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PER2 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Additionally we are shipping PER2 Antibodies (95) and PER2 Kits (5) and many more products for this protein.
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Per2 is closely and negatively associated with the occurrence and development of ovarian cancer. Per2 expression, and the clinical stage and TNM (show ODZ1 Proteins) development of ovarian cancer were identified to be correlated.
results indicate the involvement of PER2 in the homeostatic process of sleep
Immunostaining of CLOCK and PER2 protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation
clock gene Per2 plays an important role in cell cycle progression and the balance of cell proliferation and apoptosis by regulation of the cyclin/CDK/CKI cell cycle network.
Low Per2 gene expression is associated with colorectal liver metastases.
The levels of circadian protein Per2 were significantly increased and E-cadherin (show CDH1 Proteins) was significantly decreased in the tissue of human esophageal cancer with metastasis as compared with non-metastatic esophageal cancer.
The effect of genotype AC or allele C of Per2 on insomnia was relatively stronger than that of high work stress, suggesting that individual's susceptibility should be taken into consideration when intervening and controlling insomnia of workers.
possible circadian rhythm in full-term placental expression
Data suggest that PER2 functions as the only clock gene needed to maintain undifferentiated state of endothelial progenitor cells; expression of PER2-regulatory microRNA, miR (show MLXIP Proteins)-92a, is down-regulated in diabetic retinopathy.
ARNTL (show ARNTL Proteins) and PER2 genetic variants associate in psychotic disorders Depresssion
Circadian PER2 rhythm in the olfactory bulb of freely moving mice is organized by the nucleus circadian pacemaker, and is independent of the circadian behavioral rhythm
Study showed that Mecp2 (show MECP2 Proteins) de fi ciency causes a reduced amplitude in the PER2 expression rhythms of the suprachiasmatic nucleus providing a new insight into behavioral dysfunction caused by Mecp2 (show MECP2 Proteins) de fi ciency in Rett syndrome.
polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1 (show CRY1 Proteins)
Rate-limiting mitochondrial enzymes that process lipids and carbohydrates accumulate in a diurnal manner and are dependent on the clock proteins PER1 (show PER1 Proteins)/2. Diurnal regulation of mitochondrial respiration was blunted in PER1 (show PER1 Proteins)/2 knockout mice.
Decreased Bone Volume and Bone Mineral Density in the Tibial Trabecular Bone Is Associated with Per2 Gene by 405 nm Laser Stimulation
that the presence of a depressive state around the early active phase of activity may be related to impairment of rhythmicity and expression levels of Per1 (show PER1 Proteins) and Per2 genes under abnormal light-dark conditions
Data show that early doors period 2 (PER2) I324N mutation (Per2 Edo) reveals a direct causal link between the molecular structure of the PER2 PAS (show PASK Proteins) domain and the pace of suprachiasmatic nucleus (SCN (show SRI Proteins)) circadian timekeeping.
PER2 ablation in the liver abolishes food anticipation via decreased beta-hydroxybutyrate production.
hnRNP C (show HNRNPC Proteins) and hnRNP H (show HNRNPH2 Proteins) bind to the 3'-UTR of the circadian clock gene Period 2 (mPer2).
Histone monoubiquitination by Clock-Bmal1 (show ARNTL Proteins) complex marks Per1 (show PER1 Proteins) and Per2 genes for circadian feedback.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
period homolog 2
, circadian clock protein PERIOD 2
, period 2
, period circadian protein 2
, period circadian protein homolog 2