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SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010].. Additionally we are shipping Scinderin Antibodies (18) and Scinderin Kits (5) and many more products for this protein.
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High levels of SCIN expression in gastric cancer tissue correlate with poor prognosis of patients. SCIN enhances the invasion and metastasis of GC cells through activating the Cdc42 (show CDC42 Proteins) pathway to increase the formation of filopodia.
Suppression of scinderin impairs proliferation and migration of gastric cancer SGC7901 cells and attenuates its epithelialmesenchymal transition process.
SCIN plays an important role in lung carcinoma cell proliferation
These results suggest that SCIN plays an important role in the proliferation of prostate cancer cells and lentivirus-mediated inhibition of SCIN expression may be a potential therapeutic method for the treatment of prostate cancer
Scinderin expression does not correlate with prognosis in head and neck cancer.
calcium binding to the N terminus of adseverin dominates the activation process to expose the F-actin binding site on A2
Adseverin knockdown also suppressed the RANKL (show TNFSF11 Proteins)-mediated induction of nuclear factor of activated T-cell (show NFATC3 Proteins) c1 (NFATc1 (show NFATC1 Proteins)), which is a key transcription factor in osteoclastogenesis.
Data indicate that adseverin (Ads) regulates actin cytoskeleton in osteoclasts.
Ads (show AGPS Proteins) is a RANKL (show TNFSF11 Proteins) induced early regulator of osteoclastogenesis with a potential role in pre-osteoclast differentiation and fusion.
adseverin induction is a specific gene regulatory effect by TCDD on thymocytes.
Overexpression of Scin is associated with asthma.
SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001
, gelsolin-like protein