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PRSS16 encodes a serine protease expressed exclusively in the thymus. Additionally we are shipping PRSS16 Antibodies (28) and many more products for this protein.
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The genes HIST1H2BJ, PRSS16, and PGBD1 (show PGBD1 Proteins) were not associated with Japanese patients with schizophrenia.
ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT (show COMT Proteins), PDE4B (show PDE4B Proteins), and DRD2 (show DRD2 Proteins)
The gene encoding thymus-specific serine protease (PRSS16) maps to the extended HLA complex, which harbours several genes predisposing for autoimmune diseases.
data suggest that it is unlikely that polymorphisms within the PRSS16 gene are involved in the predisposition to diabetes type 1
our results identify PRSS16 and BTN3A2 (show BTN3A2 Proteins), two genes thought to play important roles in regulating the immune response, as potentially novel susceptibility genes for Type I diabetes.
Data indicate that T-cell receptors that react to chromogranin A (ChgA (show CHGA Proteins)) and islet amyloid polypeptide (show IAPP Proteins) precursor (IAPP (show IAPP Proteins)) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP).
our data demonstrate that antitumoral immune surveillance requires thymic TSSP-driven production of CD4 (show CD4 Proteins)(+) T cells contributing to inflammatory balance.
The differential thymic expression of 4,500 mRNAs of wild-type (WT) C57BL/6 mice with their respective Prss16-knockout (KO) mutants by using microarrays, was analyzed.
Tssp is a critical regulator of diabetes development through the selection of the autoreactive CD4 (show CD4 Proteins) T cell repertoire
suggesting that TSSP is necessary for the intrathymic development of cells expressing these T cell receptors
role of Prss16 in T-cell development and susceptibility to autoimmunity in the mouse
Data suggest that Prss16 is not required for quantitatively normal T-cell development.
Prss16 is involved in the positive selection of some CD4(+) T lymphocytes and likely constitutes the first serine protease to play a function in the intrathymic presentation of self-peptides bound to MHC class II complexes.
This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.
protease, serine, 16 (thymus)
, thymus-specific serine protease
, serine protease 16
, thymus specific serine peptidase