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Protease, serine, 1 (Trypsin 1) Proteins (PRSS1)

PRSS1 encodes a trypsinogen, which is a member of the trypsin family of serine proteases. Additionally we are shipping Protease, serine, 1 (Trypsin 1) Antibodies (74) and Protease, serine, 1 (Trypsin 1) Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRSS1 5644 P07477
Mouse PRSS1 PRSS1 114228  
PRSS1 24691 P00762
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Top Protease, serine, 1 (Trypsin 1) Proteins at

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Rat His-SUMO Tag 50 μg Log in to see 21 to 26 Days
Yeast Rat His tag 50 μg Log in to see 31 to 36 Days
HOST_Mammalian Cells Human His tag,Fc Tag   50 μg Log in to see 5 Days
HOST_Human Human Fc Tag,His tag   10 μg Log in to see 11 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
Yeast Rat His tag   500 μg Log in to see 56 to 66 Days
Yeast REACT_Atlantic Salmon His tag   1 mg Log in to see 56 to 66 Days
Yeast Gadus morhua His tag   1 mg Log in to see 56 to 66 Days

PRSS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus) ,

More Proteins for Protease, serine, 1 (Trypsin 1) (PRSS1) Interaction Partners

Human Protease, serine, 1 (Trypsin 1) (PRSS1) interaction partners

  1. Three types of pathogenic PRSS1 variants was identified in 11 patients, including p.N29I (n=1), p.R122H (n=1), and p.G208A (n=9).

  2. Mutations were found at the promoter and exon 3 of the PRSS1 in patients with pancreatic cancer. That is, five patients had c.410 C > T mutation causing p.Thr 137 Met, and three patients had c. -338 T >G mutation at the promoter of the PRSS1. In patients with PRSS1 mutations, serum trypsin was significantly higher than that in normal controls

  3. These findings suggest that IL-1beta plays a key role in trypsin upregulation and has a pathological role in multiple organ failure in influenza virus infection.

  4. Human anionic trypsinogen is controlled by CTRC in a manner that individual natural mutations are unlikely to increase stability enough to promote intra-pancreatic activation.

  5. Association of PRSS1 polymorphism with idiopathic recurrent acute pancreatitis and idiopathic chronic pancreatitis.

  6. Letter/Case Report: high penetrance of the PRSS1 A16V mutation caused by SPINK1 (show SPINK1 Proteins) N34S and CFTR (show CFTR Proteins) TG11-5T co-mutations associated with pancreatitis.

  7. We did not find PRSS1 mutation in any patient.

  8. In Israel, pediatric as well as adult recurrent acute pancreatitis and chronic pancreatitis are often associated with PRSS1, serine protease inhibitor Kazal type 1 (show SPINK1 Proteins), chymotrypsin C, or Cystic Fibrosis Transmembrane Conductance Regulator (show CFTR Proteins) mutations.

  9. This study shows that PRSS1, SPINK1 (show SPINK1 Proteins) and CFTR (show CFTR Proteins) mutations do not play a role in alcoholic and idiopathic chronic pancreatitis patients.

  10. Recombination events between members of the trypsinogen family can generate high-risk PRSS1 alleles.

Mouse (Murine) Protease, serine, 1 (Trypsin 1) (PRSS1) interaction partners

  1. IL-29 (show IL29 Proteins) can regulate expression of protease activated receptors and tryptase (show TPSAB1 Proteins)- and trypsin-induced IL-4 (show IL4 Proteins) production in mast cells.

  2. Results suggest that regulation of Prss1 and Spink3 expression is involved in the susceptibility to experimentally induced pancreatitis.

  3. The experimental results are consistent with our hypothesis, suggesting that K(+) induced ion-exchanges play a critical role in the initiation of trypsin premature activation in ZGs.

Protease, serine, 1 (Trypsin 1) (PRSS1) Protein Profile

Protein Summary

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.

Gene names and symbols associated with PRSS1

  • trypsin-1 (CpipJ_CPIJ000708)
  • trypsin-1 (CpipJ_CPIJ007079)
  • trypsin-1 (CpipJ_CPIJ007080)
  • trypsin-1 (CpipJ_CPIJ012156)
  • trypsin-1 (CpipJ_CPIJ016225)
  • trypsin-1 (CpipJ_CPIJ016619)
  • trypsin-1 (CpipJ_CPIJ018339)
  • Trypsin-1 (DvirTry1)
  • trypsin-1 (prss1)
  • trypsin I (trp-i)
  • protease, serine, 1 (trypsin 1) (PRSS1)
  • protease, serine, 1 (trypsin 1) (Prss1)
  • serine protease 58-like (LOC615237)
  • trypsin IA (trp-ia)
  • DvirGJ21500 protein
  • dvir_GLEANR_6853 protein
  • Dvtry-1 protein
  • GJ21500 protein
  • PRSS1 protein
  • PTRYI protein
  • RATPTRYI protein
  • TRP1 protein
  • Try-1 protein
  • TRY1 protein
  • TRY4 protein
  • Trygn16 protein
  • TRYP1 protein
  • Trypsin-1 protein

Protein level used designations for PRSS1

trypsin-1 , DvirGJ21500-PA , DvirTry1-PA , GJ21500-PA , Try1-PA , Trypsin-1 , beta-trypsin , cationic trypsinogen , digestive zymogen , nonfunctional trypsin 1 , trypsinogen 1 , trypsinogen A , protease, serine, 1 , trypsin 1 , trypsinogen 16 , anionic trypsin I , anionic trypsin-1 , pancreatic trypsin 1 , pretrypsinogen I , protease, serine, 2 , serine protease 1 , protease, serine, 1 (trypsin 1) , trypsin X3

6031472 Culex quinquefasciatus
6038909 Culex quinquefasciatus
6038910 Culex quinquefasciatus
6045392 Culex quinquefasciatus
6050001 Culex quinquefasciatus
6050189 Culex quinquefasciatus
6052295 Culex quinquefasciatus
6625436 Drosophila virilis
100127756 Xenopus (Silurana) tropicalis
100137021 Salmo salar
5644 Homo sapiens
114228 Mus musculus
24691 Rattus norvegicus
615237 Bos taurus
100137022 Salmo salar
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