Prostaglandin E Receptor 1 (Subtype EP1), 42kDa Proteins (PTGER1)

The protein encoded by PTGER1 is a member of the G protein-coupled receptor family. Additionally we are shipping Prostaglandin E Receptor 1 (Subtype EP1), 42kDa Antibodies (62) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTGER1 19216 P35375
Rat PTGER1 PTGER1 25637 P70597
PTGER1 5731 P34995
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Top Prostaglandin E Receptor 1 (Subtype EP1), 42kDa Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days

PTGER1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Prostaglandin E Receptor 1 (Subtype EP1), 42kDa (PTGER1) Interaction Partners

Mouse (Murine) Prostaglandin E Receptor 1 (Subtype EP1), 42kDa (PTGER1) interaction partners

  1. Our study identifies the EP1 signaling pathway as an important link between neuroinflammation and MMP-mediated BBB breakdown in ischemic stroke.

  2. EP1-/- mice maintain increased bone mineral density and stronger cortical and trabecular bone biomechanical properties with aging. The EP1 receptor acts to inhibit bone marrow osteoprogenitor cell differentiation and mineralization.

  3. Results indicate that EP1 receptor activation during seizures, through a protein kinase C pathway, increases probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response

  4. The EP1 receptor facilitates the actions of angiotensin II, thereby suggesting that targeting of both the renin (show REN Proteins)-angiotensin system and the EP1 receptor could be beneficial in diabetic nephropathy.

  5. Propose a mechanism whereby ANG II (show AGT Proteins) increases COX-1 (show PTGS1 Proteins)-derived PGE2 through the AT1R (show AGTRAP Proteins)/PLA2 (show PLA2G2A Proteins) pathway, which promotes ROS (show ROS1 Proteins) production by EP1R/Nox2 (show CYBB Proteins) signaling in the subfornical organ.

  6. dietary administration and direct injection of the EP1 receptor-specific antagonist, ONO-8713, effectively reduced the growth of established CT26 (show DDX53 Proteins) tumors in BALB/c mice

  7. EP1 deletion protects mice from asymmetrical Parkinsonism. The PGE2 EP1 receptor is implicated in 6-OHDA-induced Parkinsonism.

  8. Data suggest that EP1 receptor blockade may be a viable target for antihypertensive therapy.

  9. data suggest that the tumor promoting/progressing effects of EP1 require the PGE2 synthesized by COX-2

  10. Peripheral EP1 receptors contribute significantly to inflammation induced heat pain sensitization while evidence for a contribution to central sensitization was not obtained.

Human Prostaglandin E Receptor 1 (Subtype EP1), 42kDa (PTGER1) interaction partners

  1. COX-2 expression appears to be linked to early hepatocellular carcinoma events (initiation), while EP1 receptor expression may participate in tumor progression and predict survival

  2. Copy number variation in PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema

  3. suppression of EP1 prevented RAMA-induced FasL (show FASL Proteins) suppression in CLT85 cells at both the mRNA and protein levels

  4. A transient interaction between COX-2 and EP1 constitutes a feedback loop whereby an increase in COX-2 expression elevates EP1.

  5. NF-kappaB (show NFKB1 Proteins) inhibitor suppressed 17-PT-PGE2-mediated FoxC2 (show FOXC2 Proteins) upregulation. Immunohistochemistry showed p65 (show GORASP1 Proteins), FoxC2 (show FOXC2 Proteins), EP1 receptor and beta1-integrin were all highly expressed in the HCC (show FAM126A Proteins) cases

  6. COX-1, H446K' is significantly more sensitive to downregulation by EP . Together these data suggest that distinctive ubiquitination of COX-1 and COX-2 may be responsible for their different sensitivity to EP -mediated degradation.

  7. through complex formation with D1, EP1 signaling directs the D1 receptor through G(betagamma) to be coupled to AC7 (show Adcy7 Proteins).

  8. PGE2-enhanced MMP2 (show MMP2 Proteins) expression is mediated through EP1 receptors and calcium signaling pathway-induced CREB (show CREB1 Proteins) phosphorylation in human cholangiocarcinoma cells.

  9. Our study suggests that the PGE (show LIPF Proteins) EP1 receptor regulates FAK (show PTK2 Proteins) phosphorylation by activating the PKC (show PRRT2 Proteins)/c-Src (show SRC Proteins) and EGFR (show EGFR Proteins) signal pathways, which may coordinately regulate adhesion and migration in HCC (show FAM126A Proteins)

  10. PGE (show LIPF Proteins)(2) -mediated NF-kappaB (show NFKB1 Proteins) activation by simultaneous stimulation of EP(1) and EP(4 (show PTGER4 Proteins)) receptors induces maximal IL-8 (show IL8 Proteins) promoter activation and IL-8 (show IL8 Proteins) mRNA and protein induction

Prostaglandin E Receptor 1 (Subtype EP1), 42kDa (PTGER1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.

Gene names and symbols associated with PTGER1

  • prostaglandin E receptor 1 (subtype EP1), 42kDa (PTGER1)
  • prostaglandin E receptor 1 (subtype EP1) (Ptger1)
  • prostaglandin E2 receptor EP1 subtype-like (LOC100855637)
  • 42kDa protein
  • EP1 protein
  • PTGER1 protein
  • Ptgerep1 protein

Protein level used designations for PTGER1

prostaglandin E receptor 1 (subtype EP1), 42kDa , prostaglandin E2 receptor subtype EP1 , PGE receptor EP1 subtype , PGE2 receptor EP1 subtype , prostaglandin E2 receptor EP1 subtype , prostanoid EP1 receptor , EP1 prostanoid receptor , PGE receptor, EP1 subtype , prostaglandin E receptor EP1 subtype , prostaglandin E receptor 1, subtype EP1

747643 Pan troglodytes
100008680 Oryctolagus cuniculus
19216 Mus musculus
25637 Rattus norvegicus
5731 Homo sapiens
610774 Canis lupus familiaris
100855637 Canis lupus familiaris
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