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Syndecan 4 Proteins (SDC4)

The protein encoded by SDC4 is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. Additionally we are shipping Syndecan 4 Antibodies (135) and Syndecan 4 Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SDC4 6385 P31431
SDC4 20971 O35988
SDC4 24771 P34901
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Top Syndecan 4 Proteins at

Showing 10 out of 34 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Human Human Fc Tag Binding of human Syndecan4-Fc to human FGF-b in a functional ELISA assay. 1μg/ml of hFGF-b or BSA (control) was coated on a microplate. Human Syndecan4-Fc  or control Fc proteins were incubated at various concentrations, and followed by incubation of anti-human IgG(Fc specific) HRP conjugates. The level of the specific interaction was measured with a colorimetric method using TMB substrate solution. 50 μg Log in to see 5 to 8 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
HOST_Mammalian Cells Mouse His tag   50 μg Log in to see 5 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

SDC4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , , ,
Mouse (Murine) , , , ,
, ,
Rat (Rattus) ,

Top referenced Syndecan 4 Proteins

  1. Human SDC4 Protein expressed in Escherichia coli (E. coli) - ABIN668053 : Woods, Couchman: Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component. in Molecular biology of the cell 1994 (PubMed)
    Show all 2 references for ABIN668053

  2. Mouse (Murine) SDC4 Protein expressed in Human Cells - ABIN2008245 : Bass, Humphries: Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. in The Biochemical journal 2002 (PubMed)

More Proteins for Syndecan 4 (SDC4) Interaction Partners

Zebrafish Syndecan 4 (SDC4) interaction partners

  1. We show here that sdc2 (show SDC2 Proteins),sdc3 (show SDC3 Proteins) and sdc4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.

  2. cell adhesion properties of syndecan-4 are consistent across the vertebrate spectrum and reflect an early acquisition of specialization after syndecan (show SDC1 Proteins) gene duplication events at the invertebrate/early chordate boundary

Turkey Syndecan 4 (SDC4) interaction partners

  1. Dynamic changes in syndecan-4- and glypican-1 (show GPC1 Proteins)-positive satellite cells indicate that they are differentially expressed during myogenesis.

  2. The cytoplasmic domain of syndecan-4 is required for cell migration and RhoA (show RHOA Proteins) activation in skeletal muscle satellite cells.

  3. results suggest that syndecan-4 and its side chains play important roles in regulating FAK (show PTK2 Proteins) activity, and PKCalpha (show PKCa Proteins) and beta1-integrin cell membrane localization, but not cell apoptosis and vinculin (show VCL Proteins)-containing focal adhesion formation in satellite cells

  4. These data suggested that expression of the myogenic regulatory transcription factors are dependent upon expression of glypican-1 (show GPC1 Proteins) and syndecan-4 during satellite cell proliferation and differentiation, and Pax7 (show PAX7 Proteins) expression is influenced by glypican-1 (show GPC1 Proteins).

  5. syndecan-1 (show SDC1 Proteins), syndecan-4, or glypican-1 (show GPC1 Proteins) differentially affect the processes of turkey muscle cell proliferation and differentiation, and can regulate these developmental stages in an FGF2 (show FGF2 Proteins)-independent manner

Human Syndecan 4 (SDC4) interaction partners

  1. results suggest that SDC4 alleles affect lipid profile in elderly subjects and may in part mediate the link between LDL-C and longevity.

  2. Synd4 shedding is a molecular pathological alteration in the development and maintenance of inflammation-associated atrial fibrillation.

  3. Syndecan-4 is essential for transmitting the mechanotransduction signals via activation of PKC-alpha and is important for tumor cells spreading, assembly of actin cytoskeleton and cell contractility.

  4. demonstrate that HER2 (show ERBB2 Proteins) is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1 (show SDC1 Proteins), and EGFR (show EGFR Proteins) is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4

  5. Dynamic catch of a Thy-1 (show THY1 Proteins)-integrin alpha5beta1+syndecan-4 trimolecular complex explains extraordinary cancer cell adhesion to the vascular endothelium.

  6. Syndecan-4 polymorphisms were associated with essential hypertension, body mass index, and coronary artery disease prevalence in the Tampere adult population cardiovascular risk study.

  7. No association was found with SDC4 and breast cancer.

  8. Data indicate that depletion of syndecan 4 (S4) in umbilical vein endothelial cells (HUVECs) using shRNA inhibited flow-induced alignment in vitro, which was rescued by re-expression of S4.

  9. define a role for TG2 (show TGM2 Proteins) activity at the surface of human macrophages in multiple stages of AC clearance and we propose that TG2 (show TGM2 Proteins), in association with heparan sulphates may exert its effect on AC clearance via a mechanism involving the crosslinking of CD44 (show CD44 Proteins)

  10. syndecan 4 is the predominant heparan sulfate proteoglycan in the glomerular endothelial cells glycocalyx

Mouse (Murine) Syndecan 4 (SDC4) interaction partners

  1. Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2 (show NFE2L2 Proteins)-mediated control of SLPI (show SLPI Proteins) and syndecan 4.

  2. Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice.

  3. SDC4 plays an important role in asthma induction. Disturbed SDC4 signalling leads to an impaired motility and directional migration of antigen-presenting dendritic cells.

  4. Syndecan-4 exerts a dual role in collagen cross-linking, one involving its cytosolic domain and calcineurin (show PPP3CA Proteins)/nuclear factor of activated T-cells signalling leading to collagen

  5. Locally generated Sdc4 may play a role in regulating TRPC6 (show TRPC6 Proteins) channels, and may contribute to glomerular pathology.

  6. Sdc4 contributes to the development of collagen induced arthritis by promoting germinal center formation and autoantibody production through its regulation of SDF-1 (show CXCL12 Proteins)-mediated B cell migration.

  7. binding interaction between syndesmos (show NUDT16L1 Proteins) and syn4 (show STX4 Proteins)(cyto) was characterized as a low-affinity interaction (Kd = 62 muM) by surface plasmon resonance and nuclear magnetic resonance

  8. the crucial role of SDC-4 for neuron density, neurite length, and branches.

  9. SDC4 participates in amelogenesis, and FGF10 (show FGF10 Proteins) may modulate dental epithelial cell behaviors through the regulation of SDC4 expression.

  10. Data show that endothelial cells (ECs) from the thoracic aortas of syndecan 4 (S4-/-) mice were poorly aligned in the direction of the flow.

Rabbit Syndecan 4 (SDC4) interaction partners

  1. Findings suggest that syndecan-4 may be involved in acquisition of resistance to detachment-induced cell death (anoikis resistance) in endothelial cells, thus contributing to cell transformation.

Syndecan 4 (SDC4) Protein Profile

Protein Summary

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22.

Gene names and symbols associated with Syndecan 4 Proteins (SDC4)

  • syndecan 4 (SDC4)
  • syndecan 4 (sdc4)
  • syndecan 4 (Sdc4)
  • syndecan-4-like (LOC100352455)
  • AA959608 protein
  • amphiglycan protein
  • AW108331 protein
  • RATRYUDOCA protein
  • RYUDOCA protein
  • ryudocan protein
  • SDC4 protein
  • sdc4l protein
  • syn-4 protein
  • syn4 protein
  • Synd4 protein
  • syndecan-4 protein
  • wu:fc47g09 protein

Protein level used designations for Syndecan 4 Proteins (SDC4)

syndecan 4 , ryudocan core protein , syn4 , syndecan 4 like , syndecan-4 , heparan sulfate proteoglycan , syndecan 4 (amphiglycan, ryudocan) , amphiglycan , ryudocan amphiglycan , syndecan proteoglycan 4 , Ryudocan/syndecan 4 , SYND4

469953 Pan troglodytes
568593 Danio rerio
710914 Macaca mulatta
100126249 Meleagris gallopavo
100137516 Papio anubis
100144973 Xenopus (Silurana) tropicalis
419184 Gallus gallus
6385 Homo sapiens
20971 Mus musculus
24771 Rattus norvegicus
397528 Sus scrofa
100723253 Cavia porcellus
485893 Canis lupus familiaris
508133 Bos taurus
101108677 Ovis aries
100174444 Pongo abelii
100352455 Oryctolagus cuniculus
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