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The protein encoded by PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. Additionally we are shipping PNPLA3 Antibodies (92) and PNPLA3 Proteins (7) and many more products for this protein.
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Human PNPLA3 Primary Antibody for ELISA - ABIN1979134
Lake, Sun, Li, Kim, Johnson, Li, Revett, Shih, Liu, Paulsen, Gimeno: Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members. in Journal of lipid research 2005
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Among Mexicans, the PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (show PPP1R3B ELISA Kits) (rs4240624), and GCKR (show GCKR ELISA Kits) (rs780094) polymorphisms may be associated with a greater risk of chronic liver disease among overweight adults.
SNPs rs2896019 and rs3810622 significantly associated with increased risk of nonalcoholic fatty liver disease in Han Chinese population
The PNPLA3 148 I/M or M/M variants and CD4 (show CD4 ELISA Kits)(+) cell count were the only independent predictors of severe steatosis in patients with hepatitis C virus non-3 genotypes.
the PNPLA3 rs738409 was determined to be associated with hepatocellular carcinoma development in a cohort of Japanese patients with type 2 diabetes mellitus
PNPLA3 p.I148M variant represents the most important prosteatotic genetic risk factor. NAFLD (show TSC2 ELISA Kits) carriers of this variant should be followed up carefully, with elastography being ideally suited for this purpose.
The PNPLA3 p.I148M variant is associated with non-alcoholic fatty liver disease.
based on data from the HALT-C trial, the PNPLA3 CG/GG SNP at rs738409 is associated with fibrosis progression but not development of Hepatocellular Carcinoma in patients with Hepatitis C Virus Infection
transmembrane 6 superfamily 2 C/T or T/T variants in conjunction with patatin-like phospho-lipase (show LIPG ELISA Kits) domain-containing protein 3 (show HSPB3 ELISA Kits) G/G variants may be potential genetic risk factors for developing HCC (show FAM126A ELISA Kits) in alcohol-related cirrhosis.
Steatosis severity was independently associated with PNPLA3 rs738409 in large cohort of patients with genotype 1 Chronic hepatitis C.
I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing Nonalcoholic fatty liver disease.
Neither ablation nor overexpression of wild-type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M transgene causes steatosis.
PNPLA3 plays a role in remodeling TAG in lipid droplets, as they accumulate in response to food intake
adiponutrin/PNPLA3 is regulated by two key factors of the glycolytic and lipogenic pathways, raising the question of its implication in the metabolism of carbohydrates and lipids
data argue against a role for Pnpla3 loss-of-function in fatty liver disease or metabolic syndrome in mice.
Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin (show INS ELISA Kits) resistance in mice.
Microarray-based gene profiling showed that the expression level of PNPLA3 in hepatocytes is correlated with that of genes associated with the lipogenic pathway such as ME1 (show ME1 ELISA Kits), SPOT14 (show THRSP ELISA Kits), and SCD1 (show SCD ELISA Kits).
data suggest that murine ATGL (show PNPLA2 ELISA Kits) but not adiponutrin contributes to net adipocyte lipolysis and that ATGL (show PNPLA2 ELISA Kits) and adiponutrin are oppositely regulated by insulin (show INS ELISA Kits) both in vitro and in vivo
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.
, calcium-independent phospholipase A2-epsilon
, patatin-like phospholipase domain-containing protein 3