Polybromo 1 Proteins (PBRM1)

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. Additionally we are shipping Polybromo 1 Antibodies (41) and Polybromo 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PBRM1 55193 Q86U86
PBRM1 66923  
Rat PBRM1 PBRM1 306254  
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Top Polybromo 1 Proteins at antibodies-online.com

Showing 4 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$880.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant PBRM1 (23-156) activity using AlphaScreen. PBRM1 (23-156) was used in an AlphaScreen® assay to generate a titration curve demonstrating the signal response in the presence of modified peptide substrate at increasing protein concentrations. This data was generated and kindly provided courtesy of ChemPartner. Recombinant PBRM1 (23-156) protein gel. PBRM1 (23-156) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg Log in to see 1 to 2 Days
$472.50
Details

PBRM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, , ,
Mouse (Murine)

More Proteins for Polybromo 1 (PBRM1) Interaction Partners

Human Polybromo 1 (PBRM1) interaction partners

  1. Knockdown of PBRM1 in colon cancer cells increased the expression of two receptor genes (RIG-I (show DDX58 Proteins) and MDA5 (show IFIH1 Proteins)) and upregulated interferon (show IFNA Proteins) (IFN)-related and inflammation-related gene signatures. Lower PBRM1 expression was associated with advanced pathological grade and poorer survival of colorectal cancer (CRC (show CALR Proteins)) patients, indicating that PBRM1 could serve as a potential prognostic biomarker for CRC (show CALR Proteins).

  2. kidney-specific deletion of Vhl (show VHL Proteins) and Pbrm1, but not either gene alone, results in bilateral, multifocal, transplantable clear cell kidney cancers.

  3. PBRM1 mutation is associated with small Cell Lung Cancer.

  4. These findings indicate that PBRM1 alters cell cycle progression and inhibits proliferation and migration of renal cell carcinoma (show MOK Proteins) ACHN (show LARP6 Proteins) cells through the chemokine/chemokine (show CCL1 Proteins) receptor pathway.

  5. our integrative analysis suggested that methylation and miRNA alterations were likely the downstream events associated with PBRM1 truncation mutations. In summary, this study provided some important insights into the understanding of tumorigenesis driven by PBRM1 truncated mutations in Clear cell renal cell carcinoma (show MOK Proteins) (ccRCC). The approach may be applied to many driver genes in various cancers.

  6. BAP1 (show RNF2 Proteins) and PBRM1 loss is seen frequently in intrahepatic cholangiocarcinoma

  7. PBRM1 gene deletion is associated with chordoma.

  8. conclude that four of the BDs act together to target PBRM1 to sites on chromatin; when a single BD is mutated, PBRM1 no longer controls gene expression properly, leading to increased cell proliferation

  9. Synthetic lethality screening identifies TIP60 (show KAT5 Proteins)-dependent radiation sensitivity in the absence of BAF180.

  10. Functionally, suppression of PBRM1 expression promoted cell proliferation and cell cycle progression

Mouse (Murine) Polybromo 1 (PBRM1) interaction partners

  1. Data suggest BAF180 protein as a critical regulator of cellular senescence and HSC (show FUT1 Proteins) homeostasis, which is at least partially regulated through BAF180-mediated suppression of cell cycle regulator p21 expression.

  2. kidney-specific deletion of Vhl (show VHL Proteins) and Pbrm1, but not either gene alone, results in bilateral, multifocal, transplantable clear cell kidney cancers.

  3. Data demonstrate a function for BAF180 in promoting genome stability that is distinct from its well-characterized role in transcriptional regulation.

  4. BAF180 is a repressor of IL-10 (show IL10 Proteins) transcription in Th2 cells and suggest that the differential recruitment of different SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) subtypes can have direct consequences on chromatin structure and gene transcription.

  5. BAF180 is critical for coronary vessel formation.

Polybromo 1 (PBRM1) Protein Profile

Protein Summary

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.

Gene names and symbols associated with Polybromo 1 Proteins (PBRM1)

  • polybromo 1 (PBRM1)
  • polybromo 1 L homeolog (pbrm1.L)
  • protein polybromo-1 (LOC100170602)
  • polybromo 1 (pbrm1)
  • polybromo 1 (Pbrm1)
  • 2610016F04Rik protein
  • AI507524 protein
  • BAF180 protein
  • Pb1 protein
  • RGD1565549 protein

Protein level used designations for Polybromo 1 Proteins (PBRM1)

polybromo 1 , protein polybromo-1 , BRG1-associated factor 180 , polybromo-1D , glutamate receptor interacting protein 2 , polybromo 1 protein , 2310032M22Rik

GENE ID SPECIES
460430 Pan troglodytes
495429 Xenopus laevis
100170602 Xenopus (Silurana) tropicalis
55193 Homo sapiens
565366 Danio rerio
396074 Gallus gallus
476593 Canis lupus familiaris
506557 Bos taurus
66923 Mus musculus
306254 Rattus norvegicus
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