anti-Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) Antibodies

PABPCP2 encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails.

list all antibodies Gene Name GeneID
PABPCP2 728773
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Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB Western Blot analysis of PABPCP2 expression in transfected 293T cell line by PABPCP2 MaxPab polyclonal antibody.Lane 1: PABPCP2 transfected lysate(29.59 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 11 to 12 Days
$430.00
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PABPCP2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human


More Antibodies against Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 Interaction Partners

Human Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) interaction partners

  1. Whereas PABPN1 (show PABPN1 Antibodies) strongly increases the activity of its cognate poly(A) polymerase (show PAPOLA Antibodies) in vitro, Pab2 (show PABPN1 Antibodies) was unable to stimulate Pla1 (show POU2F3 Antibodies) to any significant extent.

  2. The described is the mRNA degradation poly(A) tail exosome targeting (PAXT) connection, which comprises the ZFC3H1 Zn-knuckle protein as a central link between MTR4 (show SKIV2L2 Antibodies) and the nuclear poly(A)-binding protein PABPN1 (show PABPN1 Antibodies).

  3. PABPN1 (show PABPN1 Antibodies) aggregates are able to trap TNNT3 pre-mRNA, driving it outside nuclear speckles, leading to an altered SC35 (show SRSF2 Antibodies)-mediated splicing.

  4. The levels of these 6 cytokines were not altered in expPABPN1 carriers at a pre-symptomatic stage, suggesting that this group of cytokines is a potential biomarker for muscle weakness in OPMD. Correlation pattern of expression levels could be a novel measurer for disease state

  5. Large cohort study demonstrated that in heterozygous and homozygous patients with oculopharyngeal muscular dystrophy, the mean age at diagnosis and the severity of the clinical symptoms correlate to the number of PABPN1 (GCN) repeats. Homozygous patients showed the worse phenotype, suggesting a gene-dose effect in addition to the repeat number expansion.

  6. we found a polyadenylation-dependent 3' end maturation pathway for the human telomerase RNA that relies on the nuclear poly(A)-binding protein PABPN1 (show PABPN1 Antibodies) and the poly(A)-specific RNase PARN (show PARN Antibodies).

  7. Many ribozymes were assayed and validated, including four ribozymes targeting the transcript of a disease-causing gene (a mutant version of PABPN1 (show PABPN1 Antibodies)).

  8. Studied if the stability of the RNP (show RNPC3 Antibodies) domain of PABPN1 (show PABPN1 Antibodies) or domain swapping within the RNP (show RNPC3 Antibodies) domain may add to fibril formation.

  9. This function is mediated by the concerted actions of the nuclear poly(A) binding protein PABPN1 (show PABPN1 Antibodies), poly(A) polymerase (PAP (show PAPOLA Antibodies)), and the nuclear exosome complex, a pathway we have named PABPN1 (show PABPN1 Antibodies) and PAP (show REG3A Antibodies)-mediated RNA decay (PPD (show HPD Antibodies))

  10. These findings demonstrate a role for PABPN1 (show PABPN1 Antibodies) in rescuing several cytopathological features of TDP-43 (show TARDBP Antibodies) proteinopathy by increasing the turnover of pathologic proteins.

Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) Antigen Profile

Protein Summary

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.

Gene names and symbols associated with PABPCP2

  • poly(A) binding protein, cytoplasmic 1 pseudogene 2 (PABPC1P2) antibody
  • poly(A) binding protein, nuclear 1 (PABPN1) antibody
  • OPMD antibody
  • PAB2 antibody
  • PABII antibody
  • PABP-2 antibody
  • PABP2 antibody
  • PABP4 antibody
  • PABPCP2 antibody
  • PABPCP4 antibody

Protein level used designations for PABPCP2

poly(A) binding protein 2 , poly(A) binding protein II , polyadenylate-binding protein 2

GENE ID SPECIES
728773 Homo sapiens
8106 Homo sapiens
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