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The product of P2RX7 belongs to the family of purinoceptors for ATP. Additionally we are shipping P2RX7 Antibodies (116) and P2RX7 Proteins (7) and many more products for this protein.
Showing 5 out of 12 products:
Blockade of the P2X7 receptor reduces cyst formation via ERK (show MAPK1 ELISA Kits)-dependent pathways in a zebrafish model of polycystic kidney disease.
these data indicate that activation of EGFR (show EGFR ELISA Kits) enhanced the expression of P2X7R in neuroblastoma (show ARHGEF16 ELISA Kits) cells lacking trophic support, being PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/PKC signaling pathway and Sp1 (show PSG1 ELISA Kits) mediating this pro-survival outcome
Result suggest the positive correlation between purinergic receptor P2X 7 (P2X7R) and T-complex protein 1 (TCP-1) in lymphoma patients.
A gain-of-function mutation in P2X7R associated with autoimmune disease caused enhanced TG2 (show TGM2 ELISA Kits) externalization from cells, and this correlated with increased pore activity.
pancreatic ductal adenocarcinoma cell lines overexpress P2X7R and the receptor plays crucial roles in cell survival, migration and invasion.
P2X7 SNPs, 1513A>C and -762T>C, may be associated with the susceptibility to tuberculosis.
Report association between elevated expression of P2X7 receptor in monocytes and high serum CRP (show CRP ELISA Kits) and cytokine levels in type 2 diabetics.
The altered function and expression of P2X7 and ART1 (show ART1 ELISA Kits) in the human CD39 (show ENTPD1 ELISA Kits)+ Treg or CD39 (show ENTPD1 ELISA Kits)- Treg cells could participate in the resistance against cell death induced by ATP or NAD.
signaling through purinergic receptors, particularly P2X7R, drives an adaptive Th17 response in human visceral adipose tissue underlying the metabolic changes in obesity.
This chapter describes structural features of P2X7, chemical properties of its agonist, antagonist, and allosteric modulators and summarizes recent advances on P2X7 receptor as therapeutic target in the aforementioned diseases
High P2X7R expression is a good prognostic factor for glioma radiosensitivity and survival probability in humans.
For the inflammasome-dependent IL-1beta (show IL1B ELISA Kits) release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta (show IL1B ELISA Kits) release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor.
Activation of P2X7 by ATP induced the release of TNFalpha (show TNF ELISA Kits) from microglia which protected neurons from NMDA-induced excitotoxicity, might also account for neuroprotective properties of valproic acid
Data provide mechanistic insights into the role of KHG26792 in the inhibition of TNF-alpha (show TNF ELISA Kits) produced via purinergic receptor P2X7 receptor-mediated activation of NFAT (show NFATC1 ELISA Kits) and MAPK (show MAPK1 ELISA Kits) pathways in adenosine triphosphate-treated BV-2 cells.
Results suggest that P2X7R is an important activator of the immune response that leads to type 1 diabetes.
P2X7R plays a role in the neuroinflammation in a model of mania.
Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (P2X7R) and plays a role in lymphoid neoplasm metastasis.
IL-17 (show IL17A ELISA Kits) production in the hearts of M2AChR mice is dependent on P2x7 expression in dilated cardiomyopathy.
unveiled the critical role of adenosine triphosphate-P2X7 receptor (ATP-P2X7R)in brain damage in radiation-induced brain injury (RBI), suggesting that inhibition of ATP-P2X7R axis might be a potential strategy for the treatment of patients with RBI.
High P2X7R expression is a good prognostic factor for glioma radiosensitivity and survival probability.
P2X7 is a protective factor and therapeutic target for the amelioration of hyperoxia-induced lung injury.
Neutrophils express functional cell-surface P2X7R, which leads to ATP-induced loss of intracellular K(+), NLRP3 (show NLRP3 ELISA Kits) inflammasome activation and IL-1beta (show IL1B ELISA Kits) secretion.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
P2X purinoceptor 7
, purinergic receptor P2X, ligand-gated ion channel, 7
, p2X purinoceptor 7-like
, ATP receptor
, P2X7 receptor
, P2Z receptor
, purinergic receptor P2X7 variant A
, P2X7 purinoceptor
, purinergic receptor P2X7