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Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) ELISA Kits

The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. Additionally we are shipping RP2 Proteins (1) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat RP2 RP2 367714  
Anti-Human RP2 RP2 6102 O75695
Anti-Mouse RP2 RP2 19889 Q9EPK2
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More ELISA Kits for RP2 Interaction Partners

Zebrafish Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) interaction partners

  1. maternal rp2 mRNA is essential for successful embryonic development and thus contributes to egg developmental competence

  2. Knockout of RP2 decreases GRK1 (show GRK1 ELISA Kits) and rod transducin (show GNAT1 ELISA Kits) subunits and leads to photoreceptor degeneration in zebrafish

  3. Results suggest that RP2 plays a key role in photoreceptor development and maintenance in zebrafish

  4. Zebrafish RP2 is widely expressed throughout development. ZFRP2 knockdown caused retinal degeneration in zebrafish.

Human Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) interaction partners

  1. seven out of 27 families, displaying mutations in the ABCA4 (show ABCA4 ELISA Kits), RP1 (show STK19 ELISA Kits), RP2 and USH2A (show USH2A ELISA Kits) genes, could be genetically or clinically reclassified. These results demonstrate the potential of our panel-based NGS strategy in RP diagnosis

  2. The ability of the restored RP2 protein (show P2RX1 ELISA Kits) level to reverse the observed cellular phenotypes in cells lacking RP2 indicates that translational read-through could be clinically beneficial for patients.

  3. ellipsometric measurements of naRP2 demonstrated that its particular affinity for saturated phospholipids can be explained by its larger extent of insertion in this phospholipid monolayer compared to that in polyunsaturated phospholipid monolayers.

  4. The methylation state of CpG sites close to the RP2 core promoter (GAAA)n repeat serves as a proxy measurement of X-chromosome inactivation in human and non-human primates.

  5. A novel frameshift mutation in RP2 was detected. This mutation was located in exon 2 of the RP2 gene: a nucleotide C was inserted at 111 (c.111insC, Fig. 1A), which caused a protein translation frameshift

  6. Direct sequencing of RPGR (show RPGR ELISA Kits) and RP2 allowed for identification of a disease-causing mutation in 21 families. Of these "adRP (show PLIN2 ELISA Kits)" families 19 had RPGR (show RPGR ELISA Kits) mutations, and two had RP2 mutations.

  7. Based on our findings, we suggest that RPGR (show RPGR ELISA Kits) should be considered as a first tier gene for screening isolated males with retinal degeneration.

  8. data support a role for RP2 in facilitating the membrane association and traffic of Gbeta1, potentially prior to the formation of the obligate Gbeta:Ggamma heterodimer; combined with other recent evidence, this suggests that RP2 may co-operate with Arl3 and its effectors in the cilia-associated traffic of G proteins

  9. The localization of RP2 to basal bodies and cilia in photoreceptors and kidney cells has linked RP2 dysfunction with ciliopathies.

  10. Data demonstrate that Importin (show KPNA4 ELISA Kits) beta2 is necessary for localization of retinitis pigmentosa 2 (RP2) to the primary cilium, and identify two distinct binding sites of RP2, which interact independently with Importin (show KPNA4 ELISA Kits) beta2.

Mouse (Murine) Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) interaction partners

  1. RP2 has a role in cone photoreceptor sensory cilium elongation in mice

  2. we first performed detailed characterization of the Rp2-knockout (Rp2-KO) mice and observed early-onset cone dysfunction

  3. Our studies suggest that RP2 contributes to the maintenance of photoreceptor function and that cone opsin (show RHO ELISA Kits) mislocalization represents an early step in XLRP caused by RP2 mutations.

  4. We propose that RP2 regulation of Arl3 is important for maintaining Golgi cohesion, facilitating the transport and docking of vesicles and thereby carrying proteins to the base of the photoreceptor connecting cilium for transport to the outer segment.

RP2 Antigen Profile

Antigen Summary

The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death

Gene names and symbols associated with RP2

  • retinitis pigmentosa 2 homolog (human) (Rp2) antibody
  • retinitis pigmentosa 2 (X-linked recessive) (RP2) antibody
  • XRP2 protein (Bm1_36735) antibody
  • XRP2-like protein (PITG_13367) antibody
  • XRP2 protein (LOAG_11813) antibody
  • XRP2 protein (LOC100338686) antibody
  • retinitis pigmentosa 2 (X-linked recessive) (rp2) antibody
  • retinitis pigmentosa 2 homolog (human) (Rp2h) antibody
  • AI662636 antibody
  • DELXp11.3 antibody
  • NM23-H10 antibody
  • NME10 antibody
  • RGD1565124 antibody
  • Rp2 antibody
  • Rp2h antibody
  • TBCCD2 antibody
  • wu:fj10e02 antibody
  • wu:fm72d05 antibody
  • XRP2 antibody
  • zfrp2 antibody
  • zgc:55632 antibody

Protein level used designations for RP2

protein XRP2 , retinitis pigmentosa 2 (X-linked recessive) , XRP2 protein , XRP2-like protein , protein XRP2-like , nme10 , retinitis pigmentosa 2 homolog

367714 Rattus norvegicus
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534054 Bos taurus
6102232 Brugia malayi
9474509 Phytophthora infestans T30-4
9949274 Loa loa
100338686 Oryctolagus cuniculus
100468530 Ailuropoda melanoleuca
406755 Danio rerio
491853 Canis lupus familiaris
711227 Macaca mulatta
100060484 Equus caballus
100380020 Xenopus (Silurana) tropicalis
100413670 Callithrix jacchus
100460005 Pongo abelii
100622983 Sus scrofa
6102 Homo sapiens
418675 Gallus gallus
379779 Xenopus laevis
19889 Mus musculus
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