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PGC encodes an aspartic proteinase that belongs to the peptidase family A1. Additionally we are shipping PGC Kits (52) and PGC Proteins (22) and many more products for this protein.
Showing 10 out of 164 products:
Human Monoclonal PGC Primary Antibody for EIA, IHC (p) - ABIN1108614
Varis, Samloff, Ihämaki, Siurala: An appraisal of tests for severe atrophic gastritis in relatives of patients with pernicious anemia. in Digestive diseases and sciences 1979
Show all 5 references for 1108614
Pepsinogen-II 100 bp ins (show INS Antibodies)/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia.
Results suggest that rs9471643 CG and rs6458238 AG/AA genotypes have important roles in up-regulating PGC expression, which may partially explain why individuals with these favorable genotypes have decreased risks of getting gastric cancer.
Data show that SNP interactions among H. pylori-related genes PGC, PTPN11 (show PTPN11 Antibodies), and IL1B (show IL1B Antibodies), are associated with susceptibility to gastric carcinogenesis.
Serum pepsinogens I (PGI (show BGN Antibodies)) and II (PGII (show DCN Antibodies)), gastrin (show GAST Antibodies) 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA (show S100A8 Antibodies)) antigen among 309 consecutive patients, were measured.
The results highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer.
Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication.
High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions.
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 (show ERCC6 Antibodies) rs1917799 polymorphism was observed for the risk of gastric cancer.
Pepsin and pepsinogen in middle ear effusion are probably caused by LPR (show FAS Antibodies) and may be involved in the pathogenesis of OME.
High serum pepsinogen II is associated with gastric cancer development and activity of Helicobacter pylori-associated chronic gastritis.
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
, pepsinogen C
, pepsin C
, pepsinogen group II
, urinary pepsinogen 1
, Urinary pepsinogen 1