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Spindle assembly factor. Additionally we are shipping TPX2 Antibodies (171) and TPX2 Kits (3) and many more products for this protein.
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detection of TPX2 overexpression could serve as a prognostic marker and therapeutic target for gastric cancer
High TPX2 expression is associated with gastric cancer.
This study concludes that the helical region of TPX2 folds upon binding Aurora-A (show AURKA Proteins), and that stabilization of this helix does not compromise Aurora-A (show AURKA Proteins) activation.
MiR (show MLXIP Proteins)-491 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by downregulating the expression of TPX2.
expression of both TPX2 and PD-L1 (show CD274 Proteins) are associated with persistence/recurrence of cervical intraepithelial neoplasia after cervical conization
the levels and distribution of TPX2 are likely to be determinants of when and where kinesin-5 acts in neurons.
TPX2 was a target gene of miR (show MLXIP Proteins)-491.
Propose TPX2 and AURKA (show AURKA Proteins) as novel co-regulators on the MYC (show MYC Proteins) pathway in colorectal neoplasms.
Aurora A (show AURKA Proteins)-dependent TPX2 phosphorylation controls mitotic spindle length through regulating microtubule flux.
These results indicated that TPX2 has an impact on tumor angiogenesis in pancreatic cancer.
Bcl2l10 (show BCL2L10 Proteins), Tpx2 (show DAZL Proteins), and Aurka (show AURKA Proteins) co-localized on the meiotic spindles, and Bcl2l10 (show BCL2L10 Proteins) was present in the same complex with Tpx2 (show DAZL Proteins).
Study demonstrates that the Golgi resident protein GM130 (show GOLGA2 Proteins) activates the spindle assembly factor TPX2 (show DAZL Proteins) to nucleate microtubules around the Golgi and further captures them to couple mitotic membranes to the spindle.
The findings indicated that Tpx2 (show DAZL Proteins) is essential for maintaining genomic stability through its role in spindle regulation.
Tpx2 (show DAZL Proteins) redistributes from the nucleus to the apical process, and promotes nuclear migration during G2-phase by altering microtubule organization.
Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation (By similarity).
TPX2, microtubule-associated, homolog (Xenopus laevis)
, targeting protein for Xklp2-like
, TPX2, microtubule-associated protein homolog
, TPX2, microtubule-associated, homolog
, differentially expressed in cancerous and non-cancerous lung cells 2
, differentially expressed in lung cells
, hepatocellular carcinoma-associated antigen 519
, preferentially expressed in colorectal cancer
, protein fls353
, restricted expression proliferation associated protein 100
, restricted expression proliferation-associated protein 100
, targeting protein for Xklp2