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Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. Additionally we are shipping PLAG1 Antibodies (62) and PLAG1 Kits (9) and many more products for this protein.
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The Thr34 of PLAG1 is critical for LpMab-10 recognition.
Data indicate that SLIT2 (show SLIT3 Proteins), miR (show MLXIP Proteins)-218-1, RET (show RET Proteins)/PLAG1 and SLIT2 (show SLIT3 Proteins)/ROBO1 (show ROBO1 Proteins) pathway involved in Hirschsprung's disease.
Altogether, these data suggest that HMGA2 is an upstream activator of PLAG1.
Report illustrates two different tumorigenic pathways implicating PLAG1 in lipoblastoma: amplification through multiple copies of a small marker chromosome derived from chromosome 8, and a paracentric inversion of the long arm of chromosome 8. Review.
The nuclear import of PLAG1 by KPNA2 (show KPNA2 Proteins) is essential for the role of KPNA2 (show KPNA2 Proteins) in HCC (show FAM126A Proteins) cells.
Extraskeletal myxoid chondrosarcoma of the vulva with PLAG1 gene activation: molecular genetic characterization of 2 cases
Fluorescence in situ hybridization for PLAG1 or HMGA2 can be used to distinguish between pleomorphic adenoma and carcinoma ex-pleomorphic adenoma and their morphologic mimics.
lipoblastoma is a group of lipomatous tumors with PLAG1 rearrangement and overexpression.
These results suggest that PLAG1 and CYLD do not play a role in ACC tumorigenesis.
Lacrimal and salivary gland PAs and Ca-ex-PAs have similar genomic profiles and frequently overexpress the PLAG1 oncoprotein. Copy number gains involving 9p23-p22.3 (NFIB) and 22q12-qter (PDGFB) may be of importance for disease progression.
This study demonstrates a strong association of early life body weight with pleiomorphic adenoma gene 1 (PLAG1) genotype in Holstein-Friesian dairy calves. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype.
Forced expression of PLAG1 under the control of the Pdx1 (show PDX1 Proteins) or Ngn3 (show NEUROG3 Proteins) promoter in murine pancreas induces different degrees of endocrine hormone imbalances.
Data indicate a plausible Plag1-Egr1 (show EGR1 Proteins)-CD44 (show CD44 Proteins) regulatory pathway in the T-ICs (show DNAI1 Proteins) of pleomorphic adenomas.
Plag1 disruption in mouse differentially affects pre- and postnatal growth and development of organs, with reproductive repercussions
aP2 (show TFAP2A Proteins)-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice.
Demonstrate upregulation of several genes associated with Igf and Wnt signalling in PLAG1-induced pleomorphic adenomas. Inactivation of Igf2 delays tumour development.
Suggest an important role for furin (show FURIN Proteins) in PLAG1-induced salivary gland tumorigenesis in mice.
results establish the oncogenic potential of PLAG1 in mammary glands of mice and point towards contributing roles of Igf and Wnt (show WNT2 Proteins) signaling
distinct loci exist for growth and fatness in the two populations and identified HMGA1 (show HMGA1 Proteins) and PLAG1 as strong candidate genes on SSC7 and SSC4, respectively.
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.
pleiomorphic adenoma gene 1
, zinc finger protein PLAG1-like
, pleiomorphic adenoma gene 1 protein
, zinc finger protein PLAG1
, COL1A2/PLAG1 fusion
, C2H2 zinc finger protein PLAG1