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PER2 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Additionally we are shipping PER2 Antibodies (109) and PER2 Kits (5) and many more products for this protein.
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This study showed that Lack of Association between Genetic Polymorphism of PER2 gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population
Results show that PER2 expression and stability is regulated by CSNK1D (show CSNK1D Proteins) which can itself be regulated by phosphorylation on its regulatory domain in a site-specific manner.
miR (show MLXIP Proteins)-21 as cardioprotective downstream target of Per2
Per2 is closely and negatively associated with the occurrence and development of ovarian cancer. Per2 expression, and the clinical stage and TNM (show ODZ1 Proteins) development of ovarian cancer were identified to be correlated.
results indicate the involvement of PER2 in the homeostatic process of sleep
Immunostaining of CLOCK and PER2 protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation
clock gene Per2 plays an important role in cell cycle progression and the balance of cell proliferation and apoptosis by regulation of the cyclin/CDK/CKI cell cycle network.
Low Per2 gene expression is associated with colorectal liver metastases.
The levels of circadian protein Per2 were significantly increased and E-cadherin (show CDH1 Proteins) was significantly decreased in the tissue of human esophageal cancer with metastasis as compared with non-metastatic esophageal cancer.
The effect of genotype AC or allele C of Per2 on insomnia was relatively stronger than that of high work stress, suggesting that individual's susceptibility should be taken into consideration when intervening and controlling insomnia of workers.
The Per2 function in the bone marrow is required for the regulation of life span in circulating erythrocytes.
these results identify Per2 as a negative regulator of Ly-biased haematopoietic stem cells and immune functions in response to DNA damage and ageing.
beta-amyloid protein (31-35) altered the expression of the Per1 and Per2 in the suprachiasmatic nucleus, hippocampus and heart. These findings provide experimental evidence for circadian rhythm disturbances in patients with Alzheimer's disease.
Circadian PER2 rhythm in the olfactory bulb of freely moving mice is organized by the nucleus circadian pacemaker, and is independent of the circadian behavioral rhythm
Study showed that Mecp2 de fi ciency causes a reduced amplitude in the PER2 expression rhythms of the suprachiasmatic nucleus providing a new insight into behavioral dysfunction caused by Mecp2 de fi ciency in Rett syndrome.
polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1 (show CRY1 Proteins)
Rate-limiting mitochondrial enzymes that process lipids and carbohydrates accumulate in a diurnal manner and are dependent on the clock proteins PER1 (show PER1 Proteins)/2. Diurnal regulation of mitochondrial respiration was blunted in PER1 (show PER1 Proteins)/2 knockout mice.
Decreased Bone Volume and Bone Mineral Density in the Tibial Trabecular Bone Is Associated with Per2 Gene by 405 nm Laser Stimulation
that the presence of a depressive state around the early active phase of activity may be related to impairment of rhythmicity and expression levels of Per1 (show PER1 Proteins) and Per2 genes under abnormal light-dark conditions
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
period homolog 2
, circadian clock protein PERIOD 2
, period 2
, period circadian protein 2
, period circadian protein homolog 2