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The protein encoded by RECQL5 is a helicase that is important for genome stability. Additionally we are shipping RECQL5 Antibodies (68) and many more products for this protein.
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RECQ5 removes RAD51 (show RAD51 Proteins) filaments stabilizing stalled replication forks at common fragile sites and hence facilitates CFS cleavage by MUS81 (show MUS81 Proteins)-EME1 (show EME1 Proteins).
the open and closed forms of RECQL5 were used together with a quantitative comparison of all current RecQ family structures to construct a mechanistic model for RECQL5 helicase activity
Study characterized the G-quadruplex (GQ) unfolding activity of RECQ5 for different DNA constructs under different salt conditions, showed that RECQ5 is overall a weak GQ destabilizer compared to Bloom and Werner
interaction between RECQ5 and proliferating cell nuclear antigen (PCNA (show PCNA Proteins)) promotes RAD18 (show RAD18 Proteins)-dependent PCNA (show PCNA Proteins) ubiquitination and the helicase activity of RECQ5 promotes the processing of replication intermediates.
RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins
RECQL5 is a critical regulator of genome stability in myeloproliferative neoplasms and demonstrate that replication stress-associated cytotoxicity can be amplified specifically in JAK2V617F mutant cells through RECQL5-targeted synthetic lethality.
Expression of RECQL5 in breast cancer can drive proliferation supporting an oncogenic function for RECQL5 in breast cancer. RECQL5 is a promising biomarker in breast cancer.
RecQ5 prevents transcription associated genome instability by facilitating PIAS1 (show PIAS1 Proteins)-SRSF1 (show SRSF1 Proteins) ligase complex sumoylation of DNA topoisomerase 1 (show TOP1 Proteins).
results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment
PARylation is involved in the recruitment of RECQL5 and WRN to laser-induced DNA damage and RECQL5 and WRN have differential responses to PARylated PARP1 and Poly(ADP-ribose).
Recql5 protects the liver against LPS (show TLR4 Proteins)/D-Gal (show GAL Proteins)-induced injury by suppressing hepatocyte apoptosis and oxidative stress and modulation of CYP450 expression.
Recql5 has a tumor suppressor role in the gastrointestinal tract of Apc (show APC Proteins)(min) mice.
Recql5-deficient cells exhibit elevated frequencies of spontaneous DNA double-strand breaks and homologous recombination (
Data suggest that Recql5 helps maintain active DNA replication to prevent collapse of replication forks and accumulation of DSBs, preserve genome integrity and prevent cell death after replication stress due to topoisomerase I (show TOP1 Proteins) poisoning.
The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene.
ATP-dependent DNA helicase Q5
, RecQ protein-like 5
, ATP-dependent DNA helicase Q5-like
, DNA helicase, RecQ-like type 5