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The product of P2RY12 belongs to the family of G-protein coupled receptors. Additionally we are shipping P2RY12 Antibodies (34) and P2RY12 Proteins (4) and many more products for this protein.
Showing 10 out of 24 products:
Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/P2Y13 (show P2RY13 ELISA Kits) receptors among BV-2 microglia.
findings not only revealed the critical role of P2Y12 in Th17 differentiation and EAE pathogenesis, but also suggested the promising potential of P2Y12 antagonists in the treatment of autoimmune diseases
P2y12 Receptor Promotes Pressure Overload-Induced Cardiac Remodeling via Platelet-Driven Inflammation in Mice.
In P2Y12(-/-) mice, the growth of syngeneic ovarian cancer tumors was reduced by >85% compared with wild-type (WT) mice. In contrast, there was no difference in tumor growth between P2Y1 (show P2RY1 ELISA Kits)(-/-) and WT mice.
Vessel wall P2Y12 receptor, which promotes VSMCs migration through cofilin (show CFL1 ELISA Kits) dephosphorylation, plays a critical role in the development of atherosclerotic lesions.
P2Y12 null mice are refractory to sepsis-induced lung injury, suggesting a key role for activated platelets and the P2Y12 receptor during sepsis.
excessive mechanical stress may induce a sustained release of ADP and promote SMC senescence via P2ry12-dependent sustained Ras activation, thereby contributing to excessive inflammation and degeneration, which provides insights into TAAD formation and progression.
AHR (show AHR ELISA Kits) and airway inflammation in a mouse model of asthma. P2Y12 can be a novel therapeutic target to the suppression of eosinophils in asthma.
quinine/bupivacaine-sensitive potassium channels are the functional effectors of the P2Y12R-mediated signaling in microglia activation following neuronal injury
Disrupting P2Y12 alters the microglial response to monocular deprivation and abrogates ocular dominance plasticity.
The results suggest that P2Y12 is a useful marker for the identification of human microglia throughout the lifespan. Moreover, P2Y12 expression might help to discriminate activated microglia and infiltrating myeloid cells from quiescent microglia in the human CNS.
P2RY12, the gene related to thrombogenesis was differentially expressed between the left atrium and right atrium in Sinus rhythm and Atrial fibrillation. Therefore, the changes in the expression of these genes were likely involved in the pathophysiology of AF-related thrombus formation.
Abnormalities of P2Y12 receptor include congenital deficiencies or high activity in diseases like diabetes mellitus and chronic kidney disease, exposing such patients to a prothrombotic condition. (Review)
Data suggest that PAR4 (show PAWR ELISA Kits) and P2Y12 heterodimer internalization/endocytosis is required for beta-arrestin-2 (show ARRB2 ELISA Kits) recruitment to endosomes and up-regulation of Akt (show AKT1 ELISA Kits) signaling; activation of PAR4 (show PAWR ELISA Kits) but not of P2Y12 drives internalization of the PAR4 (show PAWR ELISA Kits)-P2Y12 heterodimer. (PAR4 (show PAWR ELISA Kits) = protease-activated receptor 4 (show F2RL3 ELISA Kits); P2Y12 = purinergic receptor P2Y (show P2RY1 ELISA Kits), G-protein coupled, 12 protein; Akt (show AKT1 ELISA Kits) = proto-oncogene (show RAB1A ELISA Kits) protein c (show PROC ELISA Kits)-akt (show AKT1 ELISA Kits))
Studies indicate that purinergic receptor P2Y12 (P2Y12 receptor) gene C34T and G52T polymorphism might be a risk factor for the poor response to the platelet in patients on clopidogrel therapy.
studies describe 2 novel modes of action of ticagrelor, inhibition of platelet ENT1 and inverse agonism at the P2Y12R that contribute to its effective inhibition of platelet activation.
apart from the established association of the CYP2C19 (show CYP2C19 ELISA Kits) *2 and *3 LOF alleles with high on-treatment platelet reactivity (HTPR), haplotypes of P2RY12 rs6798347, rs6787801, rs6801273, and rs6785930 rather than rs2046934 (T744C) that related to pharmacodynamics of clopidogrel in patients with ACS (show PLA2G15 ELISA Kits) were independently associated with HTPR
The present report illustrates an update of dysfunctional platelet P2Y12R mutations diagnosed with congenital lifelong bleeding problems. [review]
aim of this study was to evaluate the effects of platelet receptor gene (P2Y12, P2Y1 (show P2RY1 ELISA Kits)) and glycoprotein gene (GPIIIa (show ITGB3 ELISA Kits)) polymorphisms, as well as their interactions, on antiplatelet drug responsiveness and clinical outcomes in patients with acute MIS (show AMH ELISA Kits)
The Conundrum of Platelet P2Y12 Inhibition in ST-Segment Elevation Myocardial Infarction.
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.
P2Y purinoceptor 12
, ADP-glucose receptor
, G-protein coupled receptor SP1999
, Gi-coupled ADP receptor HORK3
, P2Y12 platelet ADP receptor
, purinergic receptor P2RY12
, putative G-protein coupled receptor