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Syntaxin Binding Protein 2 Proteins (STXBP2)

STXBP2 encodes a member of the STXBP/unc-18/SEC1 family. Additionally we are shipping STXBP2 Antibodies (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STXBP2 6813 Q15833
STXBP2 20911 Q64324
STXBP2 81804 Q62753
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Top STXBP2 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

STXBP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Syntaxin Binding Protein 2 (STXBP2) Interaction Partners

Human Syntaxin Binding Protein 2 (STXBP2) interaction partners

  1. red blood cells express Munc18-2 and that erythroid cells from patients with FHL-5 exhibit intrinsic defects caused by STXBP2/Munc18-2 mutations.

  2. Munc18-2(R65Q) and Munc18-2(R65W) retain the ability to interact with and stabilize STX11 (show STX11 Proteins). However, presence of Munc18-2(R65Q/W) in patient-derived lymphocytes and forced expression in control CTLs and NK cells diminishes degranulation and cytotoxicity.

  3. Data show that all but one patient with atypical familial hemophagocytic lymphohistiocytosis carried at least one splice-site mutation in UNC13D (show UNC13D Proteins) or STXBP2.

  4. Munc18-2 binds the N-terminal peptide of Stx11 (show STX11 Proteins) with a ~20-fold higher affinity than Stx3 (show STX3 Proteins), suggesting a potential role in selective binding.

  5. We report that FHL-5 neutrophils have a profound defect in granule mobilization, resulting in inadequate bacterial killing, in particular, of gram-negative Escherichia coli, but not of Staphylococcus aureus.

  6. Mutations in STXBP2 do not only affect cytotoxic T lymphocytes but also cause changes in the intestinal and renal epithelium resulting in severe, osmotic diarrhea and renal proximal tubular dysfunction

  7. Double knockdown of Munc18-1 and Munc18-2 in mast cells eliminates both IgE-dependent and ionomycin-induced degranulation and causes a significant reduction in syntaxin-11 without altering expressions of the other syntaxin isoforms examined.

  8. Novel mutation in STXBP2 prevents IL-2 (show IL2 Proteins)-induced natural killer cell cytotoxicity in familial hemophagocytic lymphohistiocytosis.

  9. We report the largest cohort of patients with FHL5 so far, describe an extended disease spectrum, and demonstrate for the first time a clear genotype-phenotype correlation.

  10. Munc18b is functionally coupled to the assembly of exocytic SNARE (show NAPA Proteins) complexes and increases exocytosis by interacting with the N-peptide and closed-conformation C-terminus of Stx3 (show STX3 Proteins), thereby neutralizing the secretion-inhibitory effect of this SNARE (show NAPA Proteins).

Mouse (Murine) Syntaxin Binding Protein 2 (STXBP2) interaction partners

  1. Munc18b as an essential gene that is a limiting component of the exocytic machinery of epithelial cells and mast cell.

  2. Munc18-1 (show STXBP1 Proteins) and Munc18-2 display distinct subcellular compartmentalization and can coordinate the insulin (show INS Proteins) exocytotic process differently as a consequence of the actual [Ca(2 (show CA2 Proteins)+)](i).

STXBP2 Protein Profile

Protein Summary

This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with STXBP2

  • syntaxin binding protein 2 (stxbp2)
  • syntaxin binding protein 2 (STXBP2)
  • syntaxin binding protein 2 (Stxbp2)
  • C79054 protein
  • FHL5 protein
  • Hunc18b protein
  • MUNC-18-2 protein
  • Munc-18b protein
  • MUNC18-2 protein
  • Munc18b protein
  • muSec1 protein
  • pp10122 protein
  • Sxtbp2 protein
  • Sxtp2 protein
  • Unc18-2 protein
  • Unc18b protein
  • zgc:85807 protein

Protein level used designations for STXBP2

syntaxin-binding protein 2 , protein unc-18 homolog B , unc-18B , munc18-2 , protein unc-18 homolog 2 , syntaxin binding protein Munc18-2 , unc-18 homolog 2 , unc18-2 , Sec1 homolog

406578 Danio rerio
515618 Bos taurus
100171766 Pongo abelii
6813 Homo sapiens
20911 Mus musculus
81804 Rattus norvegicus
403880 Canis lupus familiaris
100525152 Sus scrofa
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