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PORCN belongs to the evolutionarily conserved porcupine (Porc) gene family. Additionally we are shipping Porcupine Homolog (Drosophila) Antibodies (14) and Porcupine Homolog (Drosophila) Kits (5) and many more products for this protein.
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Por-mediated lipidation of the S239-equivalent residue is essential for the interaction with, and secretion by, Wls.
stimulates the posttranslational N-glycosylation of wingless in the endoplasmic reticulum
WntD, a recently characterized Drosophila Wnt family member, does not require Porcupine or Wntless/Evi/Sprinter for its secretion or signaling activity
Role of the porcupine gene in the development of the wing imaginal disk of Drosophila melanogaster
Inhibition of Wnt (show WNT2 Proteins) signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers
three distinct members [porcupine (PORCN), hedgehog (show SHH Proteins) (Hh) acyltransferase (HHAT (show HHAT Proteins)) and ghrelin O-acyltransferase (GOAT)] have been shown to acylate specific proteins or peptides.
porcupine-mediated production of Wnts is context dependent and is not required for all Wnts production, suggesting that alternative mechanisms exist for Wnts production.
We describe the first case of non-mosaic males affected with syndromic microphthalmia because of a non-synonymous variant in the PORCN gene.
the Wnt (show WNT2 Proteins) amino acid residues required for recognition and palmitoylation by PORCN
We describe the ophthalmologic findings in an 18-month-old boy with mosaicism of a novel mutation in PORCN.
a novel variant in the PORCN gene (c.1250T>C:p.F417S) in the focal dermal hypoplasia with spinal anomaly
We report a typical focal dermal hypoplasia (FDH (show ADH5 Proteins)) patient with a recurrent PORCN mutation, which was previously identified, and a second female, with an almost unilateral FDH (show ADH5 Proteins) and a novel postzygotic PORCN mutation.
To the best of our knowledge, this is the second case report that reveals a mutation of the PORCN gene in a patient with almost unilateral focal dermal hypoplasia.
PORCN protein thus appears to moonlight in a novel signaling pathway that is rate-limiting for cancer cell growth and tumorigenesis independent of its enzymatic function in Wnt (show WNT2 Proteins) biosynthesis and secretion
Porcupine-dependent Wnt (show WNT2 Proteins) signaling, unlike previously reported, is dispensable for postnatal gland formation but is required for post-pubertal gland maintenance as well as for stromal cell proliferation.
Overexpression of PORCN enhances the ability of WLS (show WLS Proteins) to promote WNT1 (show WNT1 Proteins) trafficking to the cell surface as well as secretion, but decreases the ability of WLS (show WLS Proteins) to activate WNT1 (show WNT1 Proteins) signaling in target cell.
Inhibition of porcupine abrogates kidney fibrosis not only by overcoming the redundancy of individual Wnt (show WNT2 Proteins) isoforms but also by preventing upstream cytokine-induced Wnt (show WNT2 Proteins) generation.
Conditional PORCN knockout mice exhibit specific changes in AMPAR expression and gating that reduce basal synaptic transmission but leave long-term potentiation intact.
Porcn is required in both extraocular and neuroectodermal tissues to regulate distinct Wnt (show WNT2 Proteins)-dependent processes during morphogenesis of the posterior and anterior segments of the eye
Residues in predicted transmembrane domain 9 within Porcupine are essential for palmitoleoylation.
Data show bronchopneumonia, rhinitis, and otitis media, suggesting a potential link between Porcn function and the normal development of ciliated cells.
Studies highlight the importance of Wnt3 (show WNT3 Proteins) and Wnt7b (show WNT7B Proteins) for embryonic and placental development but suggest that endogenous Porcn-dependent Wnt (show WNT2 Proteins) secretion does not play an essential role in either implantation or blastocyst lineage specification.
an essential regulatory role of PORCN in shaping Wnt (show WNT2 Proteins) signaling gradients.
Porcn inactivation in the mouse produces a model for human FDH (show ADH5 Proteins) and that phenotypic features result from defective WNT (show WNT2 Proteins) signaling in ectodermal- and mesenchymal-derived structures.
This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the Porc family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
, probable protein-cysteine N-palmitoyltransferase porcupine
, protein-cysteine N-palmitoyltransferase porcupine
, porcupine homolog