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Platelet-Activating Factor Receptor Proteins (PTAFR)

PTAFR encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. Additionally we are shipping PTAFR Antibodies (40) and PTAFR Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTAFR 5724 P25105
PTAFR 19204 Q62035
Rat PTAFR PTAFR 58949 P46002
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Top PTAFR Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days

PTAFR Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Platelet-Activating Factor Receptor (PTAFR) Interaction Partners

Human Platelet-Activating Factor Receptor (PTAFR) interaction partners

  1. PAFR is overexpressed in NSCLC as well as in breast, colorectal, and gastric carcinomas. PAFR expression correlates with clinical stages, survival time, and distant metastasis. PAF (show KIAA0101 Proteins)/PAFR signaling also upregulated IL6 (show IL6 Proteins) expression and STAT3 (show STAT3 Proteins) activation.

  2. we made the first demonstration that dysregulation of PAFR and the positive regulatory loop between PAFR and pAKT (show AKT1 Proteins) contribute to malignant progression of esophageal squamous cell carcinoma

  3. Data support an important role for PAFR in tumor growth and suggest that engagement of PAFR interferes with selected pathways in macrophages, changing their phenotype into that of a regulatory with suppressor activities. [review]

  4. Epithelial PAFr expression is upregulated in smokers, especially in those with COPD (show ARCN1 Proteins), and is not obviously affected by inhaled corticosteroid therapy.

  5. Results suggest that WEB2086 and AG1478 are synergistic in ovarian cancer cells with high expression of both platelet-activating factor receptor (PAFR) and epidermal growth factor receptor (EGFR (show EGFR Proteins)).

  6. PAFR may have an important role in modulating the cisplatin sensitivity of ovarian cancer cells.

  7. patients presenting elevated PAFR expression had significantly longer survival times compared to those with low PAFR expression (log-rank test, p<0.001).

  8. oxLDL induces the recruitment of PAFR and CD36 (show CD36 Proteins) into the same lipid rafts, which is important for oxLDL uptake and IL-10 (show IL10 Proteins) production

  9. Data suggest PAF/PAF (show KIAA0101 Proteins) receptor signaling exerts proinflammatory effect on neutrophil via down-regulation of LXRa (liver X receptor alpha (show NR1H3 Proteins)) and target genes (ATP-binding cassette transporter (show ABCA4 Proteins) (ABC (show ABCB6 Proteins)) A1, ABC (show ABCB6 Proteins) G1, sterol response element binding protein 1c).

  10. Inhibition of platelet aggregation by lipoteichoic acid was blocked using a monoclonal anti-PafR antibody and Ginkgolide B,a well-defined PafR antagonist, demonstrating that the LTA (show LTA Proteins) inhibitory signal occurs via PafR.

Mouse (Murine) Platelet-Activating Factor Receptor (PTAFR) interaction partners

  1. In the absence of PAFR signalling, monocytes and macrophages acquire a pro-inflammatory phenotype, resulting in adipose tissue inflammation and metabolic dysfunction.

  2. Data (including data from studies in knockout mice) suggest that signal transduction via platelet-activating factor (PAF (show KIAA0101 Proteins)) and PAF receptor is involved in regulation of lipid metabolism/inflammation in liver of mice on high-refined carbohydrate diet.

  3. ExoU activates NF-kappaB (show NFKB1 Proteins) by PAFR signalling, which in turns enhances PAFR expression, highlighting an important mechanism of amplification of response to this P. aeruginosa toxin.

  4. In PAF receptor-knockout mice, diet-induced obesity is exacerbated.

  5. Bacteria did not associate with PAFR, indicating an indirect role of PAFR in pneumococcal adhesion to endothelial cells.

  6. PAFR deficiency resulted in less inflammation in adipose tissue and improvement in glucose homeostasis in mice fed a high-carbohydrate diet

  7. PAFR and CD36 (show CD36 Proteins) coimmunoprecipitated with flotillin-1 (show FLOT1 Proteins), a constitutive lipid raft protein, and disruption of these membrane microdomains by methyl-beta-cyclodextrin reduced apoptotic cells phagocytosis

  8. Our findings establish the existence of a functional partnership PAF-R/eNOS (show NOS3 Proteins) on endothelial cell plasma membrane.

  9. Activation of PAF-receptor induces regulatory dendritic cells through PGE2 and IL-10 (show IL10 Proteins).

  10. PAFR signaling contributes to a pro-inflammatory environment in the model of obstructive nephropathy, favoring the fibrotic process.

Rabbit Platelet-Activating Factor Receptor (PTAFR) interaction partners

  1. The gene expression of PAFR was upregulated, as an effect of light exposure, in the third eyelid but not in the cornea.

Cow (Bovine) Platelet-Activating Factor Receptor (PTAFR) interaction partners

  1. PAF (show KIAA0101 Proteins) and luteinizing hormone signaling plays an important role in regulating the production of excessive oxidants.

  2. The results provide clear evidence for expression of PAFr in bovine granulosa cells and its functional involvement in PAF (show KIAA0101 Proteins)/PAFr-mediated stimulation of cell recruitment.

PTAFR Protein Profile

Protein Summary

This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PTAFR

  • platelet-activating factor receptor (ptafr)
  • platelet-activating factor receptor (PTAFR)
  • platelet-activating factor receptor (Ptafr)
  • platelet-activating factor receptor (LOC100354046)
  • platelet-activating factor receptor-like (LOC100523973)
  • MGC52896 protein
  • MGC160177 protein
  • PAF-R protein
  • PAFr protein

Protein level used designations for PTAFR

platelet-activating factor receptor , PAF-R , PAF receptor , PAFr

379327 Xenopus laevis
443041 Ovis aries
469249 Pan troglodytes
493365 Xenopus (Silurana) tropicalis
100590550 Nomascus leucogenys
5724 Homo sapiens
19204 Mus musculus
58949 Rattus norvegicus
100354046 Oryctolagus cuniculus
100720710 Cavia porcellus
487336 Canis lupus familiaris
518283 Bos taurus
100860976 Capra hircus
428209 Gallus gallus
101104560 Ovis aries
716788 Macaca mulatta
100523973 Sus scrofa
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