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Protein tyrosine Phosphatase, Receptor Type, C Proteins (PTPRC)

The protein encoded by PTPRC is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping CD45 Antibodies (1822) and CD45 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTPRC 5788 P08575
PTPRC 19264  
PTPRC 24699 P04157
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Top CD45 Proteins at

Showing 10 out of 32 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 69 to 74 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 69 to 74 Days
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
HOST_Baculovirus infected Insect Cells Mouse His tag,GST tag 100 μg Log in to see 16 Days
HOST_HEK-293 Cells Human Un-conjugated   10 μg Log in to see 2 to 3 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

PTPRC Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, , , ,
Mouse (Murine) , , ,
, , , , ,
Rat (Rattus)

Top referenced CD45 Proteins

  1. Human CD45 Protein expressed in Human Cells - ABIN2002039 : Justement, Campbell, Chien, Cambier: Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. in Science (New York, N.Y.) 1991 (PubMed)
    Show all 6 references for ABIN2002039

More Proteins for Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) Interaction Partners

Human Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) interaction partners

  1. CD45RO+ memory T-cells produce IL-17 (show IL17A Proteins) in patients with atherosclerosis.

  2. Data show the structural basis for, and the potent signaling effects of, local CD45 antigen and kinase segregation.

  3. a CD45+/CD19 (show CD19 Proteins) - cell population in bone marrow aspirates correlated with the clinical outcome of patients with mantle cell lymphoma.

  4. High CD45 expression is associated with multiple myeloma.

  5. C77G T(reg (show EXTL3 Proteins)) showed diminished upregulation of activation markers, lower phosphorylation of p56(lck (show LCK Proteins))(Y505) and a reduced proliferative potential when stimulated with anti-TcR or anti-TcR plus CD28 (show CD28 Proteins) mAb suggesting decreased responsiveness to activating stimuli. Data suggest that the changes in CD45 isoform combination resulting from the C77G mutation alter the responsiveness

  6. Findings indicate that CD45 antigen(+) and c-Kit protein(+) hematopoietic cells were more abundant in muscle than in bone marrow between embryonic 14.5 and 17.5 days.

  7. CD4 (show CD4 Proteins)+CD45RO+CD25 (show IL2RA Proteins)-/lowCD127+: CD4 (show CD4 Proteins)+CD45RO+CD25hiCD127-/low ratio in peripheral blood indicates heart transplant recipients at risk for cardiac allograft vasculopathy.

  8. CD45+ cells were abundant in the stroma of physiologically immature placental villi and decreased as pregnancy progressed.

  9. This study demonstrated that the copy number variations of PTPRC relate to opioid dependence.

  10. This study did not replicate the association between PTPRC and the response to anti-TNF (show TNF Proteins) treatment in our Southern European population. We found that TRAF1 (show TRAF1 Proteins)/C5 risk RA variants potentially influence anti-TNF (show TNF Proteins) treatment response.

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) interaction partners

  1. deletion of Pten in CD45-expressing cells induces development of T-cell acute lymphoblastic leukemia and lymphoma, but not other hematologic malignancies

  2. A noncatalytic role for CD45 in regulating tonic, but not antigen-mediated, B-cell antigen receptor (BCR (show BCR Proteins)) signaling through modulation of the function of the inhibitory coreceptor CD22 (show CD22 Proteins), was identified.

  3. CD45 ligation specifically reduced Treg motility in an integrin-dependent manner, resulting in enhanced interactions between Tregs and DCs in vivo.

  4. Data (including data from genome-wide mutagenesis studies) suggest that nonsense mutation in Ptprc is a susceptibility trait for herpes simplex encephalitis due to Herpesvirus 1; this effect appears to be mediated by Th1 (show HAND1 Proteins) cells and the brain stem.

  5. These findings demonstrate a novel role for CD45 on innate immune cells in promoting lymphopenia-induced T cell proliferation and suggest that innate immune cells may communicate with stromal cells to regulate IL-7 (show IL7 Proteins) production.

  6. Expressing CD45 promoters containing these regions and tethered to green fluorescent protein (GFP) in a primary B-cell differentiation assay and a transplantation model resulted in high levels of GFP in lymphoid, myeloid, and nucleated erythroid cells

  7. identified a novel CD45 phosphorylation event in hematopoietic progenitor cells that correlated with motile response and governed by the chemotactic factor CXCL12 (show CXCL12 Proteins)

  8. Data indicate that CD45 functions to regulate Pyk2 (show PTK2B Proteins)/FAK (show PTK2 Proteins) activity, likely through the activity of Src (show SRC Proteins) family kinases, which in turn regulates the levels of paxillin (show PXN Proteins) to modulate macrophage adhesion and migration.

  9. The large ectodomains of CD45 and CD148 modulate their inhibitory effect by enabling their passive, size-based segregation from ligated TCR, supporting the kinetic-segregation model of TCR triggering.

  10. Data indicate that sox13 (show SOX13 Proteins)-mutant CD45.1(+) congenic mice were protected from psoriasis-like skin changes, which identified a role for Sox13 (show SOX13 Proteins)-dependent gammadeltaT17 cells in the inflammatory condition.

CD45 (PTPRC) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Gene names and symbols associated with PTPRC

  • protein tyrosine phosphatase, receptor type, C (PTPRC)
  • protein tyrosine phosphatase, receptor type, C (ptprc)
  • protein tyrosine phosphatase, receptor type, C (Ptprc)
  • B220 protein
  • cd45 protein
  • CD45R protein
  • GP180 protein
  • L-CA protein
  • Lca protein
  • loc protein
  • Ly-5 protein
  • LY5 protein
  • Lyt-4 protein
  • PTPRC protein
  • RT7 protein
  • si:dkeyp-47c5.1 protein
  • T200 protein

Protein level used designations for PTPRC

receptor-type tyrosine-protein phosphatase C , leukocyte common antigen, CD45 , protein tyrosine phosphatase, receptor type, C , CD45 antigen , leukocyte common antigen , receptor-type tyrosine-protein phosphatase C-like , T200 glycoprotein , T200 leukocyte common antigen , protein tyrosine phosphatase, receptor type, c polypeptide , lymphocyte antigen 5 , lymphocyte common antigen , Protein tyrosine phosphatase, receptor-type, c polypeptide , leucocyte common antigen , leukocyte common antigen A , leukocyte common antigen B , membrane tyrosine phosphatase

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100546661 Meleagris gallopavo
5788 Homo sapiens
19264 Mus musculus
24699 Rattus norvegicus
407152 Bos taurus
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