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ODC1 encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. Additionally we are shipping Ornithine Decarboxylase 1 Antibodies (213) and Ornithine Decarboxylase 1 Kits (35) and many more products for this protein.
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molecular cloning of species-specific enzyme and its antizyme-mediated degradation
mechanistic study of the molecular interactions between antizyme inhibitor and its interacting proteins CCND1 (show CCND1 Proteins) and ornithine decarboxylase
We earlier presented evidence for a physical interaction between ODC and SPR (show SPR Proteins) and we showed that RNAi-mediated knockdown of SPR (show SPR Proteins) expression significantly reduced native ODC enzyme activity and impeded Neuroblastoma (show ARHGEF16 Proteins) cell proliferation.
Bag-1 (show BAG1 Proteins) indirectly affects cell survival through c-Myc (show MYC Proteins) activated signalling that causes elevation of ornithine decarboxylase levels, leading to an increase of the polyamine content.
High ODC expression is associated with Medulloblastoma.
Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN).
Data suggest that down-regulation of ODC (using siRNA or pharmacologic inhibitor) in bone marrow-derived mesenchymal stem cells results in reduced intracellular polyamines (putrescine, spermidine, and spermine) and enhanced osteogenesis.
tumor ornithine decarboxylase level heterogeneity increased with increasing tumor malignancy
The results suggested that the ODC gene might act as a prognostic factor for breast cancer and it could be a promising therapeutic target.
BTF3 (show BTF3 Proteins), HINT1 (show HINT1 Proteins), NDRG1 (show NDRG1 Proteins) and ODC1 protein over-expression in human prostate cancer tissue
Akt (show AKT1 Proteins) activation by ODC+COX-2 over-expression.
Translation of ODC is therefore integral to cytoplasmic maturation, protecting metaphase II oocytes from reactive oxygen species-induced apoptosis.
the Myc (show MYC Proteins)-ODC axis plays a critical role in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 (show JAK2 Proteins) V617F mutant
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
Androgens act via the AR to upregulate Odc1 in skeletal muscle myoblasts, and Odc1 promotes myoblast proliferation and delays differentiation.
the immunosuppression promoted by increased epidermal ODC is mediated by a reduction in cytokine levels, which suppresses dendritic cell migration and reduces immune cell infiltration to the site of hapten application
HuR (show ELAVL1 Proteins) plays a causative role in ODC up-regulation during nonmelanoma skin cancer development by binding to and stabilizing the ODC transcript.
Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation
In B16-F1 cells HGF (show HGF Proteins) increased AP-1 (show JUN Proteins) activity and the mRNA expression of various AP-1 (show JUN Proteins) subunits. HGF (show HGF Proteins)-induced transcription of mouse ODC was largely due to triggering of AP-1 (show JUN Proteins) pathway.
cell constituents required for mODC degradation are conserved between animals and fungi, and that both mammalian and fungal ODC are subject to proteasome-mediated proteolysis by ubiquitin-independent mechanisms
The role of ODC in the Citrobacter rodentium model of colitis was studied. ODC was induced in the colon during the infection. Inhibition of ODC exacerbated the colitis.
elevated ODC values found in the ovary of immature and adult mice play a relevant function in ovarian physiology
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.
ornithine decarboxylase 1
, ornithine decarboxylase
, group IV decarboxylase
, Ornithine decarboxylase
, Ornitine decarboxylase
, ODC 1