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PCDH10 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. Additionally we are shipping PCDH10 Antibodies (28) and PCDH10 Kits (1) and many more products for this protein.
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Results suggest that protocadherin 10 (PCDH10)-Dishevelled, EGL-10 and Pleckstrin domain containing 1 (DEPDC1)-caspase signaling may be a novel regulatory axis in endometrial endometrioid carcinoma (EEC) development.
Data show that protocadherin 10 (PCDH10) over-expression could significantly induce cell apoptosis, and restrain proliferation, invasion and migration ability of BXPC-3 pancreatic cancer cells.
Our present findings suggested that the hypermethylated CpG site counts of PCDH10 DNA promoter for evaluating the prognosis of GC was reasonable by using the D-BGS
PCDH10 methylation is a potential biomarker that predicts a poor prognosis after curative resection of pathological stage I non-small-cell lung cancer.
PCDH10 antagonized MM cell proliferation via the downregulation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)/BCL-9 (show BCL9 Proteins) signaling, whereas PCDH10 repressed the expression of AKT (show AKT1 Proteins) to promote the expression of GSK3beta and then to restrain the activation of beta-catenin (show CTNNB1 Proteins)
These results suggest an important role of p53 in regulating tumor cell migration through activating PCDH10 expression.
Aberrant methylation of PCDH10 predicts worse biochemical recurrence-free survival in patients with prostate cancer after radical prostatectomy.
Gastric cancer patients with 5 or more methylated CpG sites of PCDH10 promoter had significantly poorer survival.
Findings establish a novel PCDH10-Wnt/beta-catenin-MALAT1 regulatory axis that contributes to EEC development.
These results indicate that promoter methylation status of PCDH10, SPARC (show SPARC Proteins), and UCHL1 (show UCHL1 Proteins) may be used both as prognostic and predictive molecular marker for colorectal cancer patients
Pcdh10, which is regulated by Pou3f1 (show POU3F1 Proteins) and Hoxa5 (show HOXA5 Proteins), is a mediator of like-like clustering of motor neuron cell bodies in the developing phrenic nerve.
results show that OL-pc is essential for both elongation of striatal axons and patterning of the putative guidance cues for thalamocortical projections.
The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation.
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains.
ortholog of OL-pcdh