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T-Box 4 Proteins (TBX4)

TBX4 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Additionally we are shipping TBX4 Antibodies (38) and TBX4 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TBX4 9496 P57082
TBX4 21387 P70325
Rat TBX4 TBX4 303399  
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Top TBX4 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 11 to 13 Days

TBX4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for T-Box 4 (TBX4) Interaction Partners

Human T-Box 4 (TBX4) interaction partners

  1. In a cohort with idiopathic or hereditary pulmonary arterial hypertension, a possibly associated mutation was found in 11.10% of the idiopathic cases (n = 16) and in 68.18% of the hereditary cases. There were 4 mutations found in TBX4.

  2. a low level of TBX4 expression suggests a worse prognosis for patients with stage II PDAC. Down-regulation of the TBX4 gene in pancreas is less likely to be regulated by DNA methylation (show HELLS Proteins).

  3. Although TBX4 remains the candidate gene for congenital clubfoot involving 17q23.1-q23.2 duplications, the explanation for variable expressivity and penetrance remains unknown.

  4. data indicate that TBX4 mutations are associated with childhood-onset pulmonary arterial hypertension (PAH), but the prevalence of PAH in adult TBX4 mutation carriers is low

  5. Minimal evidence was found for an association between TBX4 and clubfoot and no pathogenic sequence variants were identified in the two known TBX4 hindlimb enhancer elements.

  6. Microdeletion of 17q22q23.2 encompassing TBX2 (show TBX2 Proteins) and TBX4 in a patient with congenital microcephaly, thyroid duct cyst, sensorineural hearing loss, and pulmonary hypertension.

  7. Mutations in the human TBX4 gene cause small patella syndrome

Mouse (Murine) T-Box 4 (TBX4) interaction partners

  1. These data extend our understanding of the role and regulation of Tbx4 and Shox2 (show SHOX2 Proteins) in limb development and limb associated diseases.

  2. Although postnatal deletion of Tbx4 in oocytes does not obviously impair fertility, it is possible that the reduction in primordial germ cells observed in Tbx4 homozygous null mutant embryos could affect long-term fertility in adults.

  3. Candidate gene approach identifies multiple genes and signaling pathways downstream of Tbx4 in the developing allantois

  4. Mice deficient in Tbx4 and Tbx5 (show TBX5 Proteins) show severely reduced lung branching at mid-gestation.

  5. Tbx4 expression and lineage reveal that various distinct appendages, such as the allantois, hindlimb, and external genitalia, all arise from a single mesenchymal expression domain.

  6. It was shown that, firstly, Pitx1 (show PITX1 Proteins) influences hindlimb outgrowth by regulating Tbx4 expression levels and that, subsequently,Pitx1 (show PITX1 Proteins) shapes hindlimb bone and soft tissue morphology independently of Tbx4.

  7. Study find that Tbx4 is the primary effector of HL identity for both skeletal and muscle development.

  8. Tbx4 is reported to play a key role in separation of the respiratory tract and the esophagus.

  9. Deletion of Tbx4 in hindlimbs specifically affects muscle and tendon patterning without disrupting skeletal development, thus suggesting that distinct cues regulate these processes.

  10. Tbx4 is not sufficient to determine limb-specific morphologies but have a roles in initiating limb outgrowth.

TBX4 Protein Profile

Protein Summary

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity.

Gene names and symbols associated with T-Box 4 Proteins (TBX4)

  • T-box 4 (tbx4)
  • T-box 4 (TBX4)
  • T-box 4 (LOC100350522)
  • T-box 4 (Tbx4)
  • 3930401C23 protein
  • SPS protein
  • TBX4 protein
  • zf-tbx4 protein
  • zTbx4 protein

Protein level used designations for T-Box 4 Proteins (TBX4)

T-box gene 4 , T-box transcription factor TBX4 , T-Box protein 4 , T-box 4 , T-box transcription factor TBX4-like , t-box transcription factor TBX4-like , T-box 4 protein , T-box protein 4 , transcription factor Tbx4

30070 Danio rerio
373989 Gallus gallus
508750 Bos taurus
737130 Pan troglodytes
100010048 Monodelphis domestica
100350522 Oryctolagus cuniculus
100411523 Callithrix jacchus
100459174 Pongo abelii
100591386 Nomascus leucogenys
100620126 Sus scrofa
9496 Homo sapiens
403514 Canis lupus familiaris
21387 Mus musculus
303399 Rattus norvegicus
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