sufficient for fish Keap1 (show KEAP1 Proteins) molecules to fully function

  9. study reports that the Keap1 (show KEAP1 Proteins)-Nrf2 system comprises discrete sensor sites, including the Keap1 (show KEAP1 Proteins) cysteines Cys (show DNAJC5 Proteins)-151 and Cys (show DNAJC5 Proteins)-273, for a variety of Nrf2-activating compounds

  10. findings demonstrate that antioxidant responses are a component of polycyclic aromatic hydrocarbon (PAH)synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development

Cow (Bovine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Proteins) within these cells.

  2. the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.

  3. investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Proteins) gene expression in aortic endothelial cells by advanced glycation end products

Pig (Porcine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.

Human Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Data suggest gene expression in vascular endothelium can be altered by dietary factors; here, aged garlic extract induces expression of HMOX1 (heme oxygenase-1 (show HMOX1 Proteins)) and GCLM (glutamate-cysteine ligase modifier subunit (show GCLM Proteins)) via activation of NRF2 (show GABPA Proteins)-ARE signaling.

  2. Studies indicate a negative impact of nuclear factor erythroid 2-like factor 2 (Nrf2 (show GABPA Proteins)) signal on non-small cell lung cancer (NSCLC) patients' survival.

  3. Clopidogrel diminishes TNFalpha (show TNF Proteins)-stimulated VCAM-1 (show VCAM1 Proteins) expression at least in part via HO-1 (show HMOX1 Proteins) induction and CaMKKbeta/AMPK (show PRKAA1 Proteins)/Nrf2 (show GABPA Proteins) pathway in endothelial cells.

  4. SIRT6 (show SIRT6 Proteins) in a protein complex with both nuclear factor erythroid 2-related factor 2 (NRF2) and RNA polymerase II.

  5. nuclear factor kappa B (NF-kappaB (show NFKB1 Proteins)), nuclear E2-related factor 2 (Nrf2 (show GABPA Proteins)), glycolytic, and p53 (show TP53 Proteins) pathways during neuronal differentiation, were evaluated.

  6. NRF2 (show GABPA Proteins) regulates both HER2 (show ERBB2 Proteins) and HER3 (show ERBB3 Proteins) receptors to influence cellular responses to HER2 (show ERBB2 Proteins) targeting.

  7. Oxidative stress-responsive transcription factor NRF2 (show GABPA Proteins) is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3 (show FMO3 Proteins)) gene expression in HepG2 cells

  8. Studies show NRF2 (show GABPA Proteins) as an important player in the cellular antioxidant response and other functions in a cell-type specific manner. Its expression is under the control of microRNA. [review]

  9. Studies demonstrate that Keap1 (show KEAP1 Proteins)-Nrf2 (show GABPA Proteins) pathway is important to orchestrate an elaborate genetic program that enhances the intrinsic cytoprotective functions, including drug metabolizing, antioxidant and antiinflammatory networks. [review]

  10. Studies suggest a functional cross-talk between Nrf2 (show GABPA Proteins) and NF-kappaB (show NFKB1 Proteins) pathways. The absence of Nrf2 (show GABPA Proteins) can exacerbate NF-kappaB (show NFKB1 Proteins) activity, whereas NF-kappaB (show NFKB1 Proteins) can modulate Nrf2 (show GABPA Proteins) transcription and activity, both having effects on the target gene expression. [review]

Mouse (Murine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2-mediated control of SLPI (show SLPI Proteins) and syndecan 4 (show SDC4 Proteins).

  2. loss of Nrf2 or NF-kappaB (show NFKB1 Proteins)/RelA (show NFkBP65 Proteins) altered the expression of different genes, and the combination of these alterations likely affects liver homeostasis in the double mutant mice

  3. Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a (show ATP2A2 Proteins), and preserved endothelial function.

  4. Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression.

  5. These results indicated that the Nrf2-ARE system exhibited a protective role in Pb-induced neurotoxicity, providing potential therapeutic strategies for the prevention and treatment of Pb-related diseases.

  6. These results indicate that sargaquinoic acid(SQA) inhibits the lipopolysaccharide-induced expression of inflammatory mediators as well as up-regulation of the Nrf2/HO-1 (show HMOX1 Proteins) pathway.

  7. Nrf2-/- mice have accelerated ovarian aging and increased sensitivity to the ovarian toxicity of benzo[a]pyrene.

  8. Nrf2 expression increases in the lung and BALF of ALI mice, suggesting that Nrf2 is involved in the inflammation during acute lung injury

  9. The Interplay Between Peroxiredoxin-2 (show PRDX2 Proteins) and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in beta-Thalassemic Erythropoiesis

  10. load of mice to +9 Gz hypergravity causes AMPKalpha (show GRK4 Proteins) repression with liver injury, which may be overcome by multiple loads to hypergravity as mediated by Nrf2

NRF2 (NFE2L2) Protein Profile

Protein Summary

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NFE2L2

  • nuclear factor (erythroid-derived 2)-like 2a (nfe2l2a)
  • nuclear factor (erythroid-derived 2)-like 2 (nfe2l2)
  • nuclear factor (erythroid-derived 2)-like 2 (NFE2L2)
  • nuclear factor, erythroid 2-like 2 (NFE2L2)
  • nuclear factor, erythroid derived 2, like 2 (Nfe2l2)
  • AI194320 protein
  • NF-E2R2 protein
  • nfe2l2 protein
  • NRF2 protein
  • wu:fc15g09 protein
  • wu:fj67e03 protein

Protein level used designations for NFE2L2

Nrf2a , nuclear factor (erythroid-derived 2)-like 2 , nuclear factor erythroid 2-related factor 2 , ECH , NF-E2-related factor 2 , NFE2-related factor 2 , nuclear factor, erythroid derived 2, like 2 , HEBP1 , nuclear factor erythroid-derived 2-like 2 , nrf2 , nuclear factor erythroid 2-like 2

360149 Danio rerio
444736 Xenopus laevis
396014 Gallus gallus
478813 Canis lupus familiaris
497024 Bos taurus
100516343 Sus scrofa
4780 Homo sapiens
18024 Mus musculus
83619 Rattus norvegicus
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