Piwi-Like 4 (Drosophila) Proteins (PIWIL4)

PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008].. Additionally we are shipping PIWIL4 Antibodies (72) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIWIL4 143689 Q7Z3Z4
PIWIL4 330890 Q8CGT6
Rat PIWIL4 PIWIL4 689972  
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Top PIWIL4 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

PIWIL4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Piwi-Like 4 (Drosophila) (PIWIL4) Interaction Partners

Human Piwi-Like 4 (Drosophila) (PIWIL4) interaction partners

  1. PIWIL2 and PIWIL4 genes expression in synovial fibroblasts of the rheumatoid arthritis patients.PIWIL4 does not regulate methylation or expression of LINE-1.

  2. MiR (show MLXIP Proteins)-384 functioned as tumor suppressor by decreasing PIWIL4 in glioma cell lines.

  3. study demonstrates the presence of PIWI (show PIWIL1 Proteins)-like proteins in somatic cells and the possible role of HIWI2 in preserving the functional integrity of epithelial cells probably by modulating the phosphorylation status of Akt (show AKT1 Proteins).

  4. PIWIL4 is highly expressed in both breast cancer tissues and the cytoplasm of MDA-MB-231 cells derived from breast cancer. Reducing PIWIL4 expression drastically impairs the migration ability of MDA-MB-231 cells, significantly increases their apoptosis, and mildly affects their proliferation.

  5. Results show that three CpG loci within FYN (show FYN Proteins) were hypermethylated in obese individuals, while obesity was associated with lower methylation of CpG loci within PIWIL4 and TAOK3 (show TAOK3 Proteins).

  6. study to evaluate frequency of PIWIL4 genetic variants in order to better define the relationship between PIWIL4 SNPs and defective spermatogenesis and specific spermatogenic disorders; results suggest genetic and epigenetic alterations that affect the PIWI pathway contribute to unsuccessful sperm production

  7. Data suggest that MIWI2 and MIWI2-associated piRNAs have functions beyond TE suppression.

  8. associations were determined between the Piwi-like family member expression levels and clinicopathological parameters of ccRCC, suggesting a potential role for these genes/proteins in ccRCC diagnostics and tumorigenesis

  9. we identified a significant association between the expression of Piwi-like 2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients.

  10. PIWIL4 might play an oncogenic role in cervical cancer

Mouse (Murine) Piwi-Like 4 (Drosophila) (PIWIL4) interaction partners

  1. Miwi2 deficiency had only a minor impact on piRNA biogenesis. Miwi2-knockout mice indicated overexpression of several LINE1 TE families.

  2. piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.

  3. MIWI2 is not solely necessary for hematopoiesis within the normal life span of a mouse.

  4. Mice with a global deletion of all three piwi (show PIWIL1 Proteins) genes, Miwi (show PIWIL1 Proteins), Mili, and Miwi2, are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.

  5. Icariin induced a decrease in piwil4 protein expression and piwil4 silencing significantly enhanced the cytotoxic effects of icariin in MLTC-1 cells.

  6. Results identify TDRD9 as a functional partner of MIWI2 and indicate that the tudor-piwi association is a conserved feature, while two separate axes, TDRD9-MIWI2 and TDRD1-MILI, cooperate in the piwi-small RNA pathway in the mouse male germline.

  7. Data strongly suggest that MILI and MIWI2 play essential roles in establishing de novo DNA methylation (show HELLS Proteins) of retrotransposons in fetal male germ cells.

  8. purified the three murine Piwi (show PIWIL1 Proteins) family proteins, MILI, MIWI (show PIWIL1 Proteins), and MIWI2, from mouse germ cells and characterized their interacting protein partners

PIWIL4 Protein Profile

Protein Summary

PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003

Gene names and symbols associated with PIWIL4

  • piwi-like 4 (Drosophila) (PIWIL4)
  • piwi-like RNA-mediated gene silencing 4 (PIWIL4)
  • piwi-like RNA-mediated gene silencing 4 (Piwil4)
  • 9230101H05Rik protein
  • HIWI2 protein
  • Miwi2 protein

Protein level used designations for PIWIL4

piwi-like 4 , piwi-like protein 4 , mAgo5 , piwi-like homolog 4

485123 Canis lupus familiaris
143689 Homo sapiens
330890 Mus musculus
689972 Rattus norvegicus
509545 Bos taurus
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