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anti-Pericentrin (PCNT) Antibodies

The protein encoded by PCNT binds to calmodulin and is expressed in the centrosome. Additionally we are shipping Pericentrin Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PCNT 5116 O95613
PCNT 309692  
PCNT 18541 P48725
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Top anti-Pericentrin Antibodies at antibodies-online.com

Showing 8 out of 12 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of Pericentrin on mouse neonate lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of anti-Pericentrin antibody. Immunofluorescent staining on NIH-3T3 cells. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated WB Western blot analysis of Pericentrin expression in HEK293T (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$375.83
Details
Human Rabbit Un-conjugated ICC, WB   100 μg Log in to see 8 to 10 Days
$815.83
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$581.17
Details
Human Rabbit Un-conjugated IF (p), IHC (p)   100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IC, WB   100 μg Log in to see 11 to 16 Days
$603.43
Details
Human Rabbit Un-conjugated   100 μL Log in to see 9 to 19 Days
$354.05
Details

PCNT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , ,


Rat (Rattus) ,


Mouse (Murine) ,
,
,

Top referenced anti-Pericentrin Antibodies

  1. Mouse (Murine) Monoclonal PCNT Primary Antibody for IF, WB - ABIN968665 : Doxsey, Stein, Evans, Calarco, Kirschner: Pericentrin, a highly conserved centrosome protein involved in microtubule organization. in Cell 1994 (PubMed)
    Show all 2 references for ABIN968665

More Antibodies against Pericentrin Interaction Partners

Fruit Fly (Drosophila melanogaster) Pericentrin (PCNT) interaction partners

  1. Cnn and PLP directly interact at two defined sites to coordinate the cell cycle-dependent rearrangement and scaffolding activity of the centrosome to permit normal centrosome organization, cell division, and embryonic viability.

  2. Basal body formation in the male testes and the production of functional sperm does not rely on the PLP-CaM (show CALM Antibodies) interaction, whereas production of functional mechanosensory neurons does.

  3. Data indicate that interphase centrioles are closely associated with Sas-4, Spd-2, Polo kinase (show PLK1 Antibodies), Pericentrin-like protein (Dplp), Asterless (show CEP152 Antibodies) (Asl (show ADSL Antibodies)), Plk4 (show PLK4 Antibodies) kinase, Centrosomin (show EIF3A Antibodies) (Cnn) and gamma-tubulin (show TUBG1 Antibodies).

  4. identification of CP309 which can bind to calmodulin (show CALM Antibodies); it is is required for microtubule nucleation mediated by centrosomes and it interacts with the gamma-tubulin (show TUBG1 Antibodies) small complex

Human Pericentrin (PCNT) interaction partners

  1. we identified two novel mutations in the PCNT gene associated with Microcephalic osteodysplastic primordial dwarfism type II and intracranial aneurysms

  2. PCNT has to be phosphorylated by PLK1 (show PLK1 Antibodies) to be a suitable substrate of separase (show ESPL1 Antibodies).

  3. Cep68 degradation allows Cep215 (show CDK5RAP2 Antibodies) removal from peripheral pericentriolar material (PCM (show PCMT1 Antibodies)) preventing centriole separation following disengagement, PCNT cleavage mediates Cep215 (show CDK5RAP2 Antibodies) removal from core of the PCM (show PCMT1 Antibodies) to inhibit centriole disengagement and duplication

  4. The CEP215 (show CDK5RAP2 Antibodies)-pericentrin interaction is required for centrosome maturation and subsequent bipolar spindle formation during mitosis.

  5. Data suggest that changes in the expression levels of PCNT in DS subjects may be involved into the molecular mechanism of Down's syndrome.

  6. PCNT gene mutation is associated with hematological abnormalities in patients with microcephalic osteodysplastic primordial dwarfism type II.

  7. Che-1 (show BCHE Antibodies) depletion abolishes the ability of Chk1 (show CHEK1 Antibodies) to bind pericentrin and to localize at centrosomes, which, in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 (show CDK1 Antibodies) and advances entry into mitosis.

  8. The pericentrin B cleavage is essential for timely centriole disengagement and duplication.

  9. Kendrin is a novel and crucial substrate for separase (show ESPL1 Antibodies) at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis.

  10. Expression of RRP1B, PCNT, KIF21A (show KIF21A Antibodies) and ADRB2 (show ADRB2 Antibodies) in leucocytes of Down's syndrome subjects, was analyzed.

Mouse (Murine) Pericentrin (PCNT) interaction partners

  1. Pericentrin is a key functional component of the unique acentriolar MTOCs of mouse oocytes, and plays an important role in regulating meiotic spindle assembly and/or stability.

  2. The mouse Pcnt(-/-) phenotype was associated with misdirected ventricular septal growth in the heart, decreased proliferative symmetric divisions in brain neural progenitors, and increased misoriented divisions in fibroblasts.

  3. Findings suggest distinct functional roles of several Pcnt variants in different ciliated tissues and sensory neurons, like the olfactory epithelium and the retina of the mouse

  4. A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice

  5. results confirm that MT1-MMP (show MMP14 Antibodies) cleaves pericentrin-2 in humans but not in mice and that mouse models of cancer probably cannot be used to critically examine MT1-MMP (show MMP14 Antibodies) functionality

  6. Pcnt was shown to be localized to the base of primary cilia in multiple embryonic tissues, in agreement with a recent study demonstrating the involvement of Pcnt in primary cilia formation using cultured mammalian cells.

  7. Pericentrin forms complexes with CHD3 (show CHD3 Antibodies) and CHD4 (show CHD4 Antibodies), but a distinct CHD3 (show CHD3 Antibodies)-pericentrin complex is required for centrosomal anchoring of pericentrin/gamma-tubulin (show TUBG1 Antibodies) and for centrosome integrity.

  8. pPKCdelta(Thr505) interacts with MTOC-associated proteins pericentrin and gamma-tubulin (show TUBG1 Antibodies), and plays a role in meiotic spindle organization in oocytes

  9. pericentrin is essential for the assembly of chemosensory cilia of olfactory receptor neurons, but it is not globally required for cilia formation in mammals.

Pericentrin (PCNT) Antigen Profile

Protein Summary

The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II.

Gene names and symbols associated with anti-Pericentrin (PCNT) Antibodies

  • pericentrin (PCNT) antibody
  • CG33957 gene product from transcript CG33957-RM (cp309) antibody
  • pericentrin (LOC100231943) antibody
  • pericentrin (pcnt) antibody
  • pericentrin (Pcnt) antibody
  • pericentrin (kendrin) (Pcnt) antibody
  • AKAP450 antibody
  • AW476095 antibody
  • C86676 antibody
  • CG6735 antibody
  • CG13459 antibody
  • CG18648 antibody
  • CG33957 antibody
  • Cp309 antibody
  • d-plp antibody
  • DIP2A antibody
  • Dmel\\CG33957 antibody
  • dplp antibody
  • KEN antibody
  • kendrin antibody
  • l(3)s2172 antibody
  • m239Asp antibody
  • m275Asp antibody
  • MOPD2 antibody
  • PACT antibody
  • PCN antibody
  • Pcnt2 antibody
  • PCNTB antibody
  • PCTN2 antibody
  • Plp antibody
  • pPlp antibody
  • SCKL4 antibody

Protein level used designations for anti-Pericentrin (PCNT) Antibodies

CG33957-PC , CG33957-PD , CG33957-PF , CG33957-PG , CG33957-PH , CG33957-PJ , CG33957-PK , CG33957-PL , CG33957-PM , CG33957-PN , CG33957-PO , CG33957-PP , cp309-PC , cp309-PD , cp309-PF , cp309-PG , cp309-PH , cp309-PJ , cp309-PK , cp309-PL , cp309-PM , cp309-PN , cp309-PO , cp309-PP , drosophila pericentrin like protein , lethal (3) s2172 , pericentrin , pericentrin-like , pericentrin-like protein , pericentrin/AKAP450 centrosomal targeting , kendrin , pericentrin B , pericentrin-2 , pericentrin-380 , pericentrin-B , DIP2 disco-interacting protein 2 homolog A , pericentrin (kendrin) , pericentrin 2 (kendrin) , pericentrin 2 , pericentrin-250 , pericentrin-360

GENE ID SPECIES
100055203 Equus caballus
3772382 Drosophila melanogaster
100231943 Taeniopygia guttata
100486558 Xenopus (Silurana) tropicalis
474062 Pan troglodytes
5116 Homo sapiens
424039 Gallus gallus
491613 Canis lupus familiaris
510855 Bos taurus
309692 Rattus norvegicus
18541 Mus musculus
Selected quality suppliers for anti-Pericentrin (PCNT) Antibodies
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