Pseudopodium-Enriched Atypical Kinase 1 Proteins (PEAK1)

Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. Additionally we are shipping PEAK1 Antibodies (52) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PEAK1 79834 Q9H792
Mouse PEAK1 PEAK1 244895 Q69Z38
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Top PEAK1 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
Insect Cells Human GST tag   10 μg Log in to see 3 to 4 Days

PEAK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for Pseudopodium-Enriched Atypical Kinase 1 (PEAK1) Interaction Partners

Human Pseudopodium-Enriched Atypical Kinase 1 (PEAK1) interaction partners

  1. the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9.

  2. Findings indicate that eIF5A (show EIF5 Proteins)-PEAK1-YAP (show YAP1 Proteins) signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity.

  3. report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta (show TGFB1 Proteins) receptors and integrin/Src (show SRC Proteins)/MAPK (show MAPK1 Proteins) pathways and that PEAK1 is an important molecular regulator of TGFbeta (show TGFB1 Proteins)-induced tumor progression and metastasis in breast cancer

  4. this regard, we have demonstrated that PEAK1 is necessary for TGFbeta (show TGFB1 Proteins) to induce ZEB1-mediated EMT (show ITK Proteins) in the context of fibronectin (show FN1 Proteins)/ITGB3 (show ITGB3 Proteins) activation.

  5. Suggest that loss of PEAK1/E-cadherin (show CDH1 Proteins) may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition.

  6. eIF5A (show EIF5 Proteins) proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis.

  7. results define a novel signaling pathway in basal breast cancer involving Lyn (show LYN Proteins) and SgK269 that offers clinical opportunities for therapeutic intervention

  8. phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover

  9. Here, we report that the novel tyrosine kinase (show TXK Proteins) PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN).

  10. Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms

PEAK1 Protein Profile

Protein Summary

Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN (By similarity).

Gene names and symbols associated with PEAK1

  • NKF3 kinase family member (PEAK1)
  • RIKEN cDNA C230081A13 gene (C230081A13Rik)
  • 1110049L02Rik protein
  • 9530046P14 protein
  • AA690169 protein
  • BE132841 protein
  • mKIAA2002 protein
  • Peak1 protein
  • SGK269 protein

Protein level used designations for PEAK1

pseudopodium enriched atypical kinase , pseudopodium-enriched atypical kinase 1 , sugen kinase 269 , tyrosine-protein kinase SgK269 , NKF3 kinase family member

79834 Homo sapiens
244895 Mus musculus
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