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Syntaxin Binding Protein 1 Proteins (STXBP1)

STXBP1 encodes a syntaxin-binding protein. Additionally we are shipping Syntaxin Binding Protein 1 Antibodies (118) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STXBP1 25558 P61765
STXBP1 6812 P61764
STXBP1 20910 O08599
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Top Syntaxin Binding Protein 1 Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Log in to see 20 to 21 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

STXBP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , , ,
, , ,
Mouse (Murine)

Top referenced Syntaxin Binding Protein 1 Proteins

  1. Human STXBP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004754 : Swanson, Steel, Valle: Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release. in Genomics 1998 (PubMed)
    Show all 4 references for ABIN2004754

More Proteins for Syntaxin Binding Protein 1 (STXBP1) Interaction Partners

Human Syntaxin Binding Protein 1 (STXBP1) interaction partners

  1. We report the case of a 19-month-old child with Ohtahara syndrome who displays a previously unreported mutation in STXBP1 This mutation is located in a donor splice site and eliminates exon 14, resulting in a truncated protein

  2. We conducted a cohort study to analyze STXBP1 in 42 patients with epileptic encephalopathy. We identified four novel mutations: two splicing mutations, a frameshift mutation, and a nonsense mutation.

  3. Reduced expression of STXBP1 leads to changes in the expression and localization of syntaxin-1 (show STX1A Proteins) in pluripotent stem cells from epileptic encephalopathy patient.

  4. Seizure severity and intellectual disability were connected to STXBP1 encephalopathy patients.

  5. partial STXBP1 loss of function robustly impairs neurotransmitter release in human neurons, and suggest that heterozygous STXBP1 mutations cause early epileptic encephalopathy specifically through a presynaptic impairment.

  6. The case described suggests a relationship between the Rett syndrome and the STXBP1 gene not described so far, making the search for STXBP1 gene mutations advisable in patients with Rett syndrome and early onset of epilepsy.

  7. A de novo mutation in STXBP1 was detected with exome sequencing together with profound impairment of complex I of the mitochondrial respiratory chain on muscle biopsy. Findings implicate a secondary impairment of mitochondrial function.

  8. Epileptic encephalopathy related to mutations in the STXBP1 genes.

  9. In vitro interaction assays indicated that Doc2b (show DOC2B Proteins) is required to bridge the interaction between Munc18c (show STXBP3 Proteins) and Munc18-1 in the macromolecular complex; Munc18c (show STXBP3 Proteins) and Munc18-1 failed to associate in the absence of Doc2b (show DOC2B Proteins)

  10. STXBP1 gene mutation was found in 1 out of 11 patients

Mouse (Murine) Syntaxin Binding Protein 1 (STXBP1) interaction partners

  1. In this studying the Munc18-1-/- nervous system, we demonstrate that synaptic activity is dispensable for the early formation of spinal motor circuits at the levels of axon guidance, differentiation of transcriptional identity, and mRNA expression.

  2. Vamp2 (show VAMP2 Proteins) mutations that impair Munc18-1 binding inhibit spontaneous as well as evoked neurotransmitter release, providing evidence for the Vamp2 (show VAMP2 Proteins)-regulating function of Munc18-1 in synaptic exocytosis.

  3. A dynamic PKC phosphorylation/de-phosphorylation cycle of Munc18-1 drives short-term enhancement of transmitter release during post-tetanic potentiation.

  4. miR-218 and miR-322 directly interact with Stxbp1 by targeting the 3'UTR of its mRNA.

  5. Munc18-1 levels correlate with synaptic strength.

  6. Syntaxin binding protein 1 is not required for allergic inflammation via IgE-mediated mast cell activation.

  7. [review] Regulation of cortical F-actin is a shared function of Sec1/Munc18-like proteins; a way to gain more insight in the molecular mechanism underlying the Munc18-1-mediated cortical F-actin regulation is proposed.

  8. The N-terminal syntaxin-1 (show STX1A Proteins) domains mediate different functions in synaptic vesicle fusion, probably via formation of distinct Munc18/SNARE (show VTI1B Proteins)-protein complexes.

  9. SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1 (show SYT1 Proteins).

  10. a novel indirect role for Munc18-1 in facilitating syntaxin 4 (show STX4 Proteins)-mediated granule pre-docking to support first-phase insulin (show INS Proteins) exocytosis.

Zebrafish Syntaxin Binding Protein 1 (STXBP1) interaction partners

  1. Epilepsy, Behavioral Abnormalities, and Physiological Comorbidities in Syntaxin-Binding Protein 1 (STXBP1) Mutant Zebrafish.

Syntaxin Binding Protein 1 (STXBP1) Protein Profile

Protein Summary

This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with STXBP1

  • syntaxin binding protein 1 (stxbp1)
  • syntaxin binding protein 1 (Tb09.160.0780)
  • syntaxin binding protein 1 (STXBP1)
  • syntaxin binding protein 1 (Stxbp1)
  • syntaxin binding protein 1a (stxbp1a)
  • AI317162 protein
  • AI326233 protein
  • ANC18HA protein
  • fj43h10 protein
  • hunc18 protein
  • MGC88906 protein
  • MGC146482 protein
  • MMS10-G protein
  • Ms10g protein
  • Munc-18a protein
  • MUNC18-1 protein
  • N-sec1 protein
  • nsec1 protein
  • NSEC1A protein
  • P67 protein
  • Rb-sec1 protein
  • RBSEC1 protein
  • rbSec1A protein
  • rbSec1B protein
  • rop protein
  • Sec1 protein
  • stxbp1 protein
  • Sxtbp1 protein
  • UNC18 protein
  • Unc18-1 protein
  • UNC18A protein
  • Unc18h protein
  • wu:fj36d12 protein
  • wu:fj43h10 protein
  • zgc:114171 protein

Protein level used designations for STXBP1

syntaxin binding protein 1 , Ras opposite , syntaxin-binding protein 1-like , p67 , protein unc-18 homolog 1 , protein unc-18 homolog A , syntaxin-binding protein 1 , unc-18 homolog , unc-18-1 , unc-18A , N-Sec1 , neuronal SEC1 , unc18-1 , UNC-18 homolog , minisatellite 10g detected by probe MMS10 , syntaxin 1-binding protein

448217 Xenopus (Silurana) tropicalis
779976 Xenopus (Silurana) tropicalis
3660246 Trypanosoma brucei TREU927
100397821 Callithrix jacchus
25558 Rattus norvegicus
6812 Homo sapiens
20910 Mus musculus
404293 Gallus gallus
282378 Bos taurus
100101272 Xenopus laevis
100173563 Pongo abelii
574003 Danio rerio
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