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anti-Nucleoside Phosphorylase (NP) Antibodies

NP encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. Additionally we are shipping Nucleoside Phosphorylase Kits (20) and Nucleoside Phosphorylase Proteins (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NP 290029  
NP 4860 P00491
NP 18950 P23492
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Top anti-Nucleoside Phosphorylase Antibodies at antibodies-online.com

Showing 10 out of 52 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IP, ELISA, WB 100 μg Log in to see 16 Days
$273.90
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$595.83
Details
Human Mouse Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$625.17
Details
Human Sheep Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB   50 μL Log in to see 8 to 10 Days
$390.50
Details
Cow Rabbit Biotin IF, IHC, ELISA, WB   1000 μL Log in to see 8 to 10 Days
$522.50
Details
Chemical Rabbit Biotin ELISA   100 μg Log in to see 8 to 10 Days
$566.50
Details
Chemical Rabbit FITC WB   100 μg Log in to see 8 to 10 Days
$625.17
Details
Cow Rabbit Biotin IF, ELISA, WB   1 mL Log in to see 5 to 7 Days
$339.82
Details

NP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus) , , ,
,
Human , , , ,
, , , ,
Mouse (Murine) , , ,
,

More Antibodies against Nucleoside Phosphorylase Interaction Partners

Cow (Bovine) Nucleoside Phosphorylase (NP) interaction partners

  1. the biological role of packing of the PNP monomers into a trimeric structure

  2. crystal structure complexed with analogs of the inhibitor 2-diaminopurine aglycone (purine nucleoside phosphorylase)

  3. PNP purine nucleoside phosphorylase was crystallized in space group P2(1)2(1)2(1) in the presence of (S)-PMPDAP and phosphate, and the resulting structure of the binary PNP/(S)-PMPDAP complex was refined at 2.05A resolution.

  4. alf (show GTF2A1L Antibodies) spleen enzyme is a homotrimer and previous suggestions for dissociation of this enzyme into more active monomers, upon dilution of the enzyme or addition of phosphate, are incorrect.

  5. PCR amplification of the calf phosphorylase from the calf spleen library, cloning, overexpression of the recombinant PNP, its enzymatic activity and interactions with typical ligands of mammalian wild type PNP are described.

  6. The transition-state structure of triple mutant PNP is altered as a consequence of the amino acids in the second sphere from the catalytic site.

Human Nucleoside Phosphorylase (NP) interaction partners

  1. the binding mechanism of a transition state analogue (DADMe-immucillin-H) to the purine nucleoside phosphorylase (PNP) enzyme, is reported.

  2. Data show that [15N, 2H]His8-purine nucleoside phosphorylase (PNP) had reduced catalytic site chemistry larger than proportional to the enzymatic mass difference.

  3. Study of genetic heterogeneity in systemic lupus erythematosus, the top associations in European ancestry were protein kinase (show CDK7 Antibodies), cyclic GMP (show NT5C2 Antibodies)-dependent, type I (PRKG1 (show PRKG1 Antibodies)) rs7897633 (P(Meta) = 2.75 x 10(-8)) and purine nucleoside phosphorylase (PNP) rs1049564 (P(Meta) = 1.24 x 10(-7)).

  4. Human small intestine is a key site for ribavirin phosphorolysis and that PNP is primarily involved in the metabolism.

  5. Complete lack of PNP triggers accumulation of deoxyguanosine, thereby disrupting B-cell development, the consequence of which is more profound with time, as was found in the older sister.

  6. Biochemical and genetic data on a cohort of seven patients from six families identified as PNPase (show PNPT1 Antibodies) deficient, is reported.

  7. This study for the first time describes elevated levels of alpha synuclein (show SNCA Antibodies) in pancreatic adenocarcinoma as well as highlights the potential of evaluating NP protein expression.

  8. investigation of catalytic mechanisms involved in catalysis by PNP: transition states in arsenolysis and phosphorolysis

  9. PNP operating at maximum catalytic potential permits more rapid peptide amide deuterium exchange and greater conformational flexibility of water-peptide bond exchange rate than in either of the complexes with transition state analogues.

  10. The optimum pH for PNP from human erythrocytes with xanthosine and xanthine is in the range 5-6, whereas those with guanosine, guanine, inosine & hypoxanthine are in the range 7-8. Possible PNP binding modes of Xan and Xao by mammalian PNPs are proposed.

Mouse (Murine) Nucleoside Phosphorylase (NP) interaction partners

  1. PNP deficiency causes cerebellar abnormalities, including Purkinje cell damage and progressive motor deficits.

  2. PNP is important for the survival of DP thymocytes. Accumulation of dGuo in cases of PNP deficiency leads to mitochondria-initiated apoptosis of DP thymocytes, which can be prevented by restoring PNP activity in the cells.

Nucleoside Phosphorylase (NP) Antigen Profile

Protein Summary

This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.

Gene names and symbols associated with NP

  • purine nucleoside phosphorylase 5a (pnp5a) antibody
  • diacylglycerol kinase, eta (DGKH) antibody
  • purine nucleoside phosphorylase (Pnp) antibody
  • purine nucleoside phosphorylase (PNP) antibody
  • purine-nucleoside phosphorylase (Pnp) antibody
  • AL024301 antibody
  • AU015798 antibody
  • fc27g06 antibody
  • NP antibody
  • Np-1 antibody
  • Np-2 antibody
  • Pnp1 antibody
  • PRO1837 antibody
  • PUNP antibody
  • wu:fc27g06 antibody
  • wu:fd51h11 antibody
  • zgc:77008 antibody

Protein level used designations for NP

inosine phosphorylase , inosine-guanosine phosphorylase , nucleoside phosphorylase , purine-nucleoside:orthophosphate ribosyltransferase , purine nucleoside phosphorylase , purine-nucleoside phosphorylase 1

GENE ID SPECIES
791647 Danio rerio
537533 Bos taurus
290029 Rattus norvegicus
4860 Homo sapiens
493724 Bos taurus
475393 Canis lupus familiaris
769958 Gallus gallus
100718329 Cavia porcellus
100157138 Sus scrofa
18950 Mus musculus
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