Ring Finger Protein 213 Proteins (RNF213)

RNF213 encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. Additionally we are shipping RNF213 Antibodies (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNF213 57674 Q63HN8
Rat RNF213 RNF213 303735  
Mouse RNF213 RNF213 672511  
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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RNF213 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Ring Finger Protein 213 (RNF213) Interaction Partners

Human Ring Finger Protein 213 (RNF213) interaction partners

  1. These results suggest that, in our cohort of Korean patients, the p.Arg4810Lys is the only variant that is strongly associated with Moyamoya disease among the 30 RNF213 variants listed in the Human Gene Mutation Database.

  2. This study suggests that the rs112735431 polymorphism of the RNF213 may be linked to the hypertension in moyamoya disease.

  3. PTP1B (show PTPN1 Proteins)/RNF213/alpha-KGDD pathway is critical for survival of HER2 (show ERBB2 Proteins)(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment

  4. Both RNF213 D4013N and V4146A significantly decreased re-endothelialization in the migration assay compared with RNF213 WT and the control vector.

  5. We found that RNF213 single nucleotide polymorphism rs6565666 was associated with intracranial aneurysms in French-Canadian individuals.

  6. The RNF213 p.R4810K variant appears to be significantly associated with coronary artery disease in the Japanese population.

  7. RNF213 p.R4810K polymorphism was significantly associated with quasi-moyamoya disease.

  8. RNF213 is not only associated with MMD but also associated with intracranial major artery stenosis. The genotypes of RNF213 correlate with the phenotypes of MMD.

  9. Case-control study and meta-analysis both provide evidence of an association between the rs112735431 polymorphism in the RNF213 gene and moyamoya risk.

  10. This is the first report, to our knowledge, of different moyamoya disease phenotypes in a familial case involving the same heterozygous c.14429G > A variant in RNF213.

Mouse (Murine) Ring Finger Protein 213 (RNF213) interaction partners

  1. PTP1B (show PTPN1 Proteins)/RNF213/alpha-KGDD pathway is critical for survival of HER2 (show ERBB2 Proteins)(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment

  2. The mechanisms underlying the development of moyamoya disease currently remain unclear, the RNF213 abnormality may compromise immunological self-tolerance, thereby contributing to the development of moyamoya disease.

  3. The Rnf213 gene was up-regulated in the ischemic brain, especially at the penumbra (show TSPAN33 Proteins) area, as early as 6 h after transient middle cerebral artery occlusion

  4. Suggest that RNF213 R4810K carriers have lower angiogenic capacities, indicating that they might be more susceptible to insults of cerebral hypoxia.

  5. Angiogenesis was enhanced in mice lacking RNF213 after chronic hind-limb ischemia, which suggested the potential role of the RNF213 abnormality in the development of pathological vascular networks in chronic ischemia.

  6. Functional loss of RNF213 did not sufficiently induce moyamoya disese. Suppression of vascular remodeling in RNF213-/- requires further examination to clarify the role of RNF213.

  7. These findings indicated that the disruption of Rnf213 improved glucose tolerance by protecting islet beta cells.

RNF213 Protein Profile

Protein Summary

This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2\;17)(p23\;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8\;17)(q24\;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RNF213

  • ring finger protein 213 (RNF213)
  • ring finger protein 213 (Rnf213)
  • 6030403J01 protein
  • ALO17 protein
  • C17orf27 protein
  • D11Ertd759e protein
  • KIAA1618 protein
  • mKIAA1554 protein
  • MYMY2 protein
  • MYSTR protein
  • NET57 protein
  • RGD1308168 protein
  • RNF213 protein

Protein level used designations for RNF213

ring finger protein 213 , protein ALO17-like , ALK lymphoma oligomerization partner on chromosome 17 , E3 ubiquitin-protein ligase RNF213 , mysterin , protein ALO17

GENE ID SPECIES
509283 Bos taurus
100626814 Sus scrofa
422080 Gallus gallus
100461067 Pongo abelii
100636041 Amphimedon queenslandica
57674 Homo sapiens
303735 Rattus norvegicus
672511 Mus musculus
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