You are viewing an incomplete version of our website. Please click to reload the website as full version.

Polypyrimidine Tract Binding Protein 1 Proteins (PTBP1)

PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Additionally we are shipping PTBP1 Antibodies (78) and PTBP1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat PTBP1 PTBP1 302879  
PTBP1 5725 P26599
PTBP1 19205  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top PTBP1 Proteins at

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Mammalian Cells Human DYKDDDDK Tag 100 μg Log in to see 13 to 16 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

PTBP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Polypyrimidine Tract Binding Protein 1 (PTBP1) Interaction Partners

Xenopus laevis Polypyrimidine Tract Binding Protein 1 (PTBP1) interaction partners

  1. inactivation of both exosc9, which encodes a component of the RNA exosome, and ptbp1, which encodes an RNA-binding protein abundant in Xenopus embryonic skin, impairs embryonic Xenopus skin development.

  2. Polypyrimidine tract binding protein prevents activity of an intronic regulatory element that promotes usage of a composite 3'-terminal exon

Human Polypyrimidine Tract Binding Protein 1 (PTBP1) interaction partners

  1. findings point to PKM2 and PTBP1 as new potential therapeutic targets to improve response of PDAC to chemotherapy

  2. PTBP1 and PTBP2 (show PTBP2 Proteins) impaired autoregulation of SRSF3 (show SRSF3 Proteins) in oral squamous cell carcinoma cancer cells.

  3. Results suggest that the role of polypyrimidine tract binding protein 1 (PTBP1) in tumorigenesis may be partly mediated by its regulation of cdc42 (show CDC42 Proteins) GTP-binding protein (CDC42 (show CDC42 Proteins)) alternative splicing and CDC42 (show CDC42 Proteins)-v2 might function as a tumor suppressor.

  4. Data indicate that polypyrimidine tract-binding protein (PTBP1) is preferentially overexpressed in clinical colorectal cancers

  5. PTB/hnRNP1 binds to the 3'UTR of Human Astrovirus-8 and is required or participates in viral replication.

  6. Data show that the protein levels of polypyrimidine tract binding protein 1 (PTBP1) and adenosine deaminase RNA-specific (show ADAR Proteins) binding protein ADAR1 (show ADAR Proteins) were cooperatively expressed in glioma tissues and cells.

  7. Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms

  8. HUR (show ELAVL1 Proteins) competes with the host protein PTB, which is a negative regulator of hepatitis C virus replication.

  9. RBFOX proteins can facilitate the splicing of micro-exons. We also found that PTBP1 likely regulates the inclusion of micro-exons, possibly by repressing the inclusion of micro-exons that are enhanced by RBFOX proteins and other splicing factors.

  10. ABLIM1 (show ABLIM1 Proteins) splicing is regulated by several splice factors, including MBNL (show MBNL1 Proteins) family proteins, CELF1 (show CELF1 Proteins), 2 and 6, and PTBP1, using a cellular splicing assay.

Mouse (Murine) Polypyrimidine Tract Binding Protein 1 (PTBP1) interaction partners

  1. showed polypyrimidine tract binding protein (PTBP)-dependent alternative splicing of CaMKIIalpha transcripts in the lens

  2. This may account for the tight correlation between Hps1 with Ptbp1 expression levels observed across mammalian tissues.

  3. The expression levels of three splicing factors, ESRP1 (show ESRP1 Proteins), PTB and SF2/ASF (show SRSF1 Proteins), are significantly altered during cardiac hypertrophy in mice.

  4. Study reports that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR (show MLXIP Proteins)-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons.

  5. PTB regulates the precise expression of CDK11(p58 (show CDK11B Proteins)) through direct interaction with CDK11(p58 (show CDK11B Proteins)) IRES and promotes M phase progression in ES cells.

  6. The polypyrimidine tract binding proteins PTBP1 and PTBP2 (show PTBP2 Proteins) repressed Psd-95 (show DLG4 Proteins) (also known as Dlg4 (show DLG4 Proteins)) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay.

  7. PTBP1 is not required for the earliest isovolumetric divisions and differentiation steps of the zygote up to the formation of the blastocyst.

  8. RBM4 (show RBM4 Proteins) may synergize its effect on muscle cell-specific alternative splicing by down-regulating PTB expression and antagonizing the activity of PTB in exon selection

  9. splicing repressors hnRNP A1 and A2, as well as the polypyrimidine-tract-binding protein PTB, contribute to control of pyruvate kinase isoform M1 and M2 expression

  10. Data indicate that PTB is essential for early mouse development and ES cell proliferation.

Zebrafish Polypyrimidine Tract Binding Protein 1 (PTBP1) interaction partners

  1. Data report on a zebrafish maternal-effect mutant, brom bones, which is defective in the cytosolic Ca(2 (show CA2 Proteins)+) rise and subsequent egg activation events, including cortical granule exocytosis and cytoplasmic segregation [brom bones].

  2. Two stretches of polypyrimidine tracts designated PPT1 and PPT2 which influence the IRES activity of cx55.5 protein were identified; deletion of PPT1 results in an appreciable decrease of the IRES activity

Arabidopsis thaliana Polypyrimidine Tract Binding Protein 1 (PTBP1) interaction partners

  1. PTB1 is a splicing factor (show SLU7 Proteins) that influences alternative splicing and acts at the polypyrimidine tract.

  2. Alternative splicing (AS) patterns as well as the expression of key flowering regulators were massively changed in a PTB1/2 level-dependent manner.

  3. AtPTB1 and AtPTB2 are widely expressed in almost all tissues, with the highest expression levels in late-maturing and mature pollen grains, and are crucial for pollen germination. [AtPTB1]

PTBP1 Protein Profile

Protein Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with PTBP1

  • polypyrimidine tract binding protein 1 (ptbp1-b)
  • polypyrimidine tract-binding protein (Smptb)
  • polypyrimidine tract-binding protein (NAEGRDRAFT_80143)
  • polypyrimidine tract-binding protein (LOC100285404)
  • polypyrimidine tract binding protein 1 (PTBP1)
  • polypyrimidine tract binding protein 1 (ptbp1-a)
  • polypyrimidine tract binding protein 1 (Ptbp1)
  • polypyrimidine tract binding protein 1a (ptbp1a)
  • polypyrimidine tract-binding protein 1 (PTB1)
  • AA407203 protein
  • AL033359 protein
  • ATPTB1 protein
  • HNRNP-I protein
  • HNRNPI protein
  • HNRPI protein
  • polypyrimidine tract-binding protein 1 protein
  • pPTB protein
  • ptb protein
  • PTB-1 protein
  • PTB-T protein
  • PTB2 protein
  • PTB3 protein
  • PTB4 protein
  • ptbp1 protein
  • Pybp protein
  • Pybp1 protein
  • Pybp2 protein
  • T4P13.16 protein
  • T4P13_16 protein
  • vgrbp60 protein
  • wu:fb99f12 protein
  • zgc:110689 protein

Protein level used designations for PTBP1

polypyrimidine tract binding protein 1 , hnrnp I , hnRNP I-related RNA transport protein VgRBP60 , polypyrimidine tract-binding protein , PTB , polypyrimidine tract-binding protein 1 , 57 kDa RNA-binding protein PPTB-1 , RNA-binding protein , heterogeneous nuclear ribonucleoprotein I , heterogeneous nuclear ribonucleoprotein polypeptide I , hnRNP I , polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) , pyrimidine binding protein 1 , pyrimidine binding protein 2 , brb , brom bones

399134 Xenopus laevis
302879 Rattus norvegicus
8853259 Naegleria gruberi strain NEG-M
100285404 Zea mays
282018 Bos taurus
5725 Homo sapiens
379861 Xenopus laevis
485097 Canis lupus familiaris
397461 Sus scrofa
19205 Mus musculus
29497 Rattus norvegicus
323490 Danio rerio
821129 Arabidopsis thaliana
420098 Gallus gallus
Selected quality suppliers for PTBP1 Proteins (PTBP1)
Did you look for something else?