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catalyzes the conversion of L-serine to D-serine [RGD, Feb 2006].. Additionally we are shipping Serine Racemase Antibodies (57) and Serine Racemase Kits (4) and many more products for this protein.
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Data suggest that Ser (show SIGLEC1 Proteins)-84 and Arg-135 are important in catalysis and substrate specificity of SRR.
Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form
MiR (show MLXIP Proteins)-193a-3p and miR (show MLXIP Proteins)-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B (show RAB27B Proteins) and SRR genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma
Loss-of-function mutation of the gene encoding serine racemase significantly attenuates excitotoxicity in retina.
Serine racemase activity and dynamics are regulated by halides, ATP and malonate.
In serine racemase, similarly to the related enzyme alanine racemase, the unprotonated pyridoxal-5'-phosphate -substrate intermediate is stabilized mostly due to solvation effects contributed by water molecules and active-site residues.
FBXO22 (show FBXO22 Proteins) protein is required for optimal synthesis of NMDA receptor coagonist D-serine by interacting with serine racemase, activating it, and preventing its targeting to membranes.
S84A serine racemase mutant behaved like serine dehydratase (show SDS Proteins), whereas A65S serine dehydratase (show SDS Proteins) mutant acquired an additional function of using D-serine as a substrate.
Six SNP(rs7754840 in CDKAL1 (show CDKAL1 Proteins), rs391300 in SRR, rs2383208 in CDKN2A/2B, rs4402960 in IGF2BP2 (show IGF2BP2 Proteins), rs10830963 in MTNR1B, rs4607517 in GCK (show GCK Proteins))risk alleles of type 2 diabetes were associated with GDM in pregnant Chinese women.
Serine racemase and D-serine are involved in both pre-symptomatic and progressive phases of amyotrophic lateral sclerosis, demonstrating a link between mutant superoxide dismutase (SOD)1 (show SOD1 Proteins) and a glial-derived toxic mediator in transgenic mice.
results indicate that SRR indeed acts as a d-Asp (show C3 Proteins) biosynthetic enzyme in some organs and/or tissues, and also provide evidences that there should be some additional enzyme for d-Asp (show C3 Proteins) synthesis in mammals.
data show neuronal serine racemase could regulate the extracellular D-serine signaling responsible for N-methyl-D-aspartate type glutamate (show GRIN1 Proteins) receptor activation in the hippocampus
The retinal levels of d-serine are tightly controlled during the first week of postnatal life and vary according to deficiencies in Serine racemase.
In the neocortex and hippocampus only 24-40% of interneurons expressed serine racemase.
SR interacts with the synaptic proteins, postsynaptic density protein 95 (PSD-95 (show DLG4 Proteins)) and stargazin, forming a ternary complex.
The findings of this study suggest that D-serine-dependent NMDAR (show GRIN1 Proteins) activity is involved in mediating the cellular and behavioral effects of 5-HT2AR activation.
serine racemase in the skin epidermis is involved in the differentiation of epidermal keratinocytes and the formation of the skin barrier
Disruption of D-serine synthesis, by blocking SRR, during developmental stages leads to behavioral abnormalities relevant to prodromal symptoms and schizophrenia.
SRR and/or d-serine may be involved in the production of d-aspartic acid in mouse forebrains
The serine racemase-null mutant mouse has less than 10% of normal brain D-serine in a model of schizophrenia
catalyzes the conversion of L-serine to D-serine
, Serine racemase
, D-serine ammonia-lyase
, D-serine dehydratase
, L-serine ammonia-lyase
, L-serine dehydratase