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The protein encoded by NEU1 is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Additionally we are shipping NEU1 Antibodies (56) and NEU1 Proteins (13) and many more products for this protein.
Neu1 inhibits lipolysis induced by beta-adrenergic stimulation in adipocytes via interactions with Plin1 (show PLIN1 ELISA Kits) on lipid drops.
Neu1 is the only lysosomal multienzyme complex gene underexpressed in mucopolysaccharidosis type I mice.
Neu1 desialylation is a mechanism of Fc-independent platelet clearance in immune thrombocytopenia.
Data indicate a role for neuraminidase 1 (Neu1) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 ELISA Kits)) interaction and endotoxemia.
elastin (show ELN ELISA Kits)-derived peptides as an enhancer of atherogenesis and defines the Neuraminidase 1/PI3Kgamma (show PIK3CG ELISA Kits) signalling pathway as a key mediator
significant increases in Col1a1 (show COL1A1 ELISA Kits), serine/threonine-protein kinase 1, Ctnnb1 (show CTNNB1 ELISA Kits), CSRNP1, Ddit4 (show DDIT4 ELISA Kits), Cyp2e1 (show CYP2E1 ELISA Kits), and Krit1 (show KRIT1 ELISA Kits) expressions and great decreases inreceptor D2, Neu1, and Dhcr7 (show DHCR7 ELISA Kits) expressions following long-term exposure to TiO2 NPs (show NPS ELISA Kits)
NEU1 deficiency has a role in determining amyloid precursor protein (show APP ELISA Kits) levels and amyloid-beta secretion via deregulated lysosomal exocytosis
Neu1 sialidase and matrix metalloproteinase-9 (show MMP9 ELISA Kits) cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 (show TLR7 ELISA Kits) and -9 activation, cellular signaling and pro-inflammatory responses.
The activity of NEU1 was preferentially higher in epididymal fat and lower in the livers of two strains of obese and diabetic mice.
these studies identify Neu1 as a novel component of the signaling pathways of energy metabolism and glucose uptake.
Data suggest that mutations c.90delC (p.Tyr30Ter) and c.572A>T (p.Asp191Val) of the NFU1 (show NFU1 ELISA Kits) gene probably underlie the pathogenesis of multiple mitochondrial dysfunction syndrome (MMDS).
Elevated NEU1 expression alters functional activities of distinct lung cell types in vitro and recapitulates lymphocytic infiltration and collagen accumulation in vivo, consistent with mechanisms implicated in lung fibrosis.
initial treatment with an EGFR (show EGFR ELISA Kits)-TKI is a reasonable option for patients presenting with EGFR (show EGFR ELISA Kits) mutation-positive NSCLC and a CM.
miR (show MLXIP ELISA Kits)-125b functions as an oncogene (show RAB1A ELISA Kits) in gastric cancer and represents a new potential therapeutic target for gastric cancer.
NEU1 siRNA can effectively inhibit proliferation, apoptosis, and invasion of human ovarian cancer cells by targeting lysosome and oxidative phosphorylation signaling, which can serve as a new target ovarian cancer treatment
How the point mutations of the neuraminidase (show NEU ELISA Kits) sequences affected the susceptibility of H9N2 virus to oseltamivir is still to be determined and deserve further investigations
Basal Neu-1 catalytic activity is strongly increased in aged cells.
Flagellin (show FliC ELISA Kits) drives NEU1 to desialylate MUC1 (show MUC1 ELISA Kits), thereby increasing its adhesiveness for Pseudomonas aeruginosa and its shedding
Muc1 (show MUC1 ELISA Kits) clearly plays a significant role in enhancing the hypoxia-inducible transcription factors protective pathway during ischemic insult and recovery in kidney epithelia
NEU1 gene is not responsible for the lysosomal storage disease of Japanese Black cattle.
The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.
sialidase 1 (lysosomal sialidase)
, Isotocin-neurophysin IT 1
, neuraminidase 1
, G9 sialidase
, HLA-B-associated transcript 7
, N-acetyl-alpha-neuraminidase 1
, lysosomal sialidase
, sialidase 1
, acetylneuraminyl hydrolase