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Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. Additionally we are shipping RCN1 Antibodies (36) and RCN1 Proteins (10) and many more products for this protein.
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In the adult mice, RCAN1 (show RCAN1 ELISA Kits) was mainly expressed in the neuropil throughout the brain.
irradiated tumor cells were observed to significantly up-regulate the expression of calcium-binding proteins CALM1, CALU (show CALU ELISA Kits), and RCN1 (show RCAN1 ELISA Kits), suggesting important roles for these mediators in promoting tumor cell survival during hypoxia
RCN1 (show RCAN1 ELISA Kits) expression was not statistically significantly different to healthy controls but was associated with disease activity score and could be used as a stratification biomarker for systemic sclerosis patients.
reticulocalbin-1 plays a key role in the development of doxorubicin-associated resistance
Ca(2 (show CA2 ELISA Kits)+) binding caused an increase in the alpha-helix content of human RCN1 (show RCAN1 ELISA Kits). On the other hand, RCN1 (show RCAN1 ELISA Kits) did not change the structure with Mg.
a promising role of RCN1 as a possible marker in Renal cell carcinoma
reticulocalbin-1 may be an important molecule in understanding lymphatic endothelial cells in tumors function and control of lymphatic metastasis.
Increased RCN1 (show RCAN1 ELISA Kits) is associated with systemic sclerosis and nephrogenic systemic fibrosis.
deletion of Rcn1 (show RCAN1 ELISA Kits) directly or indirectly contributes to the eye phenotype in Pax6 (show PAX6 ELISA Kits) contiguous gene deletions
RCN1 (show RCAN1 ELISA Kits) also is expressed on the cell surface of several endothelial cell lines, including human dermal microvascular endothelial cells (HDMVECs), bone marrow endothelial cells (BMEC), and transformed human bone marrow endothelial cells (TrHBMEC).
Data show that calumenin (show CALU ELISA Kits) in the presence of calcium binds specifically to thrombospondin-1 (show THBS1 ELISA Kits), but closely-related reticulocalbin (show CALU ELISA Kits) does not form a similar complex.
Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.
, proliferation-inducing gene 20