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This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. Additionally we are shipping Polybromo 1 Antibodies (41) and Polybromo 1 Kits (3) and many more products for this protein.
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Knockdown of PBRM1 in colon cancer cells increased the expression of two receptor genes (RIG-I (show DDX58 Proteins) and MDA5 (show IFIH1 Proteins)) and upregulated interferon (show IFNA Proteins) (IFN)-related and inflammation-related gene signatures. Lower PBRM1 expression was associated with advanced pathological grade and poorer survival of colorectal cancer (CRC (show CALR Proteins)) patients, indicating that PBRM1 could serve as a potential prognostic biomarker for CRC (show CALR Proteins).
kidney-specific deletion of Vhl (show VHL Proteins) and Pbrm1, but not either gene alone, results in bilateral, multifocal, transplantable clear cell kidney cancers.
PBRM1 mutation is associated with small Cell Lung Cancer.
These findings indicate that PBRM1 alters cell cycle progression and inhibits proliferation and migration of renal cell carcinoma (show MOK Proteins) ACHN (show LARP6 Proteins) cells through the chemokine/chemokine (show CCL1 Proteins) receptor pathway.
our integrative analysis suggested that methylation and miRNA alterations were likely the downstream events associated with PBRM1 truncation mutations. In summary, this study provided some important insights into the understanding of tumorigenesis driven by PBRM1 truncated mutations in Clear cell renal cell carcinoma (show MOK Proteins) (ccRCC). The approach may be applied to many driver genes in various cancers.
BAP1 (show RNF2 Proteins) and PBRM1 loss is seen frequently in intrahepatic cholangiocarcinoma
PBRM1 gene deletion is associated with chordoma.
conclude that four of the BDs act together to target PBRM1 to sites on chromatin; when a single BD is mutated, PBRM1 no longer controls gene expression properly, leading to increased cell proliferation
Synthetic lethality screening identifies TIP60 (show KAT5 Proteins)-dependent radiation sensitivity in the absence of BAF180.
Functionally, suppression of PBRM1 expression promoted cell proliferation and cell cycle progression
Data suggest BAF180 protein as a critical regulator of cellular senescence and HSC (show FUT1 Proteins) homeostasis, which is at least partially regulated through BAF180-mediated suppression of cell cycle regulator p21 expression.
Data demonstrate a function for BAF180 in promoting genome stability that is distinct from its well-characterized role in transcriptional regulation.
BAF180 is a repressor of IL-10 (show IL10 Proteins) transcription in Th2 cells and suggest that the differential recruitment of different SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) subtypes can have direct consequences on chromatin structure and gene transcription.
BAF180 is critical for coronary vessel formation.
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.
, protein polybromo-1
, BRG1-associated factor 180
, glutamate receptor interacting protein 2
, polybromo 1 protein