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PTK2 Protein tyrosine Kinase 2 (PTK2) ELISA Kits

PTK2 encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Additionally we are shipping FAK Antibodies (652) and FAK Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PTK2 5747 Q05397
PTK2 25614 O35346
PTK2 14083 P34152
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Top FAK ELISA Kits at

Showing 6 out of 28 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Rat 11.75 pg/ml 47-3000 pg/mL 96 Tests Log in to see 11 to 13 Days
Mouse 15.63 pg/ml 4000-62.5 pg/mL 96 Tests Log in to see 11 to 13 Days
Chicken 11.72 pg/ml 46.88-3000 pg/mL 96 Tests Log in to see 11 to 13 Days
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More ELISA Kits for FAK Interaction Partners

Human PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. In human colon cancer cells, Akt1 (show AKT1 ELISA Kits) binds focal adhesion kinase via the Akt1 kinase (show AKT1 ELISA Kits) domain independently of the pleckstrin (show PLEK ELISA Kits) homology domain

  2. FAK enhances glycolysis and decreases mitochondrial respiration and increases key glycolytic proteins. Active/tyrosine-phosphorylated FAK directly binds to PKM2 and promotes PKM2-mediated glycolysis.

  3. Our findings suggest that the targets of FAK play a key role in metastasis

  4. Data suggest that, in colonic/prostatic neoplasm cells, increased expression of NDRG1 decreases activating phosphorylation of FAK and paxillin; silencing/inhibition of NDRG1 results in opposite effect and inhibits neoplasm cell migration/adhesion.

  5. Collectively, our data demonstrate that DCMF induces cell migration and promotes wound healing through activation of Src (show SRC ELISA Kits)/FAK, ERK (show EPHB2 ELISA Kits), AKT (show AKT1 ELISA Kits), and p38 MAPK (show MAPK14 ELISA Kits) signaling.

  6. These results suggest that ITCs could be potential agents for the prevention of C6 glioma cell migration and invasion by decreasing FAK/JNK (show MAPK8 ELISA Kits)-mediated MMP-9 (show MMP9 ELISA Kits) expression

  7. In clinical samples of hepatocellular carcinom (HCC (show FAM126A ELISA Kits)), miR (show MLXIP ELISA Kits)-379-5p negatively correlated with FAK, which was up-regulated in HCC (show FAM126A ELISA Kits).

  8. Combining erlotinib with FAK inhibitor was also potent in vivo as evidenced by reduced tumor growth in the A549 mouse xenograft model.

  9. Increased focal adhesion kinase(FAK)activity.

  10. Results from immunohistochemical analyses in 9 benign, 19 premalignant, and 19 malignant oral tissues showed that the immunoreactivity of FAK was observed in 5 benign (56%), 19 premalignant (100%), and 18 malignant tissues (95%)

Xenopus laevis PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.

  2. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.

  3. work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development

  4. These data suggest an important role for the FERM domain in the activation of FAK.

  5. FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (show BDNF ELISA Kits), while phosphorylation at Y925 controls the rate of point contact turnover.

  6. Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.

  7. FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.

Mouse (Murine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. results suggest that LPS (show TLR4 ELISA Kits)-stimulated macrophage mediators attenuate both FAK and Src (show SRC ELISA Kits) activations in osteoblast, suggesting a novel role for TNFalpha (show TNF ELISA Kits) on osteoblast performance

  2. Report phosphorylation sites in focal adhesion kinase and putative new binding partners.

  3. data indicate that PTPalpha (show PTPRA ELISA Kits) and FAK, which are enriched in FAs (show FAS ELISA Kits), interact with IP3R1 (show ITPR1 ELISA Kits) at adjacent ER sites to spatially sequester IL-1 (show IL1A ELISA Kits)-induced Ca(2 (show CA2 ELISA Kits)+) signalling

  4. FAK-regulated signalling module PDK1 (show PDPK1 ELISA Kits)-Akt (show AKT1 ELISA Kits)-p70S6K (show RPS6KB1 ELISA Kits) that controls Src's intracellular trafficking operates at Src (show SRC ELISA Kits)-containing autophagosomes.

  5. Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes.

  6. FAK deletion correlates with increased phosphorylation of Tks-5 (tyrosine kinase substrate (show IRS2 ELISA Kits) with five SH3 domain (show ITSN1 ELISA Kits)) and reactive oxygen species production.

  7. Par4 (show F2RL3 ELISA Kits), CEBPB (show CEBPB ELISA Kits) and FAK form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT (show ITK ELISA Kits) and self-renewal

  8. LPS (show TLR4 ELISA Kits)-induced increases in intestinal TJP and intestinal inflammation were regulated by TLR4 (show TLR4 ELISA Kits)-dependent activation of the FAK/MyD88 (show MYD88 ELISA Kits)/IL-1R-associated kinase 4 signaling pathway.

  9. Inactivation of the FAK signaling pathway by either genetic or pharmacologic methods significantly sensitizes both murine and human PTEN-null T-ALL cells to PI3K/AKT (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) inhibition when cultured in vitro on feeder layer cells or a matrix and in vivo

  10. These data indicate that FAK might exaggerate NMDAR (show GRIN1 ELISA Kits)-mediated synaptic transmission in the spinal dorsal horn to sensitize nociceptive behaviors.

Cow (Bovine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. RhoA (show RHOA ELISA Kits) and membrane fluidity mediates the spatially polarized Src (show SRC ELISA Kits)/FAK activation in response to shear stress.

  2. XIAP (show XIAP ELISA Kits) plays an essential role in shear stress-stimulated FAK phosphorylation.

  3. mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C (show PKC ELISA Kits)

  4. These results suggest that TGF-beta1 (show TGFB1 ELISA Kits)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (show SRC ELISA Kits)-dependent and -independent pathways.

  5. Results suggest focal adhesion kinase is involved in thrombospondin-1 (show THBS1 ELISA Kits)-induced vascular smooth muscle cell migration.

FAK (PTK2) Antigen Profile

Antigen Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Gene names and symbols associated with PTK2

  • PTK2 protein tyrosine kinase 2 (PTK2) antibody
  • protein tyrosine kinase 2 (PTK2) antibody
  • protein tyrosine kinase 2 (Ptk2) antibody
  • protein tyrosine kinase 2 (ptk2) antibody
  • PTK2 protein tyrosine kinase 2 (Ptk2) antibody
  • Fadk antibody
  • FAK antibody
  • FAK1 antibody
  • FRNK antibody
  • mKIAA4203 antibody
  • p125FAK antibody
  • pp125FAK antibody
  • PPP1R71 antibody

Protein level used designations for PTK2

FADK 1 , FAK-related non-kinase polypeptide , PTK2 protein tyrosine kinase 2 , focal adhesion kinase 1 , focal adhesion kinase-related nonkinase , protein phosphatase 1 regulatory subunit 71 , protein phosphatase 1, regulatory subunit 71 , pp125FAK , protein-tyrosine kinase 2 , focal adhesion kinase pp125FAK , focal ashension kinase 1 , p41/p43FRNK , focal adhesion kinase

100058245 Equus caballus
5747 Homo sapiens
25614 Rattus norvegicus
399286 Xenopus laevis
14083 Mus musculus
396416 Gallus gallus
475108 Canis lupus familiaris
506270 Bos taurus
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