Protease, serine, 16 (Thymus) Proteins (PRSS16)

PRSS16 encodes a serine protease expressed exclusively in the thymus. Additionally we are shipping PRSS16 Antibodies (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRSS16 10279 Q9NQE7
PRSS16 54373 Q9QXE5
Rat PRSS16 PRSS16 364719  
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Top PRSS16 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

PRSS16 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Protease, serine, 16 (Thymus) (PRSS16) Interaction Partners

Human Protease, serine, 16 (Thymus) (PRSS16) interaction partners

  1. The genes HIST1H2BJ, PRSS16, and PGBD1 (show PGBD1 Proteins) were not associated with Japanese patients with schizophrenia.

  2. ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT (show COMT Proteins), PDE4B (show PDE4B Proteins), and DRD2 (show DRD2 Proteins)

  3. The gene encoding thymus-specific serine protease (PRSS16) maps to the extended HLA complex, which harbours several genes predisposing for autoimmune diseases.

  4. data suggest that it is unlikely that polymorphisms within the PRSS16 gene are involved in the predisposition to diabetes type 1

  5. our results identify PRSS16 and BTN3A2 (show BTN3A2 Proteins), two genes thought to play important roles in regulating the immune response, as potentially novel susceptibility genes for Type I diabetes.

Mouse (Murine) Protease, serine, 16 (Thymus) (PRSS16) interaction partners

  1. Data indicate that T-cell receptors that react to chromogranin A (ChgA (show CHGA Proteins)) and islet amyloid polypeptide (show IAPP Proteins) precursor (IAPP (show IAPP Proteins)) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP).

  2. our data demonstrate that antitumoral immune surveillance requires thymic TSSP-driven production of CD4 (show CD4 Proteins)(+) T cells contributing to inflammatory balance.

  3. The differential thymic expression of 4,500 mRNAs of wild-type (WT) C57BL/6 mice with their respective Prss16-knockout (KO) mutants by using microarrays, was analyzed.

  4. Tssp is a critical regulator of diabetes development through the selection of the autoreactive CD4 (show CD4 Proteins) T cell repertoire

  5. suggesting that TSSP is necessary for the intrathymic development of cells expressing these T cell receptors

  6. role of Prss16 in T-cell development and susceptibility to autoimmunity in the mouse

  7. Data suggest that Prss16 is not required for quantitatively normal T-cell development.

  8. Prss16 is involved in the positive selection of some CD4(+) T lymphocytes and likely constitutes the first serine protease to play a function in the intrathymic presentation of self-peptides bound to MHC class II complexes.

PRSS16 Protein Profile

Protein Summary

This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.

Gene names and symbols associated with PRSS16

  • protease, serine, 16 (thymus) (PRSS16)
  • protease, serine, 16 (thymus) (prss16)
  • protease, serine, 16 (thymus) (Prss16)
  • AI448615 protein
  • TSSP protein

Protein level used designations for PRSS16

protease, serine, 16 (thymus) , thymus-specific serine protease , serine protease 16 , thymus specific serine peptidase

462502 Pan troglodytes
488292 Canis lupus familiaris
495469 Xenopus laevis
614489 Bos taurus
702060 Macaca mulatta
100124847 Xenopus (Silurana) tropicalis
100352361 Oryctolagus cuniculus
100385909 Callithrix jacchus
100457691 Pongo abelii
100471221 Ailuropoda melanoleuca
100589645 Nomascus leucogenys
100628128 Sus scrofa
10279 Homo sapiens
54373 Mus musculus
364719 Rattus norvegicus
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