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Synovial Apoptosis Inhibitor 1, Synoviolin Proteins (SYVN1)

SYVN1 encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. Additionally we are shipping Synovial Apoptosis Inhibitor 1, Synoviolin Antibodies (103) and Synovial Apoptosis Inhibitor 1, Synoviolin Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SYVN1 84447 Q86TM6
SYVN1 74126 Q9DBY1
Rat SYVN1 SYVN1 361712  
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Top Synovial Apoptosis Inhibitor 1, Synoviolin Proteins at

Showing 4 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

SYVN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) Interaction Partners

Human Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) interaction partners

  1. Study shows that mir125b is up-regulated in osteoarthritis (OA) and inversely correlated with SYNV1 expression. Also, findings demonstrated that miR (show MLXIP Proteins)- 125b-5p could promote apoptosis of synovial cells through targeting the SYVN1 gene, and the excessive apoptosis of synovial cells could contribute to the development of OA.

  2. HRD1 is a novel substrate for USP19. USP19 negatively regulates the ubiquitination of HRD1 and prevents it from undergoing proteasomal degradation.

  3. Prion protein (show PRNP Proteins) mutants inhibit Hrd1-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP (show GDF10 Proteins).

  4. OS-9 (show OS9 Proteins), an ER-resident lectin, acts downstream of Grp94 (show HSP90B1 Proteins) to further recognize misfolded alpha1 subunits in a glycan-dependent manner. This delivers misfolded alpha1 subunits to the Hrd1-mediated ubiquitination and the valosin-containing protein (show vcp Proteins)-mediated extraction pathway.

  5. These findings uncover a novel role for HRD1 in breast cancer.

  6. The inherently unstable nature of the human SEL1L (show SEL1L Proteins) protein lies in its transmembrane domain, and that association of HRD1 with the SEL1L (show SEL1L Proteins) transmembrane domain restored its stability.

  7. specific silencing of Derlin-2 (show DERL2 Proteins), p97 (show EIF4G2 Proteins) and HRD1 by shRNAs increases steady state levels of proinsulin (show INS Proteins). these ERAD constituents are critically involved in proinsulin (show INS Proteins) degradation and may therefore also play a role in subsequent antigen generation.

  8. Charcot-Marie-Tooth disease-related PMP22 (show PMP22 Proteins) is trapped in the endoplasmic reticulum by calnexin (show CANX Proteins)-dependent retention and Rer1 (show RER1 Proteins)-mediated early Golgi retrieval systems and partly degraded by the Hrd1-mediated endoplasmic reticulum-associated degradation system.

  9. Results show that HRD1 and RFP2 (show TRIM13 Proteins) contributes are required for the disposal of V247M alpha-sarcoglycan (show SGCA Proteins) mutant.

  10. Herp localizes to the endoplasmic reticulum-derived quality control compartment (ERQC) and recruits HRD1, which targets to endoplasmic reticulum associated degradation the substrate presented by the OS-9 lectin at the ERQC.

Mouse (Murine) Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) interaction partners

  1. SYVN1 may play an important role in inhibiting ER stress, chronic inflammation, and vascular overgrowth associated with DR.

  2. Data show that inositol requiring enzyme 1alpha (IRE1alpha (show ERN1 Proteins)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L (show SEL1L Proteins) proten-Hrd1 protein endoplasmic reticulum (ER)-associated degradation (ERAD) complex.

  3. Hrd1 is an essential component of the adaptive endoplasmic reticulum stress response in cardiac myocytes.

  4. The results highlight a novel function for SYVN1 in the control of body weight and mitochondrial biogenesis through negative regulation of PGC (show PGC Proteins)-1b.

  5. Data indicate that E3 ubiquitin-protein ligase (show UBE2K Proteins) Hrd1 catalyzed ubiquitination and degradation of the transcriptional suppressor B lymphocyte-induced maturation protein 1 (BLIMP1 (show PRDM1 Proteins)) to promote MHC-II antigen expression.

  6. oxidative stress-induced (show SQSTM1 Proteins) HRD1 insolubilization might be involved in a vicious cycle of increased amyloid beta production and amyloid beta-induced oxidative stress in Alzheimer's disease pathogenesis.

  7. results indicate that Hrd1 plays an important role in the maturation of collagen I in renal fibrosis, and that Sec23A (show SEC23A Proteins) pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis

  8. Synoviolin up-regulates amyloid beta production by targeting a negative regulator of gamma-secretase, Rer1 (show RER1 Proteins), for degradation.

  9. HRD1 is colocated with the neural stem cell marker protein nestin (show NES Proteins) and glial fibrillary acidic protein (show GFAP Proteins) in the endoplasmic reticulum membrane of the NSCs of the subventricular zone (SVZ astrocytes) but in the cell nucleus of in the dentate gyrus

  10. these results clearly suggest that both beta-TrCP (show BTRC Proteins)- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (show NRF1 Proteins) to maintain cellular homeostasis.

Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) Protein Profile

Protein Summary

This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.

Gene names and symbols associated with SYVN1

  • synovial apoptosis inhibitor 1, synoviolin (syvn1)
  • synovial apoptosis inhibitor 1, synoviolin (SYVN1)
  • synovial apoptosis inhibitor 1, synoviolin (Syvn1)
  • 1200010C09Rik protein
  • AW211966 protein
  • C85322 protein
  • D530017H19Rik protein
  • DER3 protein
  • Hrd1 protein
  • RGD1310488 protein

Protein level used designations for SYVN1

E3 ubiquitin-protein ligase synoviolin , synovial apoptosis inhibitor 1, synoviolin , HMG-coA reductase degradation 1 homolog , synoviolin 1 , HRD1 protein

100327246 Xenopus (Silurana) tropicalis
100514334 Sus scrofa
100581754 Nomascus leucogenys
84447 Homo sapiens
483746 Canis lupus familiaris
508358 Bos taurus
74126 Mus musculus
361712 Rattus norvegicus
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