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Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. Additionally we are shipping Synaptopodin Antibodies (97) and Synaptopodin Kits (29) and many more products for this protein.
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SYNPO variants are involved in AMPA (show GRIA3 Proteins) receptor trafficking and neuronal plasticity, which are associated with cognitive impairment and schizophrenia susceptibility.
This study identified and confirmed SYNPO protein changes within the postsynaptic density in schizophrenia
Case Report: immunohistologically detected synaptopodin upregulation in foamy podocytes in Fabry disease due to novel alpha-galactosidase A (show GLA Proteins) mutation.
expression significantly down-regulated in presence of WT1 (show WT1 Proteins) R458Q mutation
Shear stress induced actin binding proteins including SYNPO may play a critical role in endothelial wound healing.
These results suggested that the SA is an important component of the molecular machinery controlling the calcium-dependent accumulation of AMPA (show GRIA3 Proteins)-receptors (AMPA (show GRIA3 Proteins)-R) at excitatory synapses. [review]
The urinary mRNA profiles of synaptopodin, podocalyxin, CD2-AP, alpha-actin4, and podocin were found to increase with the progression of diabetic nephropathy.
Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments.
Heterozygous mutations in the promoters of the ACTN4 (show ACTN4 Proteins) and SYNPO genes are found in patients with idiopathic focal segmental glomerulosclerosis.
interaction with tight junction protein (show OCLN Proteins) MAGI-1 (show MAGI1 Proteins)
miR-206 was up-regulated in Adriamycin nephropathy mice, which led to severe podocyte injury and inhibited the expression of WT1 and synaptopodin. In vitro, over expression of miR-206 induced WT1 and synaptopodin degradation and actin rearrangement, initiating a catastrophic collapse of the entire podocyte-stabilizing system.
WAVE1 (show WASF1 Proteins) phosphorylation in podocytes. Synaptopodin is a well-characterized target of CsA (show HSPA9 Proteins). WAVE1 (show WASF1 Proteins) overexpression and synaptopodin knockdown experiments directly demonstrated that WAVE1 (show WASF1 Proteins) expression is not dependent on synaptopodin expression, and vice versa
Inhibition of STAT3 (show STAT3 Proteins) signaling in podocytes reduced synaptopodin levels in these cells.
synaptopodin has an essential, calcium store-related role in regulating synaptic plasticity in cultured hippocampal neurons
Our results identify synaptopodin as a substrate of PKA in hippocampal neurons and point to an essential role for synaptopodin in activity-dependent regulation of dendritic spine dynamics and synaptic plasticity in postnatal brain development.
Synaptopodin has an important role in homeostatic synaptic plasticity
Together, these results indicate that alpha-actinin (show ACTN1 Proteins) and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS (show AR Proteins).
Synpatopodin may play an important role in the changes of PSD-95 and NR1 protein levels and other synaptic alterations that are induced by corticosterone
HGF (show HGF Proteins) protects podocytes from a loss of nephrin (show NPHS1 Proteins), at least in part, through maintaining synaptopodin in nephritic mice with albuminuria.
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997