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Nuclear Factor (erythroid-Derived 2)-Like 2 Proteins (NFE2L2)

NFE2L2 encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. Additionally we are shipping NRF2 Antibodies (171) and NRF2 Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NFE2L2 4780 Q16236
NFE2L2 18024 Q60795
NFE2L2 83619 O54968
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Top NRF2 Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

NFE2L2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) Interaction Partners

Zebrafish Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Bach1 (show BACH1 Proteins) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Proteins) inhibition based on its level in each tissue.

  2. The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.

  3. The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.

  4. oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.

  5. results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles

  6. compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds

  7. Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.

  8. mutation of either residual cysteine residue in Keap1a (show KEAP1 Proteins) and Keap1b disrupted the ability of Keap1 (show KEAP1 Proteins) to repress Nrf2, indicating that the presence of either Cys (show DNAJC5 Proteins)-273 or Cys (show DNAJC5 Proteins)-288 is sufficient for fish Keap1 (show KEAP1 Proteins) molecules to fully function

  9. study reports that the Keap1 (show KEAP1 Proteins)-Nrf2 system comprises discrete sensor sites, including the Keap1 (show KEAP1 Proteins) cysteines Cys (show DNAJC5 Proteins)-151 and Cys (show DNAJC5 Proteins)-273, for a variety of Nrf2-activating compounds

  10. findings demonstrate that antioxidant responses are a component of polycyclic aromatic hydrocarbon (PAH)synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development

Cow (Bovine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Proteins) within these cells.

  2. the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.

  3. investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Proteins) gene expression in aortic endothelial cells by advanced glycation end products

Pig (Porcine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.

Human Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Both Nrf2 (show GABPA Proteins) and NF-kappaB (show NFKB1 Proteins) signaling may be pivotal in the regulation of drug-induced liver injury. NF-kappaB (show NFKB1 Proteins)-inhibiting effects that coincide with a strong Nrf2 (show GABPA Proteins) stress response likely sensitize liver cells to pro-apoptotic signaling cascades induced by intrinsic cytotoxic pro-inflammatory cytokines.

  2. A marked (show GABPA Proteins) increase in Nrf2 expression was detected in the leukocytes obtained from the Hemorrhagic shock patients, which indicates a correlation between Nrf (show MPO Proteins)2 expression and the development of Hemorrhagic shock.

  3. Glioma patients with high Nrf2 (show GABPA Proteins) brain expression had shorter overall survival than those with low levels.

  4. stress. Our combined data revealed a protective role of miR (show MLXIP Proteins)-214 signaling in erythroid cells against oxidative stress, and also shed new light on Nrf2 (show GABPA Proteins)-mediated cytoprotective machinery.

  5. TGF-beta (show TGFB1 Proteins) and hypoxia/reoxygenation promoted tumor progression and radioresistance of A549 cells through reactive oxygen species-mediated activation of Nrf2 (show GABPA Proteins) and EGFR (show EGFR Proteins).

  6. Inhibition of NRF2 (show GABPA Proteins) by KEAP1 (show KEAP1 Proteins) overexpression compromises metabolic reprogramming of fibroblasts and results in reduced efficiency of induced pluripotent stem cells colony formation.

  7. Phycocyanin prevented mitochondrial-dependent apoptosis in methylglyoxal induced INS-1 (show FOXM1 Proteins) cells and the effect was associated with Nrf2 (show GABPA Proteins) activation.

  8. Results suggest that NRF2 (show GABPA Proteins) plays an important role in regulating p53 (show TP53 Proteins) and SIRT1 (show SIRT1 Proteins) to maintain MSC (show MSC Proteins) stemness.

  9. Nrf2 (show GABPA Proteins) being elevated in early precursor lesions counteracts the growth inhibiting function of TGF-beta1 (show TGFB1 Proteins) already in benign and premalignant pancreatic ductal epithelial cells.

  10. antiangiogenic and anti-inflammatory activities of Hericium erinaceus may contribute to its anticancer property through inhibition of TNF-alpha (show TNF Proteins) and modulation of MMP-9 (show MMP9 Proteins)/NF-kappaB (show NFKB1 Proteins) and Nrf2 (show GABPA Proteins)-antioxidant signaling pathways

Mouse (Murine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Nrf2 deficiency increased susceptibility to oxidative stress-induced (show SQSTM1 Proteins) small intestinal carcinogenesis in mice

  2. Is closely associated with upregulation of the Ref1 (show THOC4 Proteins)/Nrf2 signalling pathway.

  3. SIRT1 (show SIRT1 Proteins) promoted the stability of NRF2 by regulating the deacetylation and activation of the NRF2/ARE antioxidant pathway.

  4. The Nrf2-KO mice exhibited more severe lung and liver injury following hemorrhagic shock as evidenced by increased tissue damage, increased myeloperoxidase (show MPO Proteins) activity and the increased production of pro-inflammatory cytokines. Additionally, Nrf2 deficiency augmented cytokine production induced by the exposure of peritoneal mouse macrophages to lipopolysaccharide following hemorrhagic shock.

  5. high NRF2 activity is advantageous for cochlear protection from noise-induced injury, and NRF2 is a promising target for NIHL prevention.

  6. These results suggest for the first time that FF prevents the development of diabetic nephropathy via up-regulating FGF21 (show FGF21 Proteins) and stimulating PI3K/Akt (show AKT1 Proteins)/GSK-3beta/Fyn (show FYN Proteins)-mediated activation of the Nrf2 pathway.

  7. Our results show that epicatechin protects the TBI (show TBPL1 Proteins) brain by activating the Nrf2 pathway, inhibiting heme oxygenase-1 (show HMOX1 Proteins) protein expression, and reducing iron deposition The latter two effects could represent an Nrf2-independent mechanism in this model of TBI (show TBPL1 Proteins)

  8. These results provide a new mechanism by which LXA4 inhibits LPS (show TLR4 Proteins)-induced ALI through Nrf2-mediated E-cadherin (show CDH1 Proteins) expression

  9. Caffeic acid induces Nrf2 activation by decreasing the expression of its inhibitor protein Keap1 (show KEAP1 Proteins) and blocking the binding of Nrf2 with Keap1 (show KEAP1 Proteins).

  10. Our observations that oral DMF treatment promoted immune modulation and provided equal clinical benefit in acute EAE in Nrf2(-/-) and WT mice, suggest that the antiinflammatory activity of DMF in treatment of MS patients may occur through alternative pathways, independent of Nrf2.

NRF2 (NFE2L2) Protein Profile

Protein Summary

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NFE2L2

  • nuclear factor (erythroid-derived 2)-like 2a (nfe2l2a)
  • nuclear factor (erythroid-derived 2)-like 2 (nfe2l2)
  • nuclear factor (erythroid-derived 2)-like 2 (NFE2L2)
  • nuclear factor, erythroid 2-like 2 (NFE2L2)
  • nuclear factor, erythroid derived 2, like 2 (Nfe2l2)
  • AI194320 protein
  • NF-E2R2 protein
  • nfe2l2 protein
  • NRF2 protein
  • wu:fc15g09 protein
  • wu:fj67e03 protein

Protein level used designations for NFE2L2

Nrf2a , nuclear factor (erythroid-derived 2)-like 2 , nuclear factor erythroid 2-related factor 2 , ECH , NF-E2-related factor 2 , NFE2-related factor 2 , nuclear factor, erythroid derived 2, like 2 , HEBP1 , nuclear factor erythroid-derived 2-like 2 , nrf2 , nuclear factor erythroid 2-like 2

360149 Danio rerio
444736 Xenopus laevis
396014 Gallus gallus
478813 Canis lupus familiaris
497024 Bos taurus
100516343 Sus scrofa
4780 Homo sapiens
18024 Mus musculus
83619 Rattus norvegicus
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